Referenced Tests & Lists

• Referenced Tests & Lists - Overview
• Tests & Lists Referenced in the CPR
• Status of Referenced Tests & Lists
• Sources of Referenced Tests & Lists

Referenced Tests & Lists - Overview:

Consistent with the spirit of the Government of Canada Regulatory Policy, internationally recognized lists, tests and standards have been referenced throughout the [WHMIS] Controlled Products Regulations (CPR). Due to regulatory process stipulations, the date of issue of the referenced documents was specified in the CPR.

Subsequent to the implementation of the CPR on October 31, 1988, a number of the referenced documents have been updated or replaced.

Tests & Lists Referenced In The CPR:

American Conference of Governmental Industrial Hygienists (ACGIH):

Threshold Limit Values and Biological Exposure Indices, published by the ACGIH, as amended from time to time; {CPR 54(a) and 58(a)}.

American Society for Testing and Materials (ASTM):

ASTM D56-82, Standard Test Method for Flash Point by Tag Closed Tester, dated August 27, 1982; {CPR Schedule IV, 1(a)}.

ASTM D93-80, Standard test Methods for Flash Point by Pensky-Martins Closed Tester, dated August 29, 1980; {CPR Schedule IV, 1(b)}.

ASTM D323-82, Standard Test Method for Vapor Pressure of Petroleum Products (Reid Method), dated August 27, 1982; {CPR 34(d)}

ASTM D445-83, Standard Test Method for Kinematic Viscosity of Transparent and Opaque Liquids (and the Calculation of Dynamic Viscosity), dated October 28, 1983; {CPR Schedule IV, 1(d)}

ASTM D3278-82, Standard Test Methods for Flash Point of Liquids by Setaflash Closed-Cup Apparatus, dated October 29, 1982; {CPR Schedule IV, 1(d)}.

ASTM D3828-81, Standard Test Methods for Flash Point by Setaflash Closed Tester, dated August 28, 1981; {CPR Schedule IV, 1(a) and (c)}.

Health Canada / Environment Canada:

Guidelines on the Use of Mutagenicity Tests in the Toxicological Evaluation of Chemicals, dated 1986, published under the authority of the Minister of National Health and Welfare and the Minister of the Environment; {CPR 57(2)(b), 58(a), 62(b) and 63}.

International Agency for Research on Cancer (IARC):

IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, published by the World Health Organization as amended from time to time; {CPR 54 and 58(a)}.

Journal of Pharmacology and Experimental Therapeutics:

Draize Test as described in Volume 82 of The Journal of Pharmacology and Experimental Therapeutics, dated 1944, pages 377 to 390; {CPR 33(3)(b)(ii)}.

National Association of Corrosion Engineers (NACE):

NACE Standard TM-01-69 (1976 Revision), Test Method, Laboratory Corrosion Testing of Metals for the Process Industries; {CPR 65 (a)}

Organization for Economic Cooperation and Development (OECD):

OECD Test Guideline No. 401, "Acute Oral Toxicity", dated May 12, 1981; {CPR 46(a), 48, 49(a) and 51}

OECD Test Guideline No. 402 "Acute Dermal Toxicity", dated May 12, 1981; {CPR 46(b), 48, 49(b) and 51}

OECD Test Guideline No. 403, "Acute Inhalation Toxicity", dated May 12, 1981; {CPR 46(c), (d), (e), 48, 49 (c), (d), 51 and 66(c)}.

OECD Test Guideline No. 404, "Acute Dermal Irritation/Corrosion", dated May 12, 1981; {CPR 60(a), 63, 65(b)}.

OECD Test Guideline No. 405, "Acute Eye Irritation/Corrosion", dated May 12, 1981; {CPR 60(b) and 63}.

OECD Test Guideline No. 406, "Skin Sensitization", dated May 12, 1981; {CPR 61(a) and 63}.

OECD Test Guideline No. 408 "Subchronic Oral Toxicity-Rodent: 90 day", dated May 12, 1981; {CPR 52(a)(i), 58(b), 59(a)(i) and 63}.

OECD Test Guideline No. 409 "Subchronic Oral Toxicity-Non Rodent: 90 day", dated May 12, 1981; {CPR 52(a)(ii), 58(b), 59(a)(ii) and 63}

OECD Test Guideline No. 411, "Subchronic Dermal Toxicity: 90 day" dated May 12, 1981; {CPR 52(b)(i), 58(b), 59(b)(i) and 63}.

OECD Test Guideline No. 413, "Subchronic Inhalation Toxicity: 90 day" dated May 12, 1981; {CPR 52(c)(i), 58(b), 59(c)(i)} and 63}.

OECD Test Guideline No. 414, "Teratogenicity" dated May 12, 1981; {CPR 53(1)(a) and 58(a)}.

OECD Test Guideline No. 415, "One Generation Reproduction Toxicity" dated May 26, 1983; {CPR 53(1)(b), 55(b)(i), and 58(a)}.

OECD Test Guideline No. 416, "Two Generation Reproduction Toxicity" dated May 26, 1983; {CPR 53(1)(c), 55(b)(ii), and 58}.

OECD Test Guideline No. 452, "Chronic Toxicity Studies" dated May 12, 1981; {CPR 52(a)(iii), 52(b)(ii), 52(c)(ii), 59(a)(iii), 59(b)(ii), 59(c)(ii) and 63}

Introduction to the OECD Guidelines on Genetic Toxicology Testing and Guidance on the Selection and Application of Assays", dated March 1, 1987, published in the Third Addendum to the OECD Guidelines for Testing of Chemicals; {CPR 57(2)(a), 58, 62(a) and 63}.

U.S. Federal Register:

"Proposed Guidelines for Registering Pesticides in the US; Hazard Evaluation, Human and Domestic Animals", published in Volume 43 of the US Federal Register (No. 163), dated 1978, on pages 37, 336-37, 403; {CPR 33(3)(b)(iv)}.

In the case of a 90 day test or chronic test, tests or methods described in US Food and Drug Administration (FDA) guidelines or the Environmental Protection Agency guidelines as published in the US Federal Register, as amended from time to time; {CPR 33(3)(b)(i)}.

World Health Organization:

Principles for the Testing of Drugs for Teratogenicity, Technical Report Series Number 364, published by the World Health Organization, 1967; {CPR 33(3)(b)(iii)}.

Status Of Referenced Tests & Lists:

American Conference of Governmental Industrial Hygienists (ACGIH):

In 1987, the ACGIH modified Appendix A of their referenced publication to eliminate the designations A1a and A1b and replace them by the designation A1. This modification also removed listings of carcinogens from Appendix A to the Table of Chemical Substances with Adopted TLVs.

The applicable portion of the ACGIH publication was modified again breaking what had been four groupings into five. In March 1996, the WHMIS Current Issues Committee agreed that CPR 54(a) be revised to include categories A1, A2 and A3.

American Society for Testing and Materials (ASTM):

ASTM D56-82 replaced by ASTM D56-00, Standard Test Method for Flash Point by Tag Closed Tester

ASTM D93-80 replaced by ASTM D93-00, Standard Test Methods for Flash Point by Pensky-Martens Closed Cup Tester

ASTM 323-82 replaced by ASTM 323-99a, Standard Test Method for Vapor Pressure of Petroleum Products (Reid Method)

ASTM D445-83 replaced by ASTM D445-97, Standard Test Method for Kinematic Viscosity of Transparent and Opaque Liquids (the Calculation of Dynamic Viscosity)

ASTM D3278-82 replaced by ASTM D3278-96e1, Standard Test Methods for Flash Point of Liquids by Small Scale Closed-Cup Apparatus

ASTM D3828-81 replaced by ASTM D3828-98, Standard Test Methods for Flash Point by Small Scale Closed Tester

National Association of Corrosion Engineers (NACE):

NACE Standard TM-01-69 (1976 Revision) replaced by NACE TM0169-2000, Item No. 21200 Standard Test Method, Laboratory Corrosion Testing of Metals

Organization for Economic Cooperation and Development (OECD):

OECD Test Guideline no. 401, "Acute Oral Toxicity"; updated guideline adopted February 24, 1987

OECD Test Guideline No. 402, "Acute Dermal Toxicity"; updated guideline adopted February 24, 1987

OECD Test Guideline No. 404, "Acute Dermal Irritation/Corrosion"; updated guideline adopted July 17, 1992

OECD Test Guideline No. 405, "Acute Eye Irritation/Corrosion"; updated guideline adopted February 24, 1987

OECD Test Guideline No 406, "Skin Sensitization"; updated guideline adopted July 17, 1992

OECD Test Guideline no. 408, "Repeated Dose 90-day Oral Toxicity in Rodents"; updated guideline adopted September 21, 1998

OECD Test Guideline No. 409, "Repeated Dose 90-day Oral Toxicity in Non-Rodents"; updated guideline adopted September 21, 1998

Sources Of Referenced Tests & Lists:

American Conference of Governmental Industrial Hygienists:

6500 Glenway Avenue, Building D-7
Cincinnati, Ohio
USA 45211
Tel: (513) 661-7881
http://www.acgih.org/

American Society for Testing and Materials:

1916 Race Street
Philadelphia, Pennsylvania
USA 19103
Tel: (215) 299-5400
http://www.astm.org

Health Canada:

Tunney's Pasture
Brooke Claxton Building
Publications
Ottawa, Ontario
KIN 0K9
Tel: (613) 954-5995; Fax: (613) 941-5366
http://www.hc-sc.gc.ca

International Agency for Research on Cancer:

Canadian Public Health Association
1565 Carling Avenue, Suite 400
Ottawa, Ontario, Canada
K1Z 8R1
Tel: (613) 725-3769;
e-mail: hrc@cpha.ca

or

IARC
150 Cours Albert Thomas
F-69372 Lyon, Cedex 03, France
http://www.iarc.fr/index.html

National Association of Corrosion Engineers:

PO Box 218340
Houston, Texas
USA 77218
Tel: (713) 492-0535
http://nace.org/nace/index.asp

Organization for Economic Cooperation and Development:

Renouf Publishing Co
PO Box 1008, Station B
61 Sparks Street
Ottawa, Ontario, Canada
K1P 5R1
Tel: (613) 745-2665;
e-mail: order@dept.renoufbooks.com

or

OECD Publications Service
2, rue André-Pascal
75775 Paris, Cedex 16, France
http://www.oecd.org/

U.S. Federal Register (U.S. Government Standards):

Superintendent of Documents
US Government Printing Office
Washington, DC
USA 20402
Tel: (202) 783-3238
http://www.access.gpo.gov/su_docs/aces/aces140.html