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Summary of Study Outcomes for Adjuvant Therapy of Early Breast Cancer
		ATAC						BIG 1-98				IES				MA17
		Primary analysis		First Update		Treatment completion		Primary analysis		Update: monotherapy arms only		Second interim		Update		First interim		Update
Median F/U		33 months		47 months		68 months		26 months		51 months		30.6 months		56 months		28 months		28 months
Study Tx		Ana	Tam	Ana	Tam	Ana	Tam	Let	Tam	Let	Tam	Exe	Tam	Exe	Tam	Let	Pl	Let	Pl
# subjects		3125	3116	3125	3116	3125	3116	4003	4007	2463	2459	2362	2380	2352	2372	2575	2582	2583	2587
D F S	# events	317	379	413	472	575	651	351	428	352	418	183	266	354	455	75	132	92	155
	Absolute diff	2.0% at 3 years (89.4% vs 87.4%)		2.9% at 4 years (86.9% vs 84.5%)		Not reported		2.6% at 5 years (84.0% vs 81.4%)		2.9% at 5 years (84.0% vs 81.1%)		4.7% at 3 years (91.5% vs 86.8%)		3.3% at 2.5 years, 3.4% at 5 years		6.0% at 4 years (92.8% vs 86.8%)		4.6% at 4 years (94.4% vs 89.8%)
	HR	0.83 (0.71-0.96), p=0.01		0.86 (0.76-0.99), p=0.03		0.87 (0.78-0.97), p=0.01		0.81 (0.70-0.93), p=0.003		0.82 (0.71-0.95), p=0.007		0.68 (0.56-0.82), p=0.00005		0.76 (0.66-0.88), p=0.0001		0.57 (0.43-0.75), p=0.00008		0.58 (0.45-0.76), p<0.001
OS OS	# events	200	203	Not reported		831 in total		166	192	194	211	93	106	222	261	31	42	51	62
OS OS	HR	Not calculated yet		Not calculated yet		0.97 (0.85-1.12), p=0.7		0.86 (0.70-1.06), p=0.16		0.91 (0.75-1.11), p=0.35		0.88 (0.67-1.16), p=0.37		0.85 (0.71-1.02), p=0.08		0.76 (0.48-1.21), p=0.25		0.82 (0.57-1.19), p=0.3
DDFS		Not calculated yet		Not calculated yet		0.94 (0.83-1.06), p=0.3		0.83 (0.72-0.97), p=0.02		0.87 (0.75-1.01), p=0.07		0.66 (0.52-0.83), p=0.0004				Not reported		0.60 (0.43-0.84), p=0.002
TTDR						0.86 (0.74-0.99), p=0.04		0.73 (0.61-0.88), p=0.001		0.81 (0.67-0.98), p=0.03				0.83 (0.71-0.99), p=0.03