Index of Published Canadian Adverse Reaction Newsletters

January 2010; 20(1)
Black cohosh products and liver toxicity: update
Canada Vigilance Online Database
Case presentation: Denture adhesive creams and neuropathy
Summary of advisories

October 2009; 19(4)
Intravenous immune globulin (IVIG): hemolytic reactions
Antiviral medications and influenza A (H1N1): reporting adverse reactions
Sildenafil (Revatio): medication incident
Adverse reaction reporting form
Summary of advisories

July 2009; 19(3)
Montelukast (Singulair): psychiatric reactions
Intravitreal injection of triamcinolone acetonide: ocular reactions
Fentanyl transdermal patches and accidental child exposure
Summary of advisories

April 2009; 19(2)
Atypical antipsychotics and agranulocytosis
Adverse reaction and incident reporting - 2008
Announcement: Cough and cold products
Case presentation: 5-Hour Energy drink and a cardiovascular adverse reaction
Adverse reaction reporting form
Summary of advisories

January 2009; 19(1)
Local anesthetic infusion with pain pumps and chondrolysis
Natural health products and adverse reactions: update
Case presentation: Propolis and renal failure
Summary of advisories

October 2008; 18(4)
Botulinum toxin type A and distant toxin spread
Case presentation: IVIG and transfusion-related acute lung injury
Cesium chloride and ventricular arrhythmias
Summary of advisories

July 2008; 18(3)
Fentanyl transdermal patch and fatal adverse reactions
Atomoxetine and suicidal behaviour: update
Twinject auto-injector and device malfunctions
Summary of advisories

April 2008; 18(2)
Varenicline and serious psychiatric reactions
Serious adverse reaction and medication incident
Adverse reaction reporting - 2007
Summary of advisories

January 2008; 18(1)
IVIG: myocardial infarction and cerebrovascular and thrombotic adverse reactions
Case presentation: NuvaRing and aortic thrombosis
Canada Vigilance Program
Evra: myocardial infarction and thromboembolic adverse reactions
Summary of advisories

October 2007; 17(4)
Gadolinium-containing agents: update on nephrogenic systemic fibrosis
Sibutramine and cardiovascular adverse reactions
Swedish Adjustable Gastric Band and erosion
Summary of advisories

July 2007; 17(3)
Benadryl Total: medication incident and stroke
Rosiglitazone and parotid gland enlargement: update
Adverse reaction reporting: education modules
Case presentation: Norethindrone and decreased breast milk production
Summary of advisories

April 2007; 17(2)
Quetiapine: pancreatitis and thrombocytopenia
Case presentation: Telithromycin and toxic epidermal necrolysis
Bitter orange (synephrine): update on cardiovascular reactions
Adverse reaction reporting - 2006
Summary of advisories

January 2007; 17(1)
Levofloxacin: dysglycemia and liver disorders
Domperidone: heart rate and rhythm disorders
Case presentation: Green tea extract and hepatotoxicity
Summary of advisories

October 2006; 16(4)
BioGlue: chronic inflammation and foreign-body reactions
New tool for reporting adverse reactions
Physician reporting of adverse reactions
Case presentation: Atomoxetine and tics
Summary of advisories

July 2006; 16(3)
Adverse reactions in children: Why report?
Case presentations:
Extended-release methylphenidate withdrawal: priapism
Iodoquinol: hypertensive encephalopathy and seizures
Symposium on drug, food and natural health product interactions
Summary of advisories

April 2006; 16(2)
Tenofovir and NSAIDs: acute renal failure
Adverse reaction reporting - 2005
Isotretinoin: myocardial infarction, cerebrovascular and thromboembolic disorders
Case presentation: Overnight orthokeratology and Acanthamoeba keratitis
Regional Adverse Reaction Centres: relocation
Summary of advisories

January 2006; 16(1)
Oseltamivir and warfarin: increase in INR
Levonorgestrel-releasing intrauterine system and uterine perforation
Guidance document for industry
Energy drinks
Case presentation: Rosiglitazone: parotid gland enlargement
Summary of advisories

October 2005; 15(4)
Intrathecal baclofen: pump system incidents
Statins and memory loss
Chloral hydrate and potassium chloride: medication incident
Case presentation: Ayurvedic medicines: lead contamination
New MedEffect e-notice and Web site
Summary of advisories

July 2005; 15(3)
Transdermal fentanyl: abuse in adolescents
Black cohosh: international reports of liver toxicity
Rosiglitazone: decreased HDL cholesterol levels
Ibuprofen: Stevens-Johnson syndrome
New Regional Adverse Reaction Centres
Case presentation: mefloquine with QT prolongation
Summary of advisories

April 2005; 15(2)
Hylan G-F 20 : joint inflammation and pain
Adverse reaction reporting - 2004
Products derived from bees: serious adverse reactions
Case presentation : rhabdomyolysis with clopidogrel, atorvastatin and cyclosporine
Summary of advisories

January 2005; 15(1)
Telithromycin and warfarin
Linezolid and neuropathy
Camphor and eucalyptus oils
Adverse reaction reporting
Natural weight loss product and myopathy
Ceftriaxone and immune hemolytic anemia in children
Case presentation :
olanzapine and pulmonary embolism
Summary of advisories

October 2004; 14(4)
Transdermal fentanyl (Duragesic): respiratory arrest in adolescents
Infliximab (Remicade) and etanercept (Enbrel): serious infections and tuberculosis
Bitter orange (synephrine): cardiovascular reactions
Case presentations:
Ibutilide and torsades de pointes
Tubersol and anaphylaxis
Summary of advisories

July 2004; 14(3)
Fluoroquinolones and warfarin: suspected interactions
Suspected warfarin-cranberry juice interaction
Case presentations:
     - Tutoplast Dura graft and Creutzfeldt-Jakob disease
     - Toxic shock syndrome and tampons
Summary of advisories

April 2004; 14(2)
Sterol and sterolin-containing products: hematologic adverse reactions
Adverse reaction reporting - 2003
Feasibility study of active surveillance of adverse reactions in children
Public opinion survey on post-market surveillance
Case presentation: clopidogrel
Summary of advisories

January 2004; 14(1)
Valdecoxib (Bextra^TM): severe cutaneous reactions
Natural health products
Case presentations:
     - Ciprofloxacin
     - Finasteride
Drug Safety Information Workshop II Report
Human growth hormone (somatropin): Prader-Willi syndrome
Summary of advisories

October 2003; 13(4)
Bisphosphonates and ocular disorders
Fluticasone and adrenal suppression
Adhesion prevention solutions in gynecological procedures
Case presentation: intravenous immunoglobulins
Summary of Advisories
Insulin products

July 2003; 13(3)
Gatifloxacin (Tequin^TM ): hypoglycemia and hyperglycemia
Serotonin syndrome
Summary of advisories
Case presentation: red yeast rice and rhabdomyolysis

April 2003; 13(2)
Withdrawal reactions with paroxetine and other SSRIs
Adverse reaction reporting - 2002
Case presentation: divalproex
Safe use of products containing acetaminophen
Hormone replacement therapy
Summary of advisories

January 2003; 13 (1)
Suspected hepatobiliary reactions to the newer antidepressants
Convulsions and newer-generation antihistamines
Drug Safety Information Workshop Report
Case presentation: RespirActin
Summary of advisories

October 2002; 12 (4)
Natural Health Products: adverse reactions
Leflunomide (Arava): hematologic, hepatic and respiratory reactions
Case Presentation: moxifloxacin
Summary of Advisories
Drugs and grapefruit: interactions

July 2002; 12 (3)
Pure red cell aplasia and Eprex
Glitazones: update on adverse reactions
Safety of human insulins
Case presentation : Kava
Summary of Advisories

April 2002; 12 (2)
Marketed Health Products Directorate
Selective COX-2 inhibitors
Summary of advisories
Oral sodium phosphates solutions
Case presentation
Adverse reaction reporting - 2001

January 2002; 12 (1)
Statins: rhabdomyolysis and myopathy
Alendronate: suspected pancreatitis
HIV-associated lipodystrophy syndrome: overview and summary of case reports
Summary of drug advisories
Communiqué - Ibuprofen pediatric oral liquid: gastrointestinal bleeding

October 2001; 11(4)
Antitubercular drugs: hepatobiliary reactions
Electronic subscription to this Newsletter and drug advisories
Health professional advisories
Atypical antipsychotics: impaired glucose metabolism
Communiqué - Brimonidine (Alphagan) ophthalmic drops: accidental ingestion

July 2001; 11(3)
Drug advisories now available on the Web
Miconazole-warfarin interaction: increased INR
New toll-free numbers to report ADRs
Rosiglitazone (Avandia): hepatic, cardiac and hematological reactions
Adverse drug reaction reporting - 2000: Part 2
Communiqué
- Orlistat (Xenical) interaction with coumarin derivatives: increased INR
- Azithromycin (Zithromax): myocardial infarction
Drugs of Current Interest

April 2001; 11(2)
Adverse drug reaction reporting - 2000: Part 1
Antiparkinsonian drugs and "sleep attacks"
Rofecoxib (Vioxx): a year in review
Communiqué - Warfarin and glucosamine: interaction
Drugs of Current Interest

January 2001; 11(1)
Thioridazine (Mellaril) and mesoridazine (Serentil): prolongation of the QTc interval
Clopidogrel (Plavix): hematological reactions
Gentamicin ear drops and ototoxicity: update
Drugs of Current Interest

October 2000; 10(4)
New influenza drugs: unexpected serious reactions
Intravenous Rh_O [D] immune globulin [human]: suspected hemolytic/renal adverse reactions
Abboject® Unit-of-Use Syringe: reports of malfunction
Communiqué
- Glucosamine sulfate: hyperglycemia
                    - Ketotifen (Zaditen®): sleep apnea
                    - Diclofenac (Voltaren Ophtha®) and ketorolac
                      tromethamine (Acular®): corneal ulceration
Drugs of Current Interest

July 2000; 10 (3)
St. John's wort: harmful drug interaction
Olanzapine (Zyprexa): suspected serious reactions
Sildenafil (Viagra): cardiac risks
New Bureau Name
Communiqué
- Citalopram (Celexa) and clarithromycin (Biaxin): interaction
- Itraconazole (Sporanox): serum sickness-like disorder
Drugs of Current Interest

April 2000; 10 (2)
Adverse drug reaction reporting - 1999
Celecoxib (Celebrex): 1 year later
Correction - ticlopidine
Communiqué - orlistat (Xenical): pancreatitis
Drugs of Current Interest

January 2000; 10 (1)
Cisapride (Prepulsid): interactions
Pemoline (Cylert): market withdrawal
Bupropion (Zyban): update
Communiqué
- HIV protease inhibitors: paronychia
                    - Gingko biloba: bleeding disorders
Drugs of Current Interest

October 1999;9(4)
Serious hematologic reactions associated with ticlopidine - update
Leukotriene receptor antagonists: suspected adverse reactions
Communiqué - Ropinirole (Requip): sleep disorder

July 1999; 9(3)
Alteplase (Activase rt-PA) for acute ischemic stroke
Abciximab (ReoPro): risk of acute thrombocytopenia
Nefazodone (Serzone) and hepatotoxicity
Communiqué - Amlodipine (Norvasc): hearing loss

April 1999; 9(2)
Bupropion (Zyban): suspected adverse reactions
1998 ADR Statistics
Updates: immune globulin IV products, tolcapone (Tasmar)
Communiqué - Olanzapine (Zyprexa): priapism

January 1999; 9(1)
Isotretinoin and depression
Low-dose ASA and GI Bleeding
Guidelines for reporting ADRs
Communiqué - azithromycin, pentoxifylline, sertraline and carbamazepine: interaction

October 1998; 8(4)
Recent News About Drug Risks
New Ontario Regional ADR Centre
Discontinuation Reactions Associated With SSRIs
Communiqué - amantadine and warfarin, pantoprazole

July 1998; 8(3)
Quality Information in Spontaneous Reports
Donepezil: Suspected Adverse Reactions
Olanzapine: Hematological Reactions
Communiqué - valproic acid, cefaclor, latanoprost, protease inhibitors

April 1998; 8(2)
Alendronate-induced esophagitis
1997 ADR statistics
Communiqué - dorzolamide hydrochloride, hydroxychloroquine sulfate, torvastatin calcium, risperidone, venlafaxine hydrochloride

January 1998; 8(1)
Drugs: QT interval prolongation and torsades de pointes
Ciprofloxacin use in epileptic patients taking phenytoin
Appetite suppressants - update
Communiqué - vigabatrin, mefloquine, lamotrigine

October 1997; 7(4)
Calcium-channel blockers
Azithromycin - severe iatrogenic hepatitis
Newsletter survey results
Communiqué - protease inhibitors, vigabatrin, terconazole, Fen-phen, heparin, paroxetine

July 1997; 7(3)
ACE inhibitors and bronchospasm
Interferon beta-1b
Radiopharmaceuticals
New Expert Advisory Committee on Pharmacovigilance

April 1997; 7(2)
Adverse drug reaction reporting - 1996
Potential abuse of butorphanol nasal spray
Aminoglycoside ear drops and ototoxicity

January 1997; 7(1)
Primary pulmonary hypertension and appetite suppressants
HIV protease inhibitors and increased bleeding in hemophilia?
Erythema multiforme and nifedipine
Congenital anomalies and fluconazole

October 1996; 6(4)
Cefaclor-associated serum sickness-like reaction
Newsletter Assessment - Questionnaire

July 1996; 6(3)
Cisapride: Arrhythmia Awareness
Midazolam: A Wake-Up Call
Clarithromycin: Tooth Discolouration and Smell Alteration

April 1996; 6(2)
Metformin: Lactic Acidosis
Nefazodone: ADR Profile
1995 Statistics ADR or Product Fault?

January 1996; 6(1)
Cotrimoxazole
Nicotine Patches and exercise
Terbinafine - hepatobiliary reactions
SSRIs - hyponatremia

October 1995; 5(4)
Update: Fertility Drugs
Propofol: Convulsions
Contraindications: Dinoprostone
Vaginal Gel
DOCI List

July 1995; 5(3)
Reporting Adverse Drug Reactions
Lamotrigine (Lamictal): rashes
Drug Names: confusion from two fronts
Tiaprofenic Acid: cystitis
Ticlopidine: revisited
DOCI List

April 1995; 5(2)
Zidovudine: Benefits of use during pregnancy
Serevent®: Patient warnings must be stressed
Fluoroquinolones: Tendonitis
Topical Antifungals: Recent switch to over-the-counter
Phenazopyridine: Hemolytic anemia

January 1995; 5(1)
Risperidone and EPS Sumatriptan and migraine exacerbation
Bromocriptine
Fertility drug awareness
New regional centre for Quebec

October 1994; 4(3)
Regional Centres
New Drugs - Serzone, Neurontin, Sabril
Drugs of current interest

July 1994; 4(2)
Editorial Note
Terbinafine Herbal preparations

March 1994; 4(1) Rhabdomyolysis and HMG-CoA
Reductase Inhibitors
Antidepressants and Suicide
Help Wanted: Risperdal

November 1993; 3(2)
Ticlopidine HCl - Hematological and Liver Effects
H1-Antihistamines - Cardiotoxic Effects

August 1993; 3(1)
ACE Inhibitors: Renal Effects
Sumatriptan Succinate: Chest Pain
Nicotine Patches: Update / Inadvertent Exposure

April 1992; 2(1)
ADR Program, 1991 Annual Report
Case Report: Drug Interactions with Omeprazole
Vasospasm with B-Blockers
GI Bleeding with Toradol®

August 1991; 1(2)
PPSP Workshop Minocycline - Case reports of severe liver and renal reactions
ADRs in the Elderly Ciprofloxacin - ADR profile Diclofenac - Hepatic reactions

January 1991; 1(1)
Saskatchewan ADR Pilot Project
The WHO Connection Working Group on ADR Assessment