Drug interactions with Natural Health Products: A Discussion Paper (November 2001)

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Report prepared by Heather Boon, BScPhm, PhD
Faculty of Pharmacy, University of Toronto

and

Tannis Jurgens, BScPhm, MSc, PhD
College of Pharmacy, Dalhousie University

November 2001

The views expressed in this paper are those of the authors and do not necessarily represent those of Health Canada

This report was commissioned by the Natural Health Products Directorate (Health Canada) to provide background reading for participants invited to attend a two-day conference to discuss natural health product/drug interactions and provide recommendations to the Directorate with respect to future initiatives in this area. The proceedings and recommendations from this conference will be available from the Natural Health Products Directorate (Health Canada) in the spring of 2002. The conference is scheduled for January 2002.

Please note: On April 1, 2002, the Marketed Health Products Directorate (MHPD) was created within the Health Products and Food Branch. The important role played by the MHPD in the monitoring and reporting of drug interactions with natural health products means that some of the information related to health systems is dated and may no longer be accurate.

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Table of Contents

1.0 Executive Summary
2.0 Introduction
3.0 Biomedical Issues
4.0 Clinical Issues
5.0 Health System and Policy Issues
6.0 Knowledge Transfer Issues
7.0 Conclusions
8.0 References
Appendix 1. Theoretical and/or reported drug interactions with St. John's wort
Appendix 2. Theoretical and/or reported herb/drug interactions with ginseng
Appendix 3. Recommended Resources
Appendix 4. Canadian ADR Reporting Centres
Appendix 5. Health Canada ADR Reporting Form