
ISBN: 978-1-100-18175-2
Cat. No.: H128-1/11-644E
HC Pub.: 110059
| Heat Exhaustion | Heat Stroke | |
|---|---|---|
| Temperature | Core temperature elevated but <40°C (104°F) | Core temperature ≥ 40°C (104°F) |
| Neurological |
|
Mental status changes:
|
| Cardiac |
|
|
| Skin |
|
|
| Other |
|
|
| Outcome | Untreated and with ongoing heat exposure, heat exhaustion can worsen and become heat stroke. |
In later stages, pulmonary edema, hepatic failure, renal failure, rhabdomyolysis (muscle fibre breakdown), death |
| Medication | Mechanism |
|---|---|
| Antiadrenergics and β-Blockers (e.g. Atenolol, Metoprolol) |
Can decrease cardiac output, and therefore shunting of warm blood from body core to periphery, limiting cooling. |
| Anticholinergics (e.g. Scopolamine) |
Can prevent sweat glands from functioning properly (i.e. inhibit rate of sweating and therefore rate of cooling). |
| Antidepressants (e.g. Prozac, Zoloft, other SSRIs) |
Many have anticholinergic properties (see above) and some can raise the brain's thermal set-point decreasing centrally induced thermoregulation. SSRIs can increase the risk of hyponatremia. |
| Antihistamines (e.g. Brompheniramine) |
Can inhibit the sweating mechanism. |
| Anti-Parkinson's agents (e.g. Benztropine, Levodopa, Trihexyphenidyl) |
Can inhibit the sweating mechanism. |
| Antipsychotics (e.g. Olanzapine) |
Can inhibit the sweating mechanism. Can induce a hyperthermic syndrome (neuroleptic malignant syndrome) on their own, which would be compounded by the effects of heat. |
| Sympathomimetics (e.g. Pseudoephedrine) |
Can prevent dilation of the blood vessels in the skin of the periphery (hands, feet, face) reducing the ability to dissipate heat by convection. |
| Diuretics (e.g. Lasix) |
Can lead to dehydration and hyponatremia is a common side effect. |
| Several drug classes (e.g. cholinesterase inhibitors, antiarrhythmics, calcium blockers) |
Can provoke diarrhea and/or vomiting, leading to dehydration. |
For additional information refer to Health Canada's Extreme Heat Events Guidelines: Technical Guide for Health Care Workers
For further information email: Climatinfo@hc-sc.gc.ca
For more information in your region: