Additional Substances for Consideration Post 2006

July 27, 2006

Results based on July 27, 2006 and persistent and bioaccumulative status as of July 2006

CAS RN	Chemical Name	Maximal List Group	Status	SimHaz Result Carcinogenicity1	SimHaz Result Developmental Toxicity2	SimHaz Result Genotoxicity3	SimHaz Result Reproductive Toxicity4
79-00-5	Ethane, 1,1,2-trichloro-	Post 2006	SimHaz Criteria Change	X
81-15-2	Benzene, 1-(1,1-dimethylethyl)-3,5-dimethyl-2,4,6-trinitro-	Post 2006	SimHaz Criteria Change	X
95-48-7	Phenol, 2-methyl-	Post 2006	SimHaz Criteria Change	X
100-00-5	Benzene, 1-chloro-4-nitro-	Post 2006	SimHaz Criteria Change	X		X
106-44-5	Phenol, 4-methyl-	Post 2006	SimHaz Criteria Change	X
106-94-5	Propane, 1-bromo-	Post 2006	SimHaz Criteria Change		X		X
108-39-4	Phenol, 3-methyl-	Post 2006	SimHaz Criteria Change	X
110-71-4	Ethane, 1,2-dimethoxy-	Post 2006	SimHaz Criteria Change		X		X
110-88-3	1,3,5-Trioxane	Post 2006	SimHaz Criteria Change		X
112-49-2	2,5,8,11-Tetraoxadodecane	Post 2006	SimHaz Criteria Change		X		X
115-10-6	Methane, oxybis-	Post 2006	PBITeco Change
126-13-6	α-D-Glucopyranoside, 6-O-acetyl-1,3,4-tris-O-(2-methyl-1-oxopropyl)-β-D-fructofuranosyl, 6-acetate 2,3,4-tris(2-methylpropanoate)	Post 2006	PBITeco Change
131-18-0	1,2-Benzenedicarboxylic acid, dipentyl ester	Post 2006	SimHaz Criteria Change		X		X
136-35-6	1-Triazene, 1,3-diphenyl-	Post 2006	SimHaz Criteria Change	X
156-43-4	Benzenamine, 4-ethoxy-	Post 2006	SimHaz Criteria Change			X
548-62-9	Methanaminium, N-[4-[bis[4-(dimethylamino)phenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, chloride	Post 2006	SimHaz Criteria Change	X
569-64-2	Methanaminium, N-[4-[[4-(dimethylamino)phenyl]phenylmethylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, chloride	Post 2006	SimHaz Criteria Change		X
600-14-6	2,3-Pentanedione	Post 2006	PBITeco Change
623-42-7	Butanoic acid, methyl ester	Post 2006	PBITeco Change
633-96-5	Benzenesulfonic acid, 4-[(2-hydroxy-1-naphthalenyl)azo]-, monosodium salt	Post 2006	PBITeco Change
915-67-3	2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-[(4-sulfo-1-naphthalenyl)azo]-, trisodium salt	Post 2006	PBITeco Change
1303-00-0	Gallium arsenide (GaAs)	Post 2006	SimHaz Criteria Change	X
1324-76-1	Benzenesulfonic acid, [[4-[[4-(phenylamino)phenyl][4-(phenylimino)-2,5-cyclohexadien-1-ylidene]methyl]phenyl]amino]-	Post 2006	PBITeco Change
1934-21-0	1H-Pyrazole-3-carboxylic acid, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]-, trisodium salt	Post 2006	PBITeco Change
2512-29-0	Butanamide, 2-[(4-methyl-2-nitrophenyl)azo]-3-oxo-N-phenyl-	Post 2007	PBITeco Change
2611-82-7	1,3-Naphthalenedisulfonic acid, 7-hydroxy-8-[(4-sulfo-1-naphthalenyl)azo]-, trisodium salt	Post 2006	PBITeco Change
5567-15-7	Butanamide, 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxo-	Post 2006	PBITeco Change
6417-83-0	2-Naphthalenecarboxylic acid, 3-hydroxy-4-[(1-sulfo-2-naphthalenyl)azo]-, calcium salt (1:1)	Post 2006	PBITeco Change
7023-61-2	2-Naphthalenecarboxylic acid, 4-[(5-chloro-4-methyl-2-sulfophenyl)azo]-3-hydroxy-, calcium salt (1:1)	Post 2006	PBITeco Change
7487-94-7	Mercury chloride (HgCl2)	Post 2006	SimHaz Criteria Change	X
15545-48-9	Urea, N'-(3-chloro-4-methylphenyl)-N,N-dimethyl-	Post 2006	SimHaz Criteria Change	X	X
17852-99-2	2-Naphthalenecarboxylic acid, 4-[(4-chloro-5-methyl-2-sulfophenyl)azo]-3-hydroxy-, calcium salt (1:1)	Post 2006	PBITeco Change
18015-76-4	Methanaminium, N-[4-[[4-(dimethylamino)phenyl]phenylmethylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, ethanedioate	Post 2006	SimHaz Criteria Change		X
38640-62-9	Naphthalene, bis(1-methylethyl)-	Post 2006	PBITeco Change
70146-13-3	Benzenesulfonic acid, oxybis[decyl-, disodium salt	Post 2006	PBITeco Change
84852-15-3	Phenol, 4-nonyl-, branched	Post 2006	SimHaz Criteria Change		X		X

¹ Carcinogenicity is determined by one or more of the following criteria:

European Community

• Category 1 (Known to be carcinogenic to humans)
• Category 2 (Regarded as if carcinogenic to humans)
• Category 3 (Causes concern for humans owing to possible carcinogenic effects)

Health Canada (Guidelines for Canadian Drinking Water Quality)

• Group I (Carcinogenic to humans)
• Group II (Probably carcinogenic to humans)
• Groups IIIA and IIIB (Possibly carcinogenic to humans)

International Agency for Research on Cancer

• Group 1 (Carcinogenic to humans)
• Group 2A (Probably carcinogenic to humans)
• Group 2B (Possibly carcinogenic to humans)

National Toxicology Program

• Known to be a human carcinogen
• Reasonably anticipated to be a human carcinogen

United States Environmental Protection Agency (US EPA) 1986 Carcinogenicity Guidelines

• Group A (Human carcinogen)
• Groups B1 and B2 (Probable human carcinogen)
• Group C (Possible human carcinogen)

US EPA 2003 Carcinogenicity Guidelines

• Carcinogenic to humans
• Likely to be carcinogenic to humans
• Suggestive evidence of carcinogenicity, but not sufficient to assess
• Human carcinogenic potential

² Developmental Toxicity is determined by one of the following criteria:

European Community

• Category 1 (Known to cause developmental toxicity in humans)
• Category 2 (Regarded as if they cause developmental toxicity in humans)
• Category 3 (Causes concern for humans owing to possible developmental toxic effects)

³ Genotoxicity is determined by one of the following criteria:

European Community

• Category 1 (Known to be mutagenic to humans)
• Category 2 (Regarded as if mutagenic to humans)
• Category 3 (Causes concern for humans owing to possible mutagenic effects)

⁴ Reproductive Toxicity is determined by one of the following criteria:

European Community

• Category 1 (Known to impair fertility in humans)
• Category 2 (Regarded as if they impair fertility in humans)
• Category 3 (Causes concern for human fertility)

CAS RN - Chemical Abstracts Registry Number
PBITeco - persistent and/or bioaccumulative and inherently toxic to non-human organisms
SimHaz - Simple Hazard Tool