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ARCHIVED - Draft "Maximal" List of Substances Prioritized by Health Canada for Consideration in Screening Assessment Under Cepa 1999

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Within seven years of the introduction of CEPA 1999 on September 14, 1999, the Ministers of Health and of the Environment are to complete categorization of the approximately 23,000 substances on the Domestic Substances List (DSL). The Minister of Health is identifying those substances on the DSL for subsequent screening assessment by both Departments that pose the greatest potential for exposure of the general population in Canada (GPE). The Minister of Health must also identify substances which are "inherently toxic" to humans (IThuman) for a subset of substances considered persistent (P) and/or bioaccumulative (B) by Environment Canada.

Based on this legislative construct, an approach has been developed to efficiently identify and prioritize substances that represent highest priorities from a human health perspective. (See companion document entitled: Proposed Integrated Framework for Health-Related Components of Categorization of Substances on the Domestic Substances List under CEPA 1999). This has required the development of transparent, scientifically defensible and discriminating "tools" for priority setting and subsequent screening assessment. (See companion document entitled: Tools for the Health-Related Components of DSL Categorization under CEPA 1999).

Based on application of the "tools" to date, a maximum of 1896 substances (i.e., the draft "maximal" list) has been identified that will be further considered in additional stages of prioritization for screening assessment (i.e., categorization). These substances have been identified on the basis of greatest potential for exposure of the general population in Canada (GPE) and "inherently toxic" to humans (IThuman), taking into account potential for persistence or bioaccumulation.

Health Canada is pleased to release this draft "maximal" list [HTML] - [EXCEL] at this time in an effort to focus the submission of solicited information on the identity, use and/or toxicity on any substance prioritized for further consideration. (See the companion document entitled: Invitation to Provide Information on Substances Being Considered in Priority Setting for Health-Related Components of the Categorization of the Domestic Substances List under CEPA 1999). The release of this draft "maximal" list provides sufficient time and opportunity for interested parties to submit data to justify reducing the number of substances on the final list to be considered by Health Canada for screening assessment under the Act.

Invitation to Provide Information on Substances Being Considered in Priority Setting for Health-Related Components of the Categorization of the Domestic Substances List under CEPA 1999

To assist stakeholders in focusing their efforts, this "maximal" list has been further divided into groups of substances with high, medium or low likelihood of remaining as human health related priorities for screening assessment post 2006. The 332 substances in the low priority group for screening assessment have been identified as low concern based on application of the " tools" to date or have been considered previously under CEPA. The draft "maximal" list includes substances present in products regulated under the Food and Drugs Act that were added to the DSL as listed in the Canada Gazette, Part II (Vol. 138, No. 3), February 11, 2004 that have been prioritized for further consideration.

Health Canada will continue to apply the "tools" to refine and finalize the list of health related priorities for screening assessment prior to the September, 2006 deadline for categorization mandated under CEPA 1999. Environment Canada decisions on persistence or bioaccumulation and "inherently toxic" to non-human organisms may have a minor impact on Health Canada's "maximal" list. It must also be emphasized that designation of substances in either a high, medium or low priority group is only provisional at this stage, and may change in subsequent steps as more complex tools are applied to refine further both estimates of exposure and identification of hazard.

Sub-lists of the "maximal" list of health-related priorities for further consideration in "categorization" and screening assessment

Health Canada is also releasing the following sub-lists to further focus attention relevant to submission of information.

The list entitled "Substances Which are Lowest Potential For Exposure and High Hazard" [HTML] - [EXCEL] includes 301 substances which have been identified as high hazard through weight of evidence determinations of other jurisdictions (i.e., by the simple hazard tool). They also fall within the group designated as "lowest potential for human exposure" (LPE) based on consideration by the simple exposure tool. As a result, they are priorities for further consideration in screening assessments. Health Canada is soliciting from industry, information or proposal(s) on the use and extent of current and/or potential options for risk management of substances in this group which would reduce their priority for further consideration in screening assessment.

The list entitled "Substances Which are Intermediate Potential for Exposure and Need PB Determinations" [HTML] - [EXCEL] includes 388 substances for which preliminary Persistence (P) and Bioaccumulation (B) determinations are not available. If these substances are determined to be neither P nor B, they would be moved to the "low likelihood" group of the maximal list and not considered priorities for screening assessment in 2006.