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Comparison of Sector Interim Recommendations or Preferred Options - 23 February 2006
Health Hazards
Acute Toxicity: Oral (mg/kg)
| GHS | Category 1 | Category 2 | Category 3 | Category 4 | Category 5 |
LD50 ≤5 Danger Fatal if swallowed |
LD50 ≤50 Danger Fatal if swallowed |
LD50 ≤300 Danger Toxic if swallowed |
LD50 ≤2000 Warning Harmful if swallowed |
LD50 ≤5000 No symbol Warning May be harmful if swallowed |
|
| CC | Yes | Yes | Yes | Yes | Pending additional information |
| PCP | Yes | Yes | Yes | Yes | No |
| TDG* | Yes | Yes | Yes | No | No |
| WHMIS** | Yes | Yes | Yes | Still under discussion | Pending additional information |
*This shows the requirements of the 14th Revised Edition of the UN Model Regulations and will be reflected in a future amendment to TDG
** For mixtures: The WHMIS Current Issues Committee recommended the incorporation of bridging principles and formulae to calculate the acute toxicity estimate (ATE) be included in the proposed amendment to the WHMIS regulations (Controlled Products Regulations) upon GHS implementation.
Acute Toxicity: Skin (mg/kg)
| GHS | Category 1 | Category 2 | Category 3 | Category 4 | Category 5 |
| LD50 ≤50 Danger Fatal in contact with skin |
LD50 ≤200 Danger Fatal in contact with skin |
LD50 ≤1000 Danger Toxic in contact with skin |
LD50 ≤2000 Warning Harmful in contact with skin |
LD50 ≤5000 No symbol Warning May be harmful in contact with skin |
|
| CC | Yes | Yes | Yes | Yes | Pending additional information |
| PCP | Yes | Yes | Yes | Yes | No |
| TDG* | Yes | Yes | Yes | No | No |
| WHMIS | Yes | Yes | Yes | Still under discussion | Pending additional information |
*This shows the requirements of the 14th Revised Edition of the UN Model Regulations and will be reflected in a future amendment to TDG
Acute Toxicity: Inhalation - Gases (ppmV)
| GHS | Category 1 | Category 2 | Category 3 | Category 4 | Category 51 |
| LC50 ≤100 Danger Fatal if inhaled |
LC50 ≤500 Danger Fatal if inhaled |
LC50 ≤2500 Danger Toxic if inhaled |
LC50 ≤5000 Warning Harmful if inhaled |
No symbol Warning May be harmful if inhaled |
|
| CC | Yes | Yes | Yes | Yes | Pending additional information |
| PCP | Yes | Yes | Yes | Yes | No |
| TDG | Yes | Yes | Yes | Yes* | No |
| WHMIS | Yes | Yes | Yes | Still under discussion | Pending additional information |
1Guidance on Category 5 Inhalation Values: The OECD Task Force on Harmonisation of Classification and Labelling (HCL) did not include numerical values for acute inhalation toxicity class 5 but instead specified doses "equivalent" to the range of 2000-5000 mg/kg bodyweight by the oral or dermal route.
*TDG has no cut-points for inhalation of toxic gases and regulates to 5000 ppm. The TDG label for Category 4 is skull & crossbones.
Acute Toxicity: Inhalation - Vapours (mg/l)
| GHS | Category 1 | Category 2 | Category 3 | Category 4 | Category 51 |
| LC50 ≤0.05 Danger Fatal if inhaled |
LC50 ≤0.5 Danger Fatal if inhaled |
LC50 ≤1.0 Danger Toxic if inhaled |
LC50 ≤5 Warning Harmful if inhaled |
LC50 ≤10 No symbol Warning May be harmful if inhaled |
|
| CC | Yes | Yes | Yes | Yes | Pending additional information |
| PCP | Yes | Yes | Yes | Yes | No |
| TDG* | Yes | Yes | Yes | No | No |
| WHMIS** | Yes | Yes | Yes | Still under discussion | Pending additional information |
1Guidance on Category 5 Inhalation Values: The OECD Task Force on Harmonisation of Classification and Labelling (HCL) did not include numerical values for acute inhalation toxicity class 5 but instead specified doses "equivalent" to the range of 2000-5000 mg/kg bodyweight by the oral or dermal route.
* TDG regulates to 5000 ppm for the inhalation of toxic vapours. The TDG label for Category 4 is skull & crossbones.
** The WHMIS Current Issues Committee recommended eliminating the existing saturated vapour concentration (SVC) from the WHMIS classification criteria for this hazard class.
Acute Toxicity: Inhalation - Dusts & Mists (mg/l)
| GHS | Category 1 | Category 2 | Category 3 | Category 4 | Category 51 |
| LC50 ≤0.5 Danger Fatal if inhaled |
LC50 ≤2.0 Danger Fatal if inhaled |
LC50 ≤10.0 Danger Toxic if inhaled |
LC50 ≤20.0 Warning Harmful if inhaled |
No symbol Warning May be harmful if inhaled |
|
| CC | Yes | Yes | Yes | Yes | Yes |
| PCP | Yes | Yes | Yes | Yes | No |
| TDG | Yes | Yes | Yes | Yes* | No |
| WHMIS** | Yes | Yes | Yes | Still under discussion | Pending additional information |
1Guidance on Category 5 Inhalation Values: The OECD Task Force on Harmonisation of Classification and Labelling (HCL) did not include numerical values for acute inhalation toxicity class 5 but instead specified doses "equivalent" to the range of 2000-5000 mg/kg bodyweight by the oral or dermal route.
* This shows the requirements of the 14th Revised Edition of the UN Model Regulations and will be reflected in a future amendment to TDG
Skin Corrosion/Irritation
| GHS | Category 1A | Category 1B | Category 1C | Category 2 | Category 3 |
 Danger Causes severe skin burns and eye damage |
Danger Causes severe skin burns and eye damage |
Danger Causes severe skin burns and eye damage |
Warning Causes skin irritation |
Warning Causes mild skin irritation |
|
| CC | Yes | Yes | Yes | Yes | Pending additional information |
| PCP | Yes, Adopt 1A, 1B, 1C as Category 1 | Yes | Yes | ||
| TDG | Yes | Yes | Yes | No | No |
| WHMIS* | Yes, Adopt 1A, 1B, 1C as Category 1 | Yes | Yes | ||
*For Mixtures: The WHMIS Current Issues Committee recommended incorporation of the GHS bridging principles and "non-additivity" approach for classifying untested mixtures.
Serious Eye Damage/Irritation
| GHS | Category 1 | Category 2A | Category 2B |
| Danger Causes serious eye damage |
Warning Causes serious eye irritation |
Warning Causes eye irritation |
|
| CC | Yes | Yes | Yes |
| PCP | Yes | Yes | Yes |
| TDG | No | No | No |
| WHMIS** | Yes | Yes, Adopt 2A, 2B as Category 2 | |
** For Mixtures: The WHMIS Current Issues Committee recommended incorporation of the GHS bridging principles and "non-additivity" approach for classifying untested mixtures.
Respiratory Sensitization
As part of the implementation of the GHS in Canada, an Ad Hoc Expert Group on Chronic Hazards was established to examine the application of the GHS chronic and sub-chronic hazard classes to consumer chemical products. Currently, regulations for consumer chemical products do not cover these hazards. This Expert Group will provide recommendations back to the Consumer Chemical Sector Working Group.
| GHS | Category 1 |
 Danger May cause allergy or asthma symptoms or breathing difficulties if inhaled |
|
| CC | Pending discussion of ad hoc Expert Group on Chronic Hazards |
| PCP | Still under discussion |
| TDG | No |
| WHMIS* | Yes |
* For Mixtures: The WHMIS Working Group recommended the retention of the 0.1% cut-off value for solid/liquid and gaseous respiratory sensitizers and full labelling requirements for all mixtures that contain these sensitizers at concentrations ≥ 0.1%.
Skin Sensitization
As part of the implementation of the GHS in Canada, an Ad Hoc Expert Group on Chronic Hazards was established to examine the application of the GHS chronic and sub-chronic hazard classes to consumer chemical products. Currently, regulations for consumer chemical product do not cover these hazards. This Expert Group
| GHS | Category 1 |
Warning May cause an allergic skin reaction |
|
| CC | Pending discussion of ad hoc Expert Group on Chronic Hazards |
| PCP | Yes |
| TDG | No |
| WHMIS* | Yes |
will provide recommendations back to the Consumer Chemical Sector Working Group.
*For Mixtures: The WHMIS Working Group recommended a cut-off value of 0.1% with reduced labelling requirements for mixtures containing sensitizers at concentrations between 0.1% and 1.0%. Where an elicitation response is evident below 0.1%, the mixture should be classified and supplementary labelling used accordingly. Supplementary labelling here only includes a statement identifying the sensitizer present in the mixture.
Germ Cell Mutagenicity
As part of the implementation of the GHS in Canada, an Ad Hoc Expert Group on Chronic Hazards was established to examine the application of the GHS chronic and sub-chronic hazard classes to consumer chemical products. Currently, regulations for consumer chemical products do not cover these hazards. This Expert Group will provide recommendations back to the Consumer Chemical Sector Working Group.
| GHS | Category 1A | Category 1B | Category 2 |
Danger May cause genetic defects (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) |
Danger May cause genetic defects(state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) |
Warning Suspected of causing genetic defects(state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) |
|
| CC | Pending discussion of ad hoc Expert Group on Chronic Hazards | Pending discussion of ad hoc Expert Group on Chronic Hazards | Pending discussion of ad hoc Expert Group on Chronic Hazards |
| PCP* | Yes | Yes | Yes |
| TDG | No | No | No |
| WHMIS** | Yes, adopt 1A , 1B as Category 1 | Yes | |
*Classify for Safety Data Sheet purposes only. Do not adopt GHS labelling. Use risk based labelling.
**For Mixtures: The WHMIS Working Group recommended a cut-off value of 0.1% and 1.0% for classification of mixtures containing Category 1 and 2 mutagens, respectively.
Carcinogenicity
As part of the implementation of the GHS in Canada, an Ad Hoc Expert Group on Chronic Hazards was established to examine the application of the GHS chronic and sub-chronic hazard classes to consumer chemical products. Currently, regulations for consumer chemical products do not cover these hazards. This Expert Group will provide recommendations back to the Consumer Chemical Sector Working Group.
| GHS | Category 1A | Category 1B | Category 2 |
| Known human carcinogen Danger May cause cancer (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) |
Presumed human carcinogen Danger May cause cancer (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) |
Suspected human carcinogen Warning Suspected of causing cancer (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) |
|
| CC | Pending discussion of ad hoc Expert Group on Chronic Hazards | Pending discussion of ad hoc Expert Group on Chronic Hazards | Pending discussion of ad hoc Expert Group on Chronic Hazards |
| PCP* | Yes | Yes | Yes |
| TDG | No | No | No |
| WHMIS** | Yes, adopt 1A , 1B as Category 1 | Yes | |
*Classify for Safety Data Sheet purposes only. Do not adopt GHS labelling. Use risk based labelling.
** For Mixtures: The WHMIS Working Group recommended a cut-off value of 0.1% for classification of mixtures containing Category 1 and 2 carcinogens.
Toxic to Reproduction
As part of the implementation of the GHS in Canada, an Ad Hoc Expert Group on Chronic Hazards was established to examine the application of the GHS chronic and sub-chronic hazard classes to consumer chemical products. Currently, regulations for consumer chemical products do not cover these hazards. This Expert Group will provide recommendations back to the Consumer Chemical Sector Working Group.
| GHS | Category 1A | Category 1B | Category 2 |
| Known human reproductive or developmental toxicant Danger May damage fertility or the unborn child (state specific effect if known) (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) |
Presumed human reproductive or developmental toxicant Danger May damage fertility or the unborn child (state specific effect if known) (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) |
Suspected human reproductive or developmental toxicant Warning Suspected of damaging fertility or the unborn child (state specific effect if known) (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) |
|
| CC | Pending discussion of ad hoc Expert Group on Chronic Hazards | Pending discussion of ad hoc Expert Group on Chronic Hazards | Pending discussion of ad hoc Expert Group on Chronic Hazards |
| PCP* | Yes | Yes | Yes |
| TDG | No | No | No |
| WHMIS** | Yes, adopt 1A , 1B as Category 1 | Yes | |
*Classify for Safety Data Sheet purposes only. Do not adopt GHS labelling. Use risk based labelling.
** For Mixtures: The WHMIS Working Group recommended a cut-off value of 0.1% for classification of mixtures containing Category 1 and 2 reproductive toxicants.
Effects on or via Lactation
As part of the implementation of the GHS in Canada, an Ad Hoc Expert Group on Chronic Hazards was established to examine the application of the GHS chronic and sub-chronic hazard classes to consumer chemical products. Currently, regulations for consumer chemical products do not cover these hazards. This Expert Group will provide recommendations back to the Consumer Chemical Sector Working Group.
| GHS | Category 1 |
| No Symbol No Signal Word May cause harm to breast-fed children |
|
| CC | Pending discussion of ad hoc Expert Group on Chronic Hazards |
| PCP* | Yes |
| TDG | No |
| WHMIS** | Yes |
*Classify for Safety Data Sheet purposes only. Do not adopt GHS labelling. Use risk based labelling.
** For Mixtures: The WHMIS Working Group recommended a cut-off value of 0.1% for classification of mixtures containing substances classified under "effects on or via lactation".
Target Organ Systemic Toxicity (Single Exposure)
| GHS | Category 1 | Category 2 | Category 3 |
Danger Causes damage to (state all organs affected, or use a general statement where there is no definite evidence that other organs are not affected) if (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) |
Warning Causes damage to (state all organs affected, or use a general statement where there is no definite evidence that other organs are not affected) if (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) |
Warning May cause respiratory irritation or May cause drowsiness and dizziness |
|
| CC | Yes | Still under discussion | Still under discussion |
| PCP* | Yes | Yes | Still under discussion |
| TDG | No | No | TBD |
| WHMIS** | Yes | Yes | Yes |
* Classify for Safety Data Sheet purposes only. Do not adopt GHS labelling. Use risk based labelling.
** For Mixtures: The WHMIS Working Group recommended a 1.0% cut-off value for classification of mixtures containing Category 1 or 2 target organ / systemic toxicants.
Target Organ Systemic Toxicity (Repeated Exposure)
As part of the implementation of the GHS in Canada, an Ad Hoc Expert Group on Chronic Hazards was established to examine the application of the GHS chronic and sub-chronic hazard classes to consumer chemical products. Currently, regulations for consumer chemical products do not cover these hazards. This Expert Group will provide recommendations back to the Consumer Chemical Sector Working Group.
| GHS | Category 1 | Category 2 |
Danger Causes (state all organs affected, or use a general statement where there is no definite evidence that other organs are not affected) damage through prolonged or repeated exposure (state route of exposure if it is conclusively proven that no their routes of exposure cause the hazard) |
Warning Causes (state all organs affected, or use a general statement where there is no definite evidence that other organs are not affected) damage through prolonged or repeated exposure (state route of exposure if it is conclusively proven that no their routes of exposure cause the hazard) |
|
| CC | Pending discussion of ad hoc Expert Group on Chronic Hazards | Pending discussion of ad hoc Expert Group on Chronic Hazards |
| PCP* | Yes | Yes |
| TDG | No | No |
| WHMIS** | Yes | Yes |
* Classify for Safety Data Sheet purposes only. Do not adopt GHS labelling. Use risk based labelling.
** For mixtures: The WHMIS Working Group recommended a 1.0% cut-off value for classification of mixtures containing Category 1 or 2 repeated exposure target organ / systemic toxicants.
Aspiration Toxicity
| GHS | Category 1 | Category 2 |
Danger May be fatal if swallowed and enters airways |
Warning May be harmful if swallowed and enters airways |
|
| CC | Yes | Pending additional information |
| PCP | Still under discussion | Still under discussion |
| TDG | No | No |
| WHMIS | Still under discussion | Still under discussion |
