Appendix 5 - List of "Key" Articles

Monsanto Submissions

Adriaens F, Bruneau P, deKerchove G, Hard DL. Evaluation of tailhead injection site swelling and sensitivity in British and French field trials (#89-168, # 90-001, #89-031, #90-110). Monsanto Submission 1990;
Reference ID: 5408

Adriaens F, Phipps RH, Weller RF, de KG, Hard DL, Hintz RL, Hartnell GF. Efficacy and safety of CP115099-F in dairy cows treated for a fourth consecutive lactation in the U.K. (#85-009D). Monsanto Submission 1991;
Reference ID: 5413

Arambel MJ, Lamb RC, Green GA, Madsen KS. Farm trials in Utah using bovine somatotropin (#87-066). Monsanto Submission 1989;
Reference ID: 5416

Bauman DE, Huber JT, Lamb RC, Samuels WA. Multi-location intramuscular single dose study (single dose IM) (#85-039, #85-038, #85-021, #86-003). Monsanto Submission 1987;
Reference ID: 7

Bussen SC, Collier RJ. Carcass evaluation study (#89-049). Monsanto Submission 1998;
Reference ID: 12

Cole WJ, Collier RJ, Eppard PJ, Hartnell GF, Hintz RL, Hoffman RG, Loesch TL, McLaughlin CL, McCrate MM, Selby BD, et al. Effect of Sometribove treatment of dairy cows on the incidence of clinical signs and birth abnormalities in the resulting offspring. Monsanto Submission 1992;
Reference ID: 5426

Collier RJ. Post-approval evaluation of Prosilac bovine somatotropin in commercial dairy herds (#93-051). Monsanto Submission 1996;
Reference ID: 5407

Collier RJ, McGrath MF. Injection site reaction field study (#91-072). Monsanto Submission 1998;
Reference ID: 9

DeLeon J.M., Eppard PJ, Lanza GM, Hammond BG, Cole WJ, Hudson S, Hintz RL, Miller MA, White TC, Metzger LE. Effect of CP115099-F treatment of the dam in study no.: 100-DDC-COW-PJE-85-010 on the subsequent health and reproductive performance of first generation heifers (86-024, 85-010). Monsanto Submission 1990;
Reference ID: 5423

Eppard PJ, Cole WJ. Multi-lactation chronic animal toxicity study (#85-010). Monsanto Submission 1990;
Reference ID: 4

Eppard PJ, Olsson PK, Cole WJ, Collier RJ, Hintz RL, McCrate MM, Selby BD, Sorbet RH, Veenhuizen J, Vicini JL. Effect of Sometribove treatment of the dam on health, growth, and reproduction of the resulting F1 Heifers (86-066). Monsanto Submission 1992;
Reference ID: 5424

Eppard PJ, Metzger LE, Hintz RL, Cole WJ, Collier RJ, McCrate MM, Olsson PK, Selby BD, Sorbet RH, Vicini JL, et al. Effect of bST treatment of the dam on health, growth and reproduction and milk production of the resulting F1 heifers (88-009). Monsanto Submission 1993;
Reference ID: 5425

Eppard PJ. Non-clinical injection site reaction study (#91-068). Monsanto Submission 1998;
Reference ID: 10

Erdman R, Samuels WA, Madsen KS. Farm trials in Maryland and Pennsylvania using bovine somatotropin (#88-063). Monsanto Submission 1989;
Reference ID: 5418

Franson SE, Cole WJ, Madsen KS, Hartnell GF, Hoffman RG, Meserole VK, Sprick DM, Dyes SE, Collier RJ, Hintz RL. Response of cows throughout lactation to Sometribove in a prolonged system - a dose titration study conducted at four U.S. sites (#87-023, #87-034, #87-029, #87-024). Monsanto Submission 1989;
Reference ID: 1

Galton DM, Samuels WA, Madsen KS. Farm trials in New York using bovine somatotropin (#87-067). Monsanto Submission 1989;
Reference ID: 5417

Gavert HO, Pabst K, Hard DL, Kerchove G, Madsen KS, Peel CJ, Wollny C. Safety and efficacy of CP115099-F. (Sometribove) in dairy cows through three consecutive lactations of treatment (#85-012A). Monsanto Submission 1989;
Reference ID: 5410

Huber JT, Bauman DE, Samuels WA, Lamb RC, Hard DL. Long term evaluation of zinc methionyl bovine somatotropin treatment in a prolonged release system for lactating multiparous cows at four U.S. clinical trial sites (85-039, 85-038, 85-021, 85-003. Monsanto Submission 1990;7(5)
Reference ID: 5422

Meserole VK, Duque JA, Hintz RL, Peel CJ. Evaluation of the galactopoietic response of bovine somatotropin (Sometribove (CP115099-F), 500mg and CP115400-P, 260mg) when administered subcutaneously to lactating Jersy cows in a commercial dairy herd (#89-075, #88-192). Monsanto Submission 1992;
Reference ID: 2

Messerole VK, Madsen KS, Hartnell GF, Cole WJ, Hintz RL, Samuels WA, Swenson GH. Response of cows to biweekly administration of sometribove (N-Methionyl Bovine Somatotropin) in a prolonged release system (CP115099-F) in commercial dairy herds in Michigan and New York (#87-065, #87-067). Monsanto Submission 1987;
Reference ID: 5415

Olson JD, Green GA, Madsen KS. Farm trials in Colorado using Somatotropin (#87-057). Monsanto Submission 1989;
Reference ID: 5414

Rijpkema YS, vanReeuwijk L, Hard DL. Responses of dairy cows to treatment with Sometribove (r-BST) during three consecutive years. Livestock Production Science 1990;26:193-216.
Reference ID: 5409

Schockmel LR, Vedeau F, Peel CJ, deKerchove G, Madsen KS, Hartnell GF. Efficacy and safety of CP115099-F in dairy cows. Report on lactations 1 and 2 of the French clinical trials performed at Sanders Experimental Centre, Saint Symphorien. (#85-16B). Monsanto Submission 1988;
Reference ID: 5411

Vicini JL, Eppard PJ, Lanza GM, Hudson S, Miller MA, Cole WJ, White TC, Nemeth MA, Abel KM, Duque JA, et al. Assessment of the effective range of CP115099-F in lactating primiparous and multiparous dairy cows (86-023). Monsanto Submission 1988;7(4)
Reference ID: 5421

Vicini JL, Hudson S, Cole WJ, Miller MA, Eppard PJ, White TC, Collier RJ. Effect of acute challenge with an extreme dose of somatotropin in a prolonged-release formulation on milk production and health of dairy cattle (#86-011). J.Dairy.Sci. 1990;73(8):2093-102.
Reference ID: 628

White TC, Collier RJ, Hartnell GF, Dyes SE, Hudson S, Miller MA, Metzger LE, Hintz RL, Sorbet RH, Curran TL, et al. Comparison of the effectiveness of intramuscular and subcutaneous administration of CP115099-F (#86-032). Monsanto Submission 1990;
Reference ID: 5

Key Articles

Arave CW, Anderson MJ, Walters JL. The influence of Sometribove dose and days in lactation on behavior of cows implanted with pelleted Sometribove. J.Dairy.Sci. 1994;77(11):3365-70.
Reference ID: 128

Barbano.D.M., Lynch JM, Bauman DE, Hartnell GF, Hintz RL, Nemeth MA. Effect of a prolonged-release formulation of N-methionyl bovine somatotropin (Sometribove) on milk composition. J.Dairy.Sci. 1992;75(7):1775-93.
Reference ID: 2215

Burton J.H., MacLeod G.K., McBride BW, Burton JL, Bateman K., McMillan I., Eggert RG. Overall efficacy of chronically administered recombinant bovine somatotropin to lactating dairy cows. J.Dairy.Sci. 1990;73(8):2157-67.
Reference ID: 627

Burton JL, McBride BW, Burton JH, Eggert RG. Health and reproductive performance of dairy cows treated for up to two consecutive lactations with bovine somatotropin. J.Dairy.Sci. 1990;73(11):3258-65.
Reference ID: 1218

Burton JL, McBride BW, Kennedy BW, Burton JH, Elsasser TH, Woodward B. Serum immunoglobulin profiles of dairy cows chronically treated with recombinant bovine somatotropin. J.Dairy.Sci. 1991;74(5):1589-98.
Reference ID: 410

Ceelen HJ. Bovine somatotropin and cow health--what are the facts? Can.vet.j. 1995;36(1):25-7.
Reference ID: 1018

Chalupa W, Vecchiarelli B, Galligan DT, Ferguson JD, Baird LS, Hemken RW, Harmon RJ, Soderholm CG, Otterby DE, Annexstad RJ, et al. Responses of dairy cows supplemented with somatotropin during weeks 5 through 43 of lactation. Journal.of.Dairy.Science 1996;5,800-5,812.
Reference ID: 5403

Cole WJ, Madsen KS, Hintz RL, Collier RJ. Effect of recombinantly-derived bovine somatotropin on reproductive performance of dairy cattle. Theriogenology 1991;36(4):573-95.
Reference ID: 961

Cole WJ, Eppard PJ, Boysen BG, Madsen KS, Sorbet RH, Miller MA, Hintz RL, White TC, Ribelin WE, Hammond BG, et al. Response of dairy cows to high doses of a sustained-release bovine somatotropin administered during two lactations. 2. Health and reproduction. J.Dairy.Sci. 1992;75(1):111-23.
Reference ID: 329

De La Sota RL, Lucy MC, Staples CR, Thatcher WW. Effects of recombinant bovine somatotropin (Sometribove) on ovarian function in lactating and nonlactating dairy cows. J.Dairy.Sci. 1993;76(4):1002-13.
Reference ID: 931

Elvinger F, Hansen PJ, Head HH, Natzke RP. Actions of bovine somatotropin on polymorphonuclear leukocytes and lymphocytes in cattle. J.Dairy.Sci. 1991;74(7):2145-52.
Reference ID: 3056

Eppard PJ, Hudson S, Cole WJ, Hintz RL, Hartnell GF, Hunter TW, Metzger LE, Torkelson AR, Hammond BG, Collier RJ, et al. Response of dairy cows to high doses of a sustained-release bovine somatotropin administered during two lactations. 1. Production response. J.Dairy.Sci. 1991;74(11):3807-21.
Reference ID: 1076

Eppard PJ, White TC, Sorbet RH, Weiser MG, Cole WJ, Hartnell GF, Hintz RL, Lanza GM, Vicini JL, Collier RJ. Effect of exogenous somatotropin on hematological variables of lactating cows and their offspring. J.Dairy.Sci. 1997;80(8):1582-91.
Reference ID: 1524

Esteban E, Kass PH, Weaver LD, Rowe JD, Holmberg CA, Franti CE, Troutt HF. Reproductive performance in high producing dairy cows treated with recombinant bovine somatotropin. J.Dairy.Sci. 1994;77(11):3371-81.
Reference ID: 127

Esteban E, Kass PH, Weaver LD, Rowe JD, Holmberg CA, Franti CE, Troutt HF. Pregnancy incidence in high producing dairy cows treated with recombinant bovine somatotropin. J.Dairy.Sci. 1994;77(2):468-81.
Reference ID: 157

Esteban E, Kass PH, Weaver LD, Rowe JD, Holmberg CA, Franti CE, Troutt HF. Interval from calving to conception in high producing dairy cows treated with recombinant bovine somatotropin. J.Dairy.Sci. 1994;77(9):2549-61.
Reference ID: 124

Gallo L, Cassandro M, Carnier P, Mantovani R, Ramanzin M, Bittante G, Tealdo E, Casson P. Modeling response to slow-releasing somatotropin administered at 3- or 4-week intervals. J.Dairy.Sci. 1994;77(3):759-69.
Reference ID: 160

Hansen WP, Otterby DE, Linn JG, Anderson JF, Eggert RG. Multi-farm use of bovine somatotropin for two consecutive lactations and its effects on lactational performance, health, and reproduction. J.Dairy.Sci. 1994;77(1):94-110.
Reference ID: 168

Hartnell GF, Franson SE, Bauman DE, Head HH, Huber JT, Lamb RC, Madsen KS, Cole WJ, Hintz RL. Evaluation of Sometribove in a prolonged-release system in lactating dairy cows - production responses. J.Dairy.Sci. 1991;74(8):2645-63.
Reference ID: 344

Hemken RW, Harmon RJ, Silvia WJ, Tucker WB, Heersche G, Eggert RG. Effect of dietary energy and previous bovine somatotropin on milk yield, mastitis, and reproduction in dairy cows. J.Dairy.Sci. 1991;74(12):4265-72.
Reference ID: 5135

Huber JT, Wu Z, Fontes C, Sullivan JL, Hoffman RG, Hartnell GF. Administration of recombinant bovine somatotropin to dairy cows for four consecutive lactations. J.Dairy.Sci. 1997;80(10):2355-60.
Reference ID: 34

Jenny BF, Grimes LW, Pardue FE, Rock DW, Patterson DL. Lactational response of Jersey cows to bovine somatotropin administered daily or in a sustained-release formulation. J.Dairy.Sci. 1992;75(12):3402-7.
Reference ID: 279

Jordan DC, Aguilar AA, Olson JD, Bailey C, Hartnell GF, Madsen KS. Effects of recombinant methionyl bovine somatotropin (Sometribove) in high producing cows milked three times daily. J.Dairy.Sci. 1991;74(1):220-6.
Reference ID: 425

Judge LJ, Erskine RJ, Bartlett PC. Recombinant bovine somatotropin and clinical mastitis: incidence, discarded milk following therapy, and culling. J.Dairy.Sci. 1997;80(12):3212-8.
Reference ID: 20

Kirby CJ, Smith MF, Keisler DH, Lucy MC. Follicular function in lactating dairy cows treated with sustained-release bovine somatotropin. J.Dairy.Sci. 1997;80(2):273-85.
Reference ID: 3295

Kirby CJ, Wilson SJ, Lucy MC. Response of dairy cows treated with bovine somatotropin to a luteolytic dose of prostaglandin F2 alpha. J.Dairy.Sci. 1997;80(2):286-94.
Reference ID: 539

Kronfeld DS. Health management of dairy herds treated with bovine somatotropin. J.Am.Vet.Med.Assoc. 1994;204(1):116-30.
Reference ID: 4744

Laurent F, Vignon B, Coomans D, Wilkinson J, Bonnel A. Influence of bovine somatotropin on the composition and manufacturing properties of milk. J.Dairy.Sci. 1992;75(8):2226-34.
Reference ID: 290

Lean IJ, Troutt HF, Bruss ML, Farver TB, Baldwin RL, Galland JC, Kratzer D, Holmberg CA, Weaver LD. Postparturient metabolic and production responses in cows previously exposed to long-term treatment with Somatotropin. J.Dairy.Sci. 1991;74(10):3429-45.
Reference ID: 385

Lean IJ, Bruss ML, Troutt HF, Galland JC, Farver TB, Rostami J, Holmberg CA, Weaver LD. Bovine ketosis and somatotrophin: risk factors for ketosis and effects of ketosis on health and production.
Bovine somatotropin (bST) and the dairy industry. Res.Vet.Sci. 1991;57(2):200-9.
Reference ID: 2104

Lean IJ, Baldwin RL, Troutt HF, Bruss ML, Galland JC, Farver TB, Rostami J, Weaver LD, Holmberg CA. Impact of bovine somatotropin administration beginning at day 70 of lactation on serum metabolites, milk constituents, and production in cows previously exposed to exogenous somatotropin. Am.J.Vet.Res. 1992;53(5):731-41.
Reference ID: 298

Leonard M, Gallo G, Gallo M, Block E. Effects of a 28-day sustained-release formulation of recombinant bovine somatotropin (rbST) administered to cows over two consecutive lactations. Can.J.Anim.Sci. 1990;70(3):795-809.
Reference ID: 5298

Lissemore KD, Leslie KE, McBride BW, Burton JH, Willan AR, Bateman KG. Observations on intramammary infection and somatic cell counts in cows treated with recombinant bovine somatotropin. Can.J.Vet.Res. 1991;55(2):196-8.
Reference ID: 406

Lynch JM, Barbano DM, Bauman DE, Hartnell GF, Nemeth MA. Effect of a prolonged-release formulation of N-methionyl bovine somatotropin (Sometribove) on milk fat. J.Dairy.Sci. 1992;75(7):1794-809.
Reference ID: 302

McBride BW, Burton JL, Gibson JP, Burton JH, Eggert RG. Use of recombinant bovine somatotropin for up to two consecutive lactations on dairy production traits. J.Dairy.Sci. 1990;73(11):3248-57.
Reference ID: 605

McClary DG, Green HB, Basson RP, Nickerson SC. The effects of a sustained-release recombinant bovine somatotropin (Somidobove) on udder health for a full lactation. J.Dairy.Sci. 1994;77(8):2261-71.
Reference ID: 136

Morbeck DE, Britt JH, McDaniel BT. Relationships among milk yield, metabolism, and reproductive performance of primiparous Holstein cows treated with Somatotropin. J.Dairy.Sci. 1991;74(7):2153-64.
Reference ID: 403

Nebel RL, McGilliard ML. Interactions of high milk yield and reproductive performance in dairy cows. J.Dairy.Sci. 1993;76(10):3257-68.
Reference ID: 215

Oldenbroek JK, Garssen GJ, Jonker LJ, Wilkinson JI. Effects of treatment of dairy cows with recombinant bovine somatotropin over three or four lactations. J.Dairy.Sci. 1993;76(2):453-67.
Reference ID: 249

Peel CJ, Sandles LD, Quelch KJ, Herington AC. The effects of long-term administration of bovine growth hormone on the lactational performance of identical-twin dairy cows. Anim.Prod. 1985;41(pt. 2):135-42.
Reference ID: 802

Pell AN, Tsang DS, Howlett BA, Huyler MT, Meserole VK, Samuels WA, Hartnell GF, Hintz RL. Effects of a prolonged-release formulation of Sometribove (n-methionyl bovine somatotropin) on Jersey cows. J.Dairy.Sci. 1992;75(12):3416-31.
Reference ID: 261

Phipps RH, Weller RF, Craven N, Peel CJ. Use of prolonged-release bovine somatotropin for milk production in British Friesian dairy cows. 1. Effect on intake, milk production and feed efficiency in two consecutive lactations of treatment. J.Agric.Sci. 1990;115(pt.1):95-104.
Reference ID: 645

Phipps RH, Bines V, Adriaens F. Use of prolonged-release bovine somatotropin for milk production in British Friesian dairy cows. 3. Effect on manufacturing properties and quality of Cheddar, Wensleydale and Cheshire cheese. J.Agric.Sci. 1990;115(pt.1):113-6.
Reference ID: 643

Rijpkema YS, vanReeuwijk L, Hard DL. Responses of dairy cows to treatment with Sometribove (r-BST) during three consecutive years. Livestock Production Science 1990;26:193-216.
Reference ID: 5409

Ruegg PL, Fabellar A, Hintz RL. Effect of the use of bovine somatotropin on culling practices in thirty-two dairy herds in Indiana, Michigan, and Ohio. Journal of Dairy Science 1998;81:1262-6.
Reference ID: 5419

Speicher JA, Tucker HA, Ashley RW, Stanisiewski EP, Boucher JF, Sniffen CJ. Production responses of cows to recombinantly derived bovine somatotropin and to frequency of milking. J.Dairy.Sci. 1994;77(9):2509-17.
Reference ID: 126

Stanisiewski EP, Krabill LF, Lauderdale JW. Milk yield, health, and reproduction of dairy cows given somatotropin (Somavubove) beginning early postpartum. J.Dairy.Sci. 1992;75(8):2149-64.
Reference ID: 291

Sullivan JL, Huber JT, DeNise SK, Hoffman RG, Kung L, Franson SE, Madsen KS. Factors affecting response of cows to biweekly injections of Sometribove. J.Dairy.Sci. 1992;75(3):756-63.
Reference ID: 318

Thomas JW, Erdman RA, Galton DM, Lamb RC, Arambel MJ, Olson JD, Madsen KS, Samuels WA, Peel CJ, Green GA. Responses by lactating cows in commercial dairy herds to recombinant bovine somatotropin. J.Dairy.Sci. 1991;74(3):945-64.
Reference ID: 416

Vicini JL, Hudson S, Cole WJ, Miller MA, Eppard PJ, White TC, Collier RJ. Effect of acute challenge with an extreme dose of somatotropin in a prolonged-release formulation on milk production and health of dairy cattle (#86-011). J.Dairy.Sci. 1990;73(8):2093-102.
Reference ID: 628

Waterman DF, Silvia WJ, Hemken RW, Heersche G, Swenson TS, Eggert RG. Effect of bovine somatotropin on reproductive function in lactating dairy cows. Theriogenology 1993;40(5):1015-28.
Reference ID: 1289

Weigel KA, Fisher TM, Van der Linde C, Gianola D, Rekaya R. Impact of bovine somatotropin on genetic evaluation of dairy sires and cows. Journal of Dairy Science 1998;81:2045-51.
Reference ID: 5428

Weller RF, Phipps RH, Craven N, Peel CJ. Use of prolonged-release bovine somatotropin for milk production in British Friesian dairy cows. 2. Effect on health and reproduction in two consecutive lactations of treatment. J.Agric.Sci. 1990;115(pt.1):105-12.
Reference ID: 644

Wells SJ, Trent AM, Collier RJ, Cole WJ. Effect of long-term administration of a prolonged release formulation of bovine somatotropin (Sometribove) on clinical lameness in dairy cows. Am.J.Vet.Res. 1995;56(8):992-6.
Reference ID: 1552

Whitaker DA, Smith EJ, Kelly JM, Hodgson-Jones LS. Health, welfare and fertility implications of the use of bovine somatotrophin in dairy cattle. Vet.Rec.J.Br.Vet.Assoc. 1988;122(21):503-5.
Reference ID: 730

White TC, Madsen KS, Hintz RL, Sorbet RH, Collier RJ, Hard DL, Hartnell GF, Samuels WA, de KG, Adriaens F, et al. Clinical mastitis in cows treated with Sometribove (recombinant bovine somatotropin) and its relationship to milk yield. J.Dairy.Sci. 1994;77(8):2249-60.
Reference ID: 137

Willeberg P. An international perspective on bovine somatotropin and clinical mastitis. J.Am.Vet.Med.Assoc. 1994;205(4):538-41.
Reference ID: 1029

Winsryg MD, Arambel MJ, Kent BA, Walters JL. Effect of Sometribove on rumen fermentation, rate of passage, digestibility, and milk production responses in dairy cows. J.Dairy.Sci. 1991;74(10):3518-23.
Reference ID: 384

Zhao X, Burton JH, McBride BW. Lactation, health, and reproduction of dairy cows receiving daily injectable or sustained-release somatotropin. J.Dairy.Sci. 1992;75(11):3122-30.
Reference ID: 281