Proposed Maximum Residue Limit PMRL2013-20, Quizalofop-ethyl

Pest Management Regulatory Agency
17 April 2013
ISSN: 1925-0843 (PDF version)
Catalogue number: H113-24/2013-20E-PDF (PDF version)

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Under the authority of the  Pest Control Products Act, Health Canada's Pest Management Regulatory Agency (PMRA) has concluded that the addition of new uses on narrow leaf lupin to the product label of Assure® II Herbicide, containing technical grade quizalofop-p-ethyl, is acceptable. The specific uses approved in Canada are detailed on the label of Assure® II Herbicide, Pest Control Products Act Registration Number 25462.

The evaluation of this quizalofop-p-ethyl application indicated that the end-use product has merit and value and the human health and environmental risks associated with the new uses are acceptable.

Before registering a pesticide for food use in Canada, the PMRA must determine the quantity of residues that are likely to remain in or on the food when the pesticide is used according to label directions and that such residues will not be a concern to human health. This quantity is then legally established as a maximum residue limit (MRL). An MRL applies to the identified raw agricultural food commodity as well as to any processed food product that contains it, except where separate MRLs are specified for the raw agricultural commodity and a processed product made from it.

Residues of the resolved isomer quizalofop-p-ethyl are covered by MRLs established for quizalofop-ethyl, the unresolved isomeric mixture. Consultation on the proposed MRL for quizalofop-ethyl is being conducted via this document (see Next Steps). A summary of the field trial data used to support the proposed MRL can be found in Appendix 1.

To comply with Canada's international trade obligations, consultation on the proposed MRL is also being conducted internationally by notifying the  World Trade Organization, as coordinated by the  Standards Council of Canada.

The proposed MRL, to be added to the MRLs already established for quizalofop-ethyl, is as follows.

Table 1 - Proposed Maximum Residue Limits for Quizalofop-ethyl

Common Name	Residue Definition	MRL ((ppm))	Food Commodity
Table 1 footnotes Table 1 footnote 1 = parts per million Return to table 1 footnote ppm referrer
Quizalofop-ethyl	ethyl (RS) 2-[4-(6-chloroquinoxalin-2-yloxy)phenoxy]propionate, including the acid metabolites of (RS)2-[4-(6-chloroquinoxalin-2-yloxy)phenoxy]propanoic acid, all expressed as quizalofop-ethyl	0.15	Grain lupin

MRLs established in Canada may be found using the  Maximum Residue Limit Database on the Maximum Residue Limits for Pesticides webpage. The database allows users to search for pesticide(s) or for food commodity(ies).

International Situation and Trade Implications

MRLs may vary from one country to another for a number of reasons, including differences in pesticide use patterns and the locations of the field crop trials used to generate residue chemistry data.

Table 2 compares the MRL proposed for quizalofop-ethyl in Canada with corresponding American tolerance and Codex MRLs^{Footnote 1}. American tolerances are listed inthe  Electronic Code of Federal Regulations, 40 CFR Part 180, by pesticide. A listing of established Codex MRLs is available on the Codex Alimentarius  Pesticide Residues in Food website, by pesticide or commodity.

Table 2 - Comparison of Canadian MRLs, American Tolerances and Codex MRLs (where different)

Food Commodity	Canadian MRL (ppm)	American Tolerance (ppm)	Codex MRL (ppm)
Grain lupin	0.15	0.4 in/on Bean, dry, seed	Not Established

Next Steps

The PMRA invites the public to submit written comments on the proposed MRL for quizalofop-ethyl up to 75 days from the date of publication of this document. Please forward your comments to Publications. The PMRA will consider all comments received before making a final decision on the proposed MRL. Comments received will be addressed in a separate document linked to this PMRL. The established MRL will be legally in effect as of the date that they are entered into the  Maximum Residue Limit Database.

Appendix I - Summary of Field Trial Data Used to Support the Proposed MRL

Previously reviewed residue data from field trials conducted in Canada in/on dry beans were reassessed in the framework of this petition.

Maximum Residue Limit

The recommendation for a maximum residue limit (MRL) for quizalofop-ethyl was based upon the residues observed in dry beans treated according to label directions from field trial residue data on file. Table A1 summarizes the residue data used to calculate the proposed MRL.

Table A1 - Summary of Field Trial and Processing Data Used to Support Maximum Residue Limit (MRL)

Commodity	Application Method/Total Application Rate (g a.i./ha)	PHI (days)	Residues (ppm)		Experimental Processing Factor
			Min	Max
Dry beans	Foliar application/72	30-33	<0.05	0.11	Not applicable

Following the review of all available data, an MRL of 0.15 ppm is recommended to cover residues of quizalofop-p-ethyl and its acid metabolites (expressed as quizalofop-ethyl). Residues of quizalofop-p-ethyl and its acid metabolites (expressed as quizalofop-ethyl) in grain lupin at the proposed MRL will not pose an unacceptable risk to any segment of the population, including infants, children, adults and seniors.