Table 1: Cases of potential lipodystrophy syndrome* associated with antiretroviral drugs reported to the CADRMP up to Aug. 31, 2001
| Case | Age/ sex | Reported clinical reactions† |
Reported metabolic reactions† | Concomitant drugs | Duration of treatment |
Suspect drug reported | |
|---|---|---|---|---|---|---|---|
| PI | NRTI | ||||||
| 1 | 56/F | Lipodystrophy | Diabetes mellitus | Lamivudine, nadolol, Prevacid, Zoloft | NA | - | Stavudine |
| 2 | 33/M | Fat disorder | Hyperglycemia | Lamivudine, stavudine | 26 wk | Indinavir | - |
| 3 | 44/M | Fat disorder | Hyperglycemia, hypertriglyceridemia | Nelfinavir | NA | Saquinavir | - |
| 4 | 49/M | Lipodystrophy, enlarged abdomen |
Hypertriglyceridemia | Azithromycin, lamivudine, saquinavir, stavudine | Continuing | Ritonavir | - |
Note:
CADRMP = Canadian Adverse Drug Reaction Monitoring Program, PI = protease inhibitor,
NRTI = nucleoside reverse transcriptase inhibitor, NA = not available.
*
Met working case definition: at least one clinical feature and at least
one metabolic abnormality, and no AIDS-defining event or other severe clinical
illness or use of anabolic steroids, glucocorticoids or immune modulators
within 3 months of assessment.
†
Based on the "preferred term" of the World Health Organization Adverse
Reaction Dictionary (WHOART).