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Long description - Guidance Document: Conduct and Analysis of Comparative Bioavailability Studies

  1. The difference is equal to the test mean minus the reference mean which is equal to 5.3903 minus 5.5217 which equals -0.1314
  2. The standard error of the difference equals the square root of open bracket 2 times the mean square residual divided by the sample size close bracket which equals the square root of open bracket 2 times 0.0729 divided by 16 close bracket which equals 0.0955
  3. The area under the curve ratio equals 100 times e to the power of the difference which equals 100 times e to the power of open bracket 5.3908 minus 5.5217 close bracket which equals 87.68 percent
  4. 90% confidence limits
  5. Lower, Upper equals 100 times e to the power of open bracket the difference plus or minus t-statistic, where alpha is equal to 0.05 and degrees of freedom is equal to 14, times the standard error of the difference close bracket
  6. Lower equals 100 times e to the power of open bracket -0.1314 minus 1.761 times 0.0955 close bracket which equals 75.41 percent
  7. Upper equals 100 times e to the power of open bracket -0.1314 plus 1.761 times 0.0955 close bracket which equals 103.74 percent