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Consumer Product Safety

Changes to the Cosmetic Ingredient Hotlist

For more information on the consultation comments provided to Health Canada, please contact the Hotlist Coordinator at: cosmetics@hc-sc.gc.ca.

Changes to the Cosmetic Ingredient Hotlist:

December 2015 Changes to the Cosmetic Ingredient Hotlist

Format Changes:

The table format has been further improved by removing repeated text and adding an extra column in the restricted table in order to highlight the maximum concentration permitted and entries have been reworded in order to ensure consistency and clarity.

Items Amended:

  • Methylisothiazolinone / Methylchloroisothiazolinone (MI/MCI), in combination. This entry was amended in order to add a new condition for MI/MCI when used in combination, as a prohibited substance in leave-on cosmetic products. The preservative can still be used in rinse-off products, to a maximum concentration of 0.0015% or 15 ppm.
  • Cyanoacrylate-based adhesives. This entry was amended in order to reflect the policy change in requirements for cyanoacrylate-based eyelash adhesives. Notifiers of cyanoacrylate-based adhesives for the application of false eyelashes will no longer be required to submit descriptions of their training methods and training materials to Health Canada upon notification. However, these materials should be kept on hand.
  • Peroxide and peroxide-generating compounds. In order to better reflect current use patterns for tooth whitening products, this entry was amended by updating the cautionary statements.
  • p-Phenylenediamine and its salts. This entry was amended in two ways:
    1. Addition of a maximum concentration limit of 3% after dilution with an oxidizer, and
    2. Addition of p-Phenylenediamine salts to the list of synonyms and related compounds.

Items Added:

  • Prostaglandins, their salts, derivatives and analogs. Prostaglandins and their analogs were added as a prohibited ingredient in cosmetic products due to their presence on the Prescription Drug List and their sole therapeutic functions.

April 2014 Changes to the Cosmetic Ingredient Hotlist

Format Changes:

The Hotlist is separated into two distinct tables, one for prohibited ingredients and another for restricted ingredients

Items Amended:

  • Alpha-hydroxy acids (AHAs). This entry has been amended to include an upper limit for AHAs in professional-use cosmetic products in addition to clarifying the types of evidence of safety required by Health Canada.
  • Formaldehyde (50-00-0).This entry has been amended to include the inhalation limit in topical non-aerosol cosmetics that are expected to release formaldehyde when used according to directions.
  • Retinol (68-26-8) and its esters. This entry has been amended to highlight the conversion factor between retinol and other retinol equivalents.

Items Added:

  • Solvent Red 23 (85-86-9). This ingredient has been added as a restriction due to health concerns and to reflect its proposed addition to Schedule 1 of the Canadian Environmental Protection Act (CEPA 1999), as assessed through the Government of Canada's Chemicals Management Plan.
  • Diethylhexyl Adipate (103-23-1). This ingredient has been added as a restriction due to health concerns and to reflect its proposed addition to Schedule 1 of the Canadian Environmental Protection Act (CEPA 1999), as assessed through the Government of Canada's Chemicals Management Plan.
  • Resorcinol (108-46-3). An individual entry for this ingredient has been added to better highlight the ingredient's restriction under the "coal tar dye" entry.
  • Methylene Glycol (463-57-0). An individual entry for this ingredient has been added to better highlight the ingredient's restriction under the "formaldehyde" entry.

March 2011 Changes to the Cosmetic Ingredient Hotlist

Items Amended:

  • 2-(4-Allyl-2-methoxyphenoxy)-N,N-diethylacetamide (estil) (305-13-5) and its salts. The entry for this ingredient has been amended to include a synonym.
  • Cannabis sativa seed oil (hemp seed oil) (8016-24-8, 89958-21-4). The entry for this ingredient has been amended to correct the CAS number.
  • Citric acid (77-92-9). An individual entry for this ingredient has been added to better highlight the ingredient's restriction under the "Alpha-hydroxy acids" entry.
  • 5,5'-Diisopropyl-2,2'-dimethylbiphenyl-4,4'-diyl dihypoiodite (thymol iodide) (552-22-7). The entry for this ingredient has been amended to include a synonym and a CAS number.
  • Estil (305-13-5) and its salts. The entry for this ingredient has been combined under "2-(4-Allyl-2-methoxyphenoxy)-N,N-diethylacetamide" for clarification.
  • Glycolic acid (79-14-1). An individual entry for this ingredient has been added to better highlight the ingredient's restriction under the "Alpha-hydroxy acids" entry.
  • Lactic acid (50-21-5). An individual entry for this ingredient has been added to better highlight the ingredient's restriction under the "Alpha-hydroxy acids" entry.
  • Methyl alcohol (67-56-1). The entry for this ingredient has been amended to clarify the requirements under the Cosmetic Regulations.
  • 2-Methyl-m-phenylenediamine (toluene-2,6-diamine) (823-40-5). The entry for this ingredient has been amended to include a synonym.
  • 4-Methyl-m-phenylenediamine (toluene-2.4-diamine) (95-80-7) and its salts. The entry for this ingredient has been amended to include a synonym.
  • Potassium bromate (7758-01-2). The entry for this ingredient has been amended to a prohibition due to health concerns and to reflect its addition to Schedule 1 of the Canadian Environmental Protection Act (CEPA 1999), as assessed through the Government of Canada's Chemicals Management Plan.
  • Toluene-2,4-diamine (95-80-7). The entry for this ingredient has been combined under "4-Methyl-m-phenylenediamine" for clarification.
  • Zirconium (7440-67-7) and its compounds. The entry for this ingredient has been amended for clarification.

Items Added:

  • Acrylamide monomer (79-06-1). This ingredient has been added as a prohibition due to health concerns and to reflect its proposed addition to Schedule 1 of the CEPA 1999, as assessed through the Government of Canada's Chemicals Management Plan.
  • Aluminum chloride (7446-70-0; 7784-13-6). This ingredient has been added as a restriction to reflect a change in the classification of antiperspirant products as per the Products at the Cosmetic-Drug Interface (PCDI) Product Assessment Against Criteria: Antiperspirants.
  • Aluminum chlorohydrate (12042-91-0) and its associated complexes. These ingredients have been added as a restriction to reflect a change in the classification of antiperspirant products as per the Products at the Cosmetic-Drug Interface (PCDI) Product Assessment Against Criteria: Antiperspirants.
  • Aluminum zirconium complexes. These ingredients have been added as a restriction to reflect a change in the classification of antiperspirant products as per the Products at the Cosmetic-Drug Interface (PCDI) Product Assessment Against Criteria: Antiperspirants.
  • Benzyl chloride (100-44-7). This ingredient has been added as a prohibition due to health concerns and to reflect its proposed addition to Schedule 1 of the CEPA 1999, as assessed through the Government of Canada's Chemicals Management Plan.
  • 4,4'-Bis(dimethylamino)benzophenone (Michler's ketone) (90-94-8). This ingredient has been added as a prohibition due to health concerns and to reflect its proposed addition to Schedule 1 of the CEPA 1999, as assessed through the Government of Canada's Chemicals Management Plan.
  • 1,3-Butadiene (106-99-0). This ingredient has been added as a prohibition due to health concerns and to reflect its proposed addition to Schedule 1 of the CEPA 1999, as assessed through the Government of Canada's Chemicals Management Plan.
  • Butane (106-97-8). This ingredient has been added as a restriction due to concerns with 1,3-butadiene impurities.
  • CI 12120 (pigment red 3) (2425-85-6). This ingredient has been added as a prohibition due to health concerns and to reflect its proposed addition to Schedule 1 of the CEPA 1999, as assessed through the Government of Canada's Chemicals Management Plan.
  • Diethyl sulfate (64-67-5). This ingredient has been added as a prohibition due to health concerns and to reflect its proposed addition to Schedule 1 of the CEPA 1999, as assessed through the Government of Canada's Chemicals Management Plan.
  • Dimethyl sulfate (77-78-1). This ingredient has been added as a prohibition due to health concerns and to reflect its proposed addition to Schedule 1 of the CEPA 1999, as assessed through the Government of Canada's Chemicals Management Plan.
  • Isobutane (75-28-5). This ingredient has been added as a restriction due to concerns with 1,3-butadiene impurities.
  • Methoxydiglycol (diethylene glycol monomethyl ether) (111-77-3). This ingredient has been added as a prohibition due to health concerns and to reflect its proposed addition to Schedule 1 of the CEPA 1999, as assessed through the Government of Canada's Chemicals Management Plan.
  • Methoxyethanol acetate (110-49-6). This ingredient has been added as a prohibition due to health concerns and to reflect its proposed addition to Schedule 1 of the CEPA 1999, as assessed through the Government of Canada's Chemicals Management Plan.
  • Methoxyisopropanol (propylene glycol monomethyl ether) (107-98-2). This ingredient has been added as a prohibition due to health concerns, as assessed by the Government of Canada's Chemicals Management Plan (CMP) under CEPA 1999.
  • Methoxyisopropyl acetate (propylene glycol monomethyl ether acetate) (108-65-6; 84540-57-8). The ingredient has been added as a prohibition due to health concerns, as assessed by the Government of Canada's Chemicals Management Plan (CMP) under CEPA 1999.
  • 2-Methoxypropanol (1589-47-5). This ingredient has been added as a prohibition due to health concerns and to reflect its proposed addition to Schedule 1 of the CEPA 1999, as assessed through the Government of Canada's Chemicals Management Plan.
  • 2-Methoxypropyl-1-acetate (70657-70-4). This ingredient has been added as a prohibition due to health concerns, as assessed by the Government of Canada's Chemicals Management Plan (CMP) under CEPA 1999.

June 2010 Changes to the Cosmetic Ingredient Hotlist

Items Amended:

  • Hydroquinone (123-31-9). The restriction for this ingredient has been amended to reflect its addition to Schedule 1 of the Canadian Environmental Protection Act (CEPA 1999), due to health concerns as assessed through the Government of Canada's Chemicals Management Plan.

Items Added:

  • Epichlorohydrin (Oxirane, (chloromethyl)) (106-89-8). This ingredient has been added as a prohibition due to health concerns to reflect its addition to Schedule 1 of the (CEPA 1999), as assessed through the Government of Canada's Chemicals Management Plan.
  • HC Blue No. 4 (158571-57-4). This ingredient has been added as a prohibition to reflect the addition of epichlorohydrin to Schedule 1 of the CEPA 1999, due to health concerns, as assessed through the Government of Canada's Chemicals Management Plan.
  • HC Blue No. 5 (68478-64-8, 158571-58-5). This ingredient has been added as a prohibition to reflect the addition of epichlorohydrin to Schedule 1 of the CEPA 1999, due to health concerns, as assessed through the Government of Canada's Chemicals Management Plan.
  • 4,4'-Isopropylidenediphenol (Bisphenol A) (80-05-7). This ingredient has been added as a prohibition to reflect its addition to Schedule 1 of the CEPA 1999, due to health concerns, as assessed through the Government of Canada's Chemicals Management Plan.
  • Isoprene monomer (1,3-Butadiene, 2-methyl) (78-79-5). This ingredient has been added as a prohibition to reflect its addition to Schedule 1 of the CEPA 1999, due to health concerns, as assessed through the Government of Canada's Chemicals Management Plan.
  • Methyloxirane monomer (propylene oxide) (75-56-9). This ingredient has been added as a prohibition to reflect its addition to Schedule 1 of the CEPA 1999, due to health concerns, as assessed through the Government of Canada's Chemicals Management Plan.
  • Naphthalene (91-20-3). This ingredient has been added as a prohibition to reflect its addition to Schedule 1 of the CEPA 1999, due to health concerns, as assessed through the Government of Canada's Chemicals Management Plan.
  • Toluene Diisocyanates (TDIs). These ingredients have been added as a prohibition to reflect their addition to Schedule 1 of the CEPA 1999, due to health concerns, as assessed through the Government of Canada's Chemicals Management Plan.

Items Deleted:

  • Siloxanes and Silicones, 3-[(2-aminoethyl)amino]-2-methylpropyl Me, di-Me, reaction products with N,N,N-trimethyloxiranemethanaminium chloride (495403-02-6), All references to activities on existing and potential cosmetic ingredients that have Significant New Activity (SNAc) notices under CEPA 1999 have been removed. Please contact the New Substances Program to find out which ingredients may be subject to notification or other action under CEPA 1999.

September 2009 Changes to the Cosmetic Ingredient Hotlist

Items Amended:

  • Alkali earth metal sulfides. The restriction for this ingredient has been amended for clarification.
  • Alkali sulfides. The restriction for this ingredient has been amended for clarification.
  • Alpha Hydroxy Acids. This restriction for this ingredient has been amended for clarification.
  • Androgenic effects. The restriction has been revised to include mention of some ingredients having androgenic effects.
  • Barium salts. The restriction for this ingredient has been amended for clarification.
  • Benzalkonium chloride (8001-54-5, 61789-71-7, 68391-01-5, 68424-85-1). The restriction for this ingredient has been amended to include a cautionary statement and for clarification regarding the chain length.
  • Coal tar dye, coal tar dye base or coal tar dye intermediate. The entry has been revised to include mention of some types of coal tar dye ingredients.
  • Fluoride (16984-48-8) containing substances. The restriction for this ingredient has been amended for clarification.
  • Formaldehyde (50-00-0). The restriction for this ingredient has been amended for clarification.
  • Gold Salts. The entry has been revised to include mention of some types of gold salt ingredients.
  • Nitrosamines. The entry for this ingredient category has been revised to include mention of a type of nitrosamine.
  • Potassium bromate (7758-01-2). The restriction for this ingredient has been amended for clarification as well as to correct the CAS number.
  • Sodium borate (1303-96-4). The entry for this ingredient has been revised to include common names of the ingredient.
  • Sodium bromate (7789-38-0). The restriction for this ingredient has been amended for clarification.
  • Spironolactone (52-01-7). The CAS number for this ingredient has been corrected.
  • Talc. The restriction for this ingredient has been amended for clarification.
  • Triclosan (3380-34-5). The restriction for this ingredient has been amended for clarification.
  • Urea (57-13-6). The restriction for this ingredient has been amended for clarification.
  • Zirconium (7440-67-7) and its compounds. The restriction for this ingredient has been amended based on acceptable limits of use in other jurisdictions as well as for clarification.

Items Added:

  • Cyanoacrylate-based adhesives.This ingredient has been added as a restriction due to safety concerns with products with quick skin bonding properties.
  • Diethylene glycol (DEG) (111-46-6). This ingredient has been added as a restriction due to toxicity concerns.
  • Diethylhexyl phthalate (DEHP) (117-81-7). This ingredient has been added as a prohibition to reflect its addition to Schedule 1 of the CEPA 1999, as assessed through the Government of Canada's Chemicals Management Plan.
  • Glycerin (56-81-5). This ingredient has been added as a restriction due to possible contamination of diethylene glycol (DEG) in glycerin.
  • 1-Naphthol (90-15-3), and its salts. This ingredient has been added as a restriction due to risk of sensitization.

Items Deleted:

  • Nail adhesives. The entry has been removed due to the addition of the "Cyanoacrylate-based adhesives" entry.

March 2007 Changes to the Cosmetic Ingredient Hotlist

Items Amended:

  • 2-(4-Allyl-2-methoxyphenoxy)-N,N-diethylacetamide (305-13-5). The CAS number for this ingredient has been added.
  • Camphor (76-22-2). The restriction for this ingredient has been amended based on data indicating potential hazards to children.
  • Croton tiglium oil (8001-28-3). The CAS number for this ingredient has been added.
  • Formaldehyde (50-00-0). The restriction for this ingredient has been amended for clarification.
  • Mercury (7439-97-6) and its compounds (including, but not limited to mercuric oxide (21908-53-2), phenyl mercuric acetate (62-38-4), phenyl mercuric benzoate (94-43-9), phenyl mercuric borate (102-98-7, 6273-99-0) and thimerosal (54-64-8)). The restriction for these ingredients has been amended to a prohibition due to the Health Canada mercury reduction strategy.
  • Methylisothiazolinone (2682-20-4)/ Methylchloroisothiazolinone (26172-55-4). The restriction for this ingredient combination has been amended for clarification.

Items Added:

  • Clostridium botulinum. This ingredient is restricted for use in cosmetic products based on the lack of a cosmetic purpose and data indicating links to toxicity.
  • Eucalyptus oil (8000-48-4). This ingredient was added based on data indicating potential hazards to children.
  • Methylisothiazolinone (2682-20-4). This ingredient was added to reflect applicable use.
  • Pueraria mirifica. This ingredient is not acceptable in cosmetic products due to its therapeutic properties.
  • Talc. This ingredient is restricted for use in baby products based on data indicating potential hazards to infants and children.

May 2005 Changes to the Cosmetic Ingredient Hotlist

Items Amended:

  • Bovine tissues and ingredients. The restriction for these ingredients has been amended to reflect the position of the Canadian Food Inspection Agency.
  • Coal tar dye. The restriction for these ingredients has been amended to permit use of specified dyes in the area of the eye.
  • Coal tars (crude and refined). These ingredients are no longer restricted but are prohibited for use in cosmetic products based on the lack of a cosmetic purpose and data suggesting links to carcinogenicity.
  • Lead acetate (301-04-2). This ingredient is no longer restricted but prohibited for use in cosmetic products based on data indicating skin absorption and possible links to carcinogenicity and reproductive toxicity.

Items Added:

  • Benzyl cyanide (140-29-4). This ingredient is not acceptable for use in cosmetic products based on data indicating the release of cyanide isometabolites.
  • Butoxyethanol (111-76-2). This ingredient is restricted for use in cosmetic products to reflect controls under the Canadian Environmental Protection Act.
  • Cannabis sativa seed oil (Hemp seed oil) (8016-24-8, 68956-68-3). This ingredient is restricted for use in cosmetic products to reflect controls under the Industrial Hemp Regulations.
  • Chloramine T (125-65-1). This ingredient is not acceptable for use in cosmetic products based on data indicating a risk of contact dermatitis.
  • Citrus reticulata leaf oil (8014-17-3). This ingredient is restricted for use in cosmetic products to reflect acceptable limits in other jurisdictions based on data indicating risk of phototoxicity.
  • Diethyl maleate (141-05-9). This ingredient is not acceptable for use in cosmetic products based on data indicating sensitization potential.
  • Dihydrocoumarin (119-84-6). This ingredient is not acceptable for use in cosmetic products based on data indicating sensitization potential.
  • 2,4-Dihydroxy-3-methylbenzaldehyde (6248-20-0). This ingredient is not acceptable for use in cosmetic products based on data indicating sensitization potential.
  • 4,6-Dimethyl-8-tert-butylcoumarin (17874-34-9). This ingredient is not acceptable for use in cosmetic products based on data indicating sensitization potential.
  • Dimethyl citraconate (617-54-9). This ingredient is not acceptable for use in cosmetic products based on data indicating sensitization potential.
  • 7,11-Dimethyl-4,6,10-dodecatrien-3-one (26651-96-7). This ingredient is restricted for use in cosmetic products based on data indicating sensitization potential.
  • 6,10-Dimethyl-3,5,9-undecatrien-2-one (141-10-6). This ingredient is not acceptable for use in cosmetic products based on data indicating sensitization potential.
  • Diphenylamine (122-39-4). This ingredient is not acceptable for use in cosmetic products based on data indicating sensitization potential.
  • Ficus carica leaf absolute (68916-52-9). This ingredient is not acceptable for use in cosmetic products based on data indicating photosensitization and phototoxicity potential.
  • trans-2-Heptenal (18829-55-5). This ingredient is not acceptable for use in cosmetic products based on data indicating sensitization potential.
  • Hydroabietyl alcohol (13393-93-6). This ingredient is not acceptable for use in cosmetic products based on data indicating sensitization potential.
  • Hydrolyzed Hemp seed protein. This ingredient is restricted for use in cosmetic products to reflect controls under the Industrial Hemp Regulations.
  • Indanedioxa. This ingredient is restricted for use in cosmetic products to reflect controls under the Canadian Environmental Protection Act.
  • Isophorone (78-59-1). This ingredient is not acceptable for use in cosmetic products based on data indicating possible carcinogenicity.
  • 6-Isopropyl-2-decahydronaphthalenol (34131-99-2). This ingredient is not acceptable for use in cosmetic products based on data indicating sensitization potential.
  • 7-Methoxycoumarin (531-59-9). This ingredient is not acceptable for use in cosmetic products based on data indicating photosensitization and phototoxicity potential.
  • 4-(4-Methoxyphenyl)-3-butene-2-one (943-88-4). This ingredient is not acceptable for use in cosmetic products based on data indicating sensitization potential.
  • α-Methylanisalacetone (104-27-8). This ingredient is not acceptable for use in cosmetic products based on data indicating sensitization potential.
  • Methyl-trans-2-butenoate (623-43-8). This ingredient is not acceptable for use in cosmetic products based on data indicating sensitization potential.
  • 5-Methyl-2,3-hexanedione (13706-86-0). This ingredient is not acceptable for use in cosmetic products based on data indicating sensitization potential.
  • Methyl N-methyl anthranilate (85-91-6). This ingredient is restricted for use in cosmetic products to reflect acceptable limits in other jurisdictions based on data indicating phototoxicity potential.
  • 2-Pentylidenecylclohexanone (25677-40-1). This ingredient is not acceptable for use in cosmetic products based on data indicating sensitization potential.
  • Phenol (108-95-2). This ingredient is not acceptable for use in cosmetic products based on the lack of a cosmetic purpose and data indicating links to toxicity.
  • Silicones and Siloxanes, 3-[(2-aminoethyl)amino]-2-methylpropyl Me, di-Me, reaction products with N,N,N-trimethyloxiranemethanaminium chloride (495403-02-6). This ingredient combination is restricted for use in cosmetic products to reflect controls under the Canadian Environmental Protection Act.
  • Tagetes oil (8016-84-0) and absolute. This ingredient is restricted for use in cosmetic products based on data indicating phototoxicity potential.
  • 3,6,10-Trimethyl-3,5,9-undecatrien-2-one (1117-41-5). This ingredient is not acceptable for use in cosmetic products based on data indicating sensitization potential.

December 2004 Changes to the Cosmetic Ingredient Hotlist

Items Amended:

  • Bovine tissues and ingredients. The restriction for these ingredients has been amended to a prohibition.
  • p-Hydroxyanisole (150-76-5). This ingredient is no longer prohibited but restricted based on acceptable limits of use in other jurisdictions.
  • Peroxides and peroxide generating substances. The restriction for these ingredients has been amended for clarification.
  • Thioglycolic acid (68-11-1). The restriction for this ingredient has been amended based on acceptable limits of use in other jurisdictions.
  • Triclosan (3380-34-5). The restriction for this ingredient has been amended on the French version to match the English version.

Items Added:

  • Acetylsalicylic acid (50-78-2). This ingredient poses a risk to consumers, and is therefore not acceptable for use in cosmetic products.
  • Analgesics. These ingredients are therapeutic, and are therefore not acceptable for use in cosmetic products.
  • 2-Bromo-2-nitropropane-1,3,-diol (52-51-7). This ingredient poses a risk to consumers, and is therefore restricted for use in cosmetic products.
  • Clobetasone (54063-32-0). This ingredient is therapeutic, and is therefore not acceptable for use in cosmetic products.
  • Methyl eugenol (93-15-2). This ingredient poses a risk to consumers, and is therefore restricted based on positions in other jurisdictions.
  • Mixed cresols (1319-77-3) and derivatives. These ingredients pose a risk to consumers, and are therefore not acceptable for use in cosmetic products.
  • Pheromones. These ingredients are hormones which are not acceptable for use in cosmetic products.
  • Steroids. These ingredients are therapeutic, and are therefore not acceptable for use in cosmetic products.
  • Symphytum spp., with the exception of Symphytum officinale. These ingredients pose a risk to consumers, and are therefore not acceptable for use in cosmetic products.
  • Tolnaftate (2398-96-1). This ingredient is therapeutic, and is therefore not acceptable for use in cosmetic products.

April 2004 Changes to the Cosmetic Ingredient Hotlist

Items Amended:

  • Alpha hydroxy acids. The restriction for citric acid (77-92-9) has been amended.
  • Bovine, ovine and caprine. The restriction for these ingredients has been amended (see Bovine tissues and ingredients).
  • Methoxyethanol (109-86-4). The CAS # for this ingredient has been corrected.
  • p-Phenylenediamine (106-50-3). The restriction for this ingredient has been amended.
  • Tetrachloroethylene (127-18-4). The CAS # for this ingredient has been corrected.

Items Added:

  • Creosote (wood creosote (8029-39-4), coal tar creosote (8001-58-9)). This ingredient has been identified as a carcinogen, and is therefore not acceptable for use in cosmetic products.
  • Estrogens. Estrogens is the North American name for "Oestrogens" which was listed on the previous "Hotlist".

Items Deleted:

  • Lycopene (502-65-8). This ingredient was misidentified as the International Nomenclature of Cosmetic Ingredient (INCI) name for tretinoin. Tretinoin remains on the "Hotlist" as a prohibited ingredient in cosmetic products.
  • Sodium Polystyrene Sulfonate (25704-18-1). This ingredient has been found to be acceptable for use in cosmetic products.