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Cosmetic Ingredient Hotlist - September 2009 - [A-C]

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  • Acenocoumarol (152-72-7)
  • Acetonitrile (75-05-8)
  • Acetylcholine (β-acetoxyethyl trimethyl ammonium hydroxide) (51-84-3)
  • Acetylsalicylic acid (50-78-2)
  • Aconitine (302-27-2) and its salts
  • Aconitum napellus L. leaves, roots and galenical preparations
  • Adonis vernalis L. and its preparations
  • Alkali earth metal sulfides (including, but not limited to barium sulfide (21109-95-5), calcium sulfide (20548-54-3), magnesium sulfide (12032-36-9), and strontium sulfide (1314-96-1))
    • Permitted at concentrations equal to or less than 6% sulfur in hair removal (depilatory) products only.
  • Alkali pentacyanonitrosylferrate (2-)
  • Alkali sulfides (including, but not limited to lithium sulfide (12136-58-2), potassium sulfide (1312-73-8), or sodium sulfide (1313-82-2))
    • Permitted at concentrations equal to or less than 2% sulfur in hair removal (depilatory) products only
  • O-Alkyldithiocarbonic acids, salts of
  • Alkyne alcohols and their esters, ethers and salts
  • Alloclamide (5486-77-1) and its salts
  • Allyl isothiocyanate (57-06-7)
  • 2-(4-Allyl-2-methoxyphenoxy)-N,N-diethylacetamide (305-13-5) and its salts
  • Alpha-hydroxy acids (AHAs) (including, but not limited to citric acid (77-92-9), glycolic acid (79-14-1), lactic acid (50-21-5), malic acid (6915-15-7), glycolic acid + ammonium glycolate, alpha-hydroxyethanoic acid + ammonium alpha-hydroxyethanoate, alpha-hydroxyoctanoic acid, alpha-hydroxycaprylic acid, hydroxycaprylic acid, mixed fruit acid, triple fruit acid, tri-alpha hydroxy fruit acids, alpha hydroxy and botanical complex, L-alpha hydroxy acid and glycomer in cross-linked fatty acids alpha nutrium)
    • Permitted at total concentrations equal to or less than 10%, with a pH equal to or greater than 3.5
    • Preparations containing higher concentrations of AHAs may be permitted for professional use if the manufacturer provides Health Canada with evidence of their safety, pH levels, and the directions for use.
    • The inner and outer labels of all leave-on skin products containing AHAs at concentrations equal to or greater than 3% shall carry cautionary statements to the effect: "Use only as directed", "Avoid contact with the eyes", "If irritation persists, discontinue use and consult a physician", "It is recommended that prior to exposure to the sun, users cover areas where AHAs have been applied with sunscreen", "Contact of the product with the skin must be of limited frequency and duration."
    • Preparations intended to be diluted in bath water may contain levels of citric acid exceeding 10%.
  • Ambenonium salts
  • 2-Amino-1,2-bis(4-methoxyphenol) ethanol (530-34-7) and its salts
  • Aminocaproic acid (1319-82-0) and its salts
  • 2-Amino-4-nitrophenol (99-57-0)
  • 2-Amino-5-nitrophenol (121-88-0)
  • 4-Amino-2-nitrophenol (119-34-6)
  • Aminophylline (58-55-9, 317-34-0)
  • 4-Aminosalicylic acid (65-49-6) and its salts
  • Amitriptyline (50-48-6) and its salts
  • Ammi majus and its galenical preparations
  • Amydricaine (alypine) (1,1-bis (dimethylaminomethyl) propyl benzoate) (963-07-5) and its salts
  • Amylocaine (644-26-8) and its salts
  • Anaesthetic effects, substances with
  • Analgesics
  • Anamirta cocculus L. fruit
  • Androgenic effects, substances with (including but not limited to testosterone (58-22-0) and prasterone (53-43-0))
  • Aniline (62-53-3), its salts and, its halogenated and sulfonated derivatives
  • Anthracene (120-12-7) oil
  • Antiandrogens with steroid structure
  • Antibiotics
  • Antihistamines
  • Antimony (7440-36-0) and its compounds
  • Apocynum cannabinum L. and its preparations
  • Apomorphine (58-00-4) and its salts
  • Apronalide (528-92-7)
  • Arecoline (63-75-2)
  • Aristolochic acid (313-67-7) and its salts
  • Arsenic (7440-38-2) and its compounds
  • Atropa belladonna L. and its preparations
  • Atropine (51-55-8), its salts and derivatives
  • Azacyclonol (115-46-8) and its salts
  • Azamethonium salts
  • Barbiturates
  • Barium salts
    • Permitted only as barium sulfide (21109-95-5) in hair removal products (see "Alkali earth metal sulfides"), as barium sulfate (7727-43-7), or as a colouring agent or lake for preparation of other colouring agents
  • Basic Violet 1 (CI 42535) (8004-87-3)
  • Basic Violet 3 (CI 42555, CI 42555:1, CI 42555:2) (548-62-9)
  • Basic Violet 10 (CI 45170) (81-88-9)
  • Bemegride (64-65-3)
  • Benactyzine (302-40-9)
  • Bendroflumethiazide (73-48-3) and its derivatives
  • Benzalkonium chloride (8001-54-5, 61789-71-7, 68391-01-5, 68424-85-1)
    • Permitted at concentrations equal to or less than 0.1% as a preservative only (i.e. benzalkonium chloride with chain lengths ≤ 14 C)
    • Permitted at concentrations equal to or less than 3% in rinse-off hair care products only, as a conditioning agent (i.e. benzalkonium chloride with chain lengths ≥ 16 C)
    • The inner and outer label of all products containing more than 0.1% benzalkonium chloride shall carry a cautionary statement to the effect: "Avoid contact with eyes."
  • Benzatropine (86-13-5) and its salts
  • Benzozepines
  • Benzene (71-43-2)
  • Benzethonium chloride (121-54-0)
    • Permitted at concentrations equal to or less than 0.2% in leave-on products and 0.3% in rinse-off products
    • Not permitted in products to be applied to mucous membranes
  • Benzidine (92-87-5)
  • Benzilonium bromide (1050-48-2)
  • Benzimidazol-2(3H)-one
  • Benzodiazepines
  • Benzoyl peroxide (94-36-0)
    • Permitted at concentrations equal to or less than 10% for use only as a catalyst in products to be applied to the fingernails or in hair dyes
    • Not permitted in products to be applied to the skin
  • Benzyl cyanide (140-29-4)
  • Benzylidene acetone (122-57-6)
  • 4-Benzyloxyphenol (monobenzone) (103-16-2)
  • Beryllium (7440-41-7) and its compounds
  • Betoxycaine (3818-62-0) and its salts
  • Bietamiverine (479-81-2)
  • Biphenamine (3572-52-9) and its salts
  • Bispyrithione (3696-28-4)
  • Bithionol (97-18-7)
  • Boric acid (10043-35-3, 11113-50-1) and its salts
    • Permitted at concentrations equal to or less than 5%
    • The label of the cosmetic shall carry cautionary statements to the effect: "Do not use on broken or abraded skin, not to be used by children under three years of age." Warning is not required when boric acid is used as a pH adjuster and the concentration is equal to or less than 0.1%
  • Bovine tissues and ingredients derived from the skull, brain, trigeminal ganglia, eyes, spinal cord, and dorsal root ganglia of cattle aged 30 months or older and the small intestine and tonsils of cattle of all ages
    • This prohibition does not apply to tallow derivatives, or to gelatin, collagen and hydrolyzed proteins prepared from bovine hides and skins.
  • Bretylium tosilate (61-75-6)
  • Bromine (7726-95-6), elemental
  • Bromisoval (496-67-3)
  • 2-Bromo-2-nitropropane-1,3-diol (52-51-7)
    • Permitted at concentrations equal to or less than 0.1%
    • Not permitted in formulations that contain amines or amides
  • 5-Bromo-5-nitro-1,3-dioxane (30007-47-7)
    • Permitted at concentrations equal to or less than 0.1%
    • Not permitted in formulations that contain amines or amides
  • Brompheniramine (86-22-6) and its salts
  • Brucine (357-57-3)
    • Permitted at concentrations equal to or less than 0.1%
  • Butanilicaine (3785-21-5) and its salts
  • Butopiprine (55837-15-5) and its salts
  • Butoxyethanol (111-76-2)
    • Permitted at concentrations equal to or less than 10% in hair dyes and nail products.
  • 1-Butyl-3-(N-crotonoylsulfanilyl) urea (52964-42-8)
  • 4-tert-Butylphenol (98-54-4)
  • 4-tert-Butylpyrocatechol (98-29-3)
  • Cadmium (7440-43-9) and its compounds
  • Calcium peroxide (calcium dioxide) (1305-79-9) (see peroxide and peroxide generating compounds).
  • Camphor (76-22-2)
    • Permitted at concentrations equal to or less than 3%
  • Cannabis sativa seed oil (Hemp seed oil) (8016-24-8, 68956-68-3)
    • Permitted at concentrations less than 10 μg/g THC (delta-9-tetrahydrocannabinol), as per the Industrial Hemp Regulations
  • Cantharides
  • Cantharidin (56-25-7)
  • Cantharis vesicatoria
  • Captan (N-(trichloromethylthiol)-4-cyclohexene-1,2-dicarboximide) (133-06-2)
  • Captodiame (486-17-9)
  • Caramiphen (77-22-5, 125-85-9) and its salts
  • Carbamide (urea) peroxide (124-43-6) (see "Peroxide and peroxide generating compounds")
  • Carbazole (86-74-8), nitroderivatives of
  • Carbon disulfide (75-15-0)
  • Carbon tetrachloride (56-23-5)
  • Carbromal (77-65-6)
  • Carbutamide (339-43-5)
  • Carisoprodol (78-44-4)
  • Catalase (9001-05-2)
    • The inner label and the outer label of the cosmetic shall carry a cautionary statement to the effect: "This product is not intended for use on broken or abraded skin."
  • Cephaeline (483-17-0) and its salts
  • Cephaelis ipecacuanha Brot. and related species roots, powder, and galenical preparations
  • Chenopodium ambrosioides essential oil (8006-99-3)
  • Chloral hydrate (302-17-0)
  • Chloramine T (127-65-1)
  • Chlorhexidine (55-56-1) and its salts
    • Permitted at concentrations equal to or less than 0.14%, calculated as chlorhexidine (55-56-1) free base; 0.19%, calculated as chlorhexidine diacetate (56-95-1); 0.20%, calculated as chlorhexidine digluconate (18472-51-0); and 0.16%, calculated as chlorhexidine dihydrochloride (3697-42-5)
  • Chlorine (7782-50-5)
  • Chlormethine (51-75-2) and its salts
  • Chlormezanone (80-77-3)
  • Chloroacetamide (79-07-2)
  • N-5-Chlorobenzoxazol-2-ylacetamide and its salts
  • Chloroethane (75-00-3)
  • N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts
  • Chloroform (67-66-3)
  • Chlorophacinone (2-(2-4-chlorophenyl)-2-phenylacetyl indan-1,3-dione) (3691-35-8)
  • Chlorphenoxamine (77-38-3)
  • Chlorpropamide (94-20-2)
  • Chlorprothixene (113-59-7) and its salts
  • Chlortalidone (77-36-1)
  • Chlorzoxazone (95-25-0)
  • Cholecalciferol (67-97-0)
    • Average daily absorption must be equal to or less than 25 μg per day
  • Choline (62-49-7) salts and their esters
  • Chromic acid (1308-14-1, 7738-94-5, 13530-68-2) and its salts
  • Chromium (7440-47-2)
  • Chrysoidine citrate hydrochloride
  • CI 12140 (3118-97-6)
  • CI 13065 (587-98-4)
  • CI 42640 (1694-09-3)
  • Cinchocaine (85-79-0) and its salts
  • Cinchophen (132-60-5), its salts, derivatives and salts of these derivatives
  • Citrus reticulata leaf oil (8014-17-3)
    • Permitted at concentrations equal to or less than 0.1% in leave-on products
  • Claviceps purpurea Tul., its alkaloids and galenical preparations
  • Clobetasone (54063-32-0)
  • Clofenamide (671-95-4)
  • Clofenotane (DDT) (50-29-3)
  • Clostridium botulinum
  • Coal tar dye, coal tar dye base or coal tar dye intermediate (including by not limited to toluene-2,5-diamine (95-70-5) and toluene-2,5-diamine sulfate (615-50-9)). See also "p-Phenylenediamine"
    • According to section 14 of the Cosmetic Regulations, "no person shall sell a cosmetic for use in the area of the eye that contains any coal tar dye, coal tar dye base or coal tar dye intermediate." "Area of the eye" is defined by the area bound by the supraorbital and infraorbital ridges and includes the eyebrows, the skin underlying the eyebrows, the eyelids, and eyelashes, the conjunctival sac of the eye, the eyeball and the soft tissue that lies below the eye and within the infraorbital ridge.
    • The following coal tar dyes are permitted in the area of the eye: Blue 1 (3844-45-9) and lake, Green 5 (4403-90-1), Red 40 (25956-17-6) and lake, Yellow 5 (1934-21-0) and lake.
    • Permitted in hair dye provided:
      1. the inner label and the outer label of the cosmetic shall carry statements to the effect:

        "CAUTION: this product contains ingredients that may cause skin irritation on certain individuals and a preliminary test according to accompanying directions should first be made. This product must not be used for dying the eyelashes or eyebrows. To do so, may cause blindness."

        "MISE EN GARDE: Ce produit contient des ingrédients qui peuvent causer de l'irritation cutanée chez certaines personnes: il faut donc d'abord effectuer une épreuve préliminaire selon les directives ci-jointes. Ce produit ne doit pas servir à teindre les sourcils ni les cils: en ce faisant, on pourrait provoquer la cécité."; and
      2. instructions to the following effect accompany each package of hair dye:
        1. the preparation may cause serious inflammation of the skin in some persons and a preliminary test should always be carried out to determine whether or not special sensitivity exists; and
        2. to make the test, a small area of skin behind the ear or on the inner surface of the forearm should be cleansed, using either soap and water or alcohol, and a small quantity of the hair dye as prepared for use should be applied to the area and allowed to dry. After 24 hours, the area should be washed gently with soap and water. If no irritation or inflammation is apparent, it is usually assumed that no hypersensitivity to the dye exists. The test should, however, be carried out before each application. On no account should the hair dye be used for dyeing eyebrows or eyelashes as severe inflammation of the eye or even blindness may result.
  • Coal tars (crude and refined) (8007-45-2)
  • Cobalt benzenesulfonate
  • Colchicine (64-86-8), its salts and derivatives
  • Colchicoside (477-29-2) and its derivatives
  • Colchicum autumnale L. and its galenical preparations
  • Coniferyl alcohol (4-hydroxy-3-methoxycinnamyl alcohol) (458-35-5), except for naturally occuring in plant extracts.
  • Coniine (458-88-8)
  • Conium maculatum L. fruit, powder and galenical preparations
  • Convallatoxin (508-75-8)
  • Coumetarol (4366-18-1)
  • Creosote (coal tar creosote (8001-58-9), wood creosote (8029-39-4))
  • Crimidine (2-chloro-6-methylpyrimidin-4-yldimethylamine) (535-89-7)
  • Croton tiglium oil (8001-28-3)
  • Curare (8063-06-7, 2251-14-9)
  • Curarine (22260-42-0)
  • Curarizants, synthetic
  • Cyanoacrylate-based adhesives including, but not limited to ethyl cyanoacrylate (7085-85-0), methyl cyanoacrylate (137-05-3), and isopropyl cyanoacrylate (10586-17-1)
    • For adhesives used for nail and hair (excluding those used in the area of the eye):
    • The inner and outer label of the cosmetic shall carry cautionary statements to the effect of:
      • "WARNING. BONDS SKIN INSTANTLY. AVOID CONTACT WITH EYES, MOUTH AND SKIN. KEEP AWAY FROM CHILDREN. Eyelid bonding: consult a physician. Skin bonding: soak and ease apart gently. Not for use in the area of the eye.
      • ATTENTION. COLLE INSTANTANÉMENT À LA PEAU. ÉVITER TOUT CONTACT AVEC LES YEUX, LA BOUCHE ET LA PEAU. TENIR HORS DE LA PORTÉE DES ENFANTS. Paupières collées: consulter un médecin. Peau collée: tremper et séparer graduellement. Ne pas utiliser dans la région oculaire."
    • For adhesives used in the area of the eye for the application of false eyelashes:
    • Manufacturers and/or distributors of glues must submit the following information to Health Canada to demonstrate safety of the product:
      • (a) Description of training method
        (b) Submission of all training materials
        (c) Description of measures taken by notifying company to limit the sale and access of the product to qualified and trained individuals.
    • The label of the cosmetic shall carry cautionary statements to the effect of:
      • "WARNING.  BONDS SKIN INSTANTLY. AVOID CONTACT WITH EYES, MOUTH AND SKIN. KEEP AWAY FROM CHILDREN.  Eyelid bonding: consult a physician. Skin bonding: soak and ease apart gently.
      • ATTENTION. COLLE INSTANTANÉMENT À LA PEAU. ÉVITER TOUT CONTACT AVEC LES YEUX, LA BOUCHE ET LA PEAU. TENIR HORS DE LA PORTÉE DES ENFANTS. Paupières collées : consulter un médecin. Peau collée : tremper et séparer graduellement."
    • Cyclarbamate (5779-54-4)
    • Cyclizine (82-92-8) and its salts
    • Cyclocoumarol (518-20-7)
    • Cyclomenol (5591-47-9) and its salts
    • Cyclophosphamide (50-18-0) and its salt
Date Modified: 2009-11-20

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