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Priority Substances List Assessment Report- 1,3-Butadiene

4.0 References

• Adler, I.-D., J. Cao, J.G. Filser, P. Gassner, W. Kessler, U. Kliesch, A. Neuhauser-Klaus and M. Nusse. 1994. Mutagenicity of 1,3-butadiene inhalation in somatic and germinal cells of mice. Mutat. Res. 309: 307-314.
  
  
• Adler, I.-D., J.G. Filser, P. Gassner, W. Kessler, J. Schoneich and G. Schriever-Schwemmer. 1995a. Heritable translocations induced by inhalation exposure of male mice to 1,3- butadiene. Mutat. Res. 347: 121-127.
  
  
• Adler, I.D., U. Kliesch, C. Tiveron and R. Pacchierotti. 1995b. Clastogenicity of diepoxybutane in bone marrow cells and male germ cells in mice. Mutagenesis 10(6): 535-541.
  
  
• Adler, I.-D., U. Kliesch, L. Nylund and K. Peltonen. 1997. in vitro and in vivo mutagenicity of the butadiene metabolites butadiene diolepoxide, butadiene monoepoxide and diepoxybutane. Mutagenesis 12(5): 339-345.
  
  
• Adler, I.-D., J. Filser, H. Gonda and G. Schriever- Schwemmer. 1998. Dose response study for 1,3-butadiene-induced dominant lethal mutations and heritable translocations in germ cells of male mice. Mutat. Res. 397: 85-92.
  
  
• Albrecht, O.E., J.G. Filser and H.-G. Neumann. 1993. Biological monitoring of 1,3-butadiene: species differences in haemoglobin binding in rat and mouse. In: M. Sorsa, K. Peltonen, H. Vainio and K. Hemminki (eds.), Butadiene and styrene: Assessment of health hazards. International Agency for Research on Cancer, Lyon. pp. 135-142 (IARC Scientific Publications No. 127).
  
  
• Altshuller, A.P., W.A. Lonneman, F.D. Sutterfield and S.L. Kopezynski. 1971. Hydrocarbon composition of the atmosphere of the Los Angeles basin 1967. Environ. Sci. Technol. 5: 1009-1016.
  
  
• Anderson, D., A.J. Edwards and M.H. Brinkworth. 1993. Male-mediated F₁ effects in mice exposed to 1,3-butadiene. In: M. Sorsa, K. Peltonen, H. Vainio and K. Hemminki (eds.), Butadiene and styrene: Assessment of health hazards. International Agency for Research on Cancer, Lyon. pp. 171-181 (IARC Scientific Publications No. 127).
  
  
• Anderson, D., M.M. Dobrzynka, L.I. Jackson, T.-W. Yu and M.H. Brinkworth. 1997. Somatic and germ cell effects in rats and mice after treatment with 1,3-butadiene and its metabolites, 1,2-epoxybutene and 1,2,3,4-diepoxybutane. Mutat. Res. 391: 233-242.
  
  
• Anderson, D., J.A. Hughes, A.J. Edwards and M.H. Brinkworth. 1998. A comparison of male-mediated effects in rats and mice exposed to 1,3-butadiene. Mutat. Res. 397: 77-84.
  
  
• Andjelkovich, D., J. Taulbee and M. Symons. 1976. Mortality experience of a cohort of rubber workers, 1964-1973. J. Occup. Med. 18: 387-394.
  
  
• Andjelkovich, D., J. Taulbee, M. Symons and T. Williams. 1977. Mortality of rubber workers with reference to work experience. J. Occup. Med. 19: 397-405.
  
  
• Araki, A., T. Noguchi, F. Kato and T. Matsushima. 1994. Improved method for mutagenicity testing of gaseous compounds by using a gas sampling bag. Mutat. Res. 307: 335-344.
  
  
• Arce, G.T., D.R. Vincent, M.J. Cunningham, W.N. Choy and A.M. Sarrif. 1990. in vitro and in vivo genotoxicity of 1,3-butadiene and metabolites. Environ. Health Perspect. 86: 75-78.
  
  
• Atkinson, R., S.M. Aschmann, A.M. Winer and J.N. Pitts. 1984. Kinetics of the gas-phase reactions of NO3 radicals with a series of dialkenes, cycloalkenes, and monoterpenes at 291 K. Environ. Sci. Technol. 18: 370-375.
  
  
• Atkinson, R., J. Arey, S.M. Aschmann, W.D. Long, E.C. Tuazon and A.M. Winer. 1990. Lifetimes and fates of toxic air contaminants in California's atmosphere. Final report. California Air Resources Board, California Environmental Protection Agency. Statewide Air Pollution Research Center, University of California, Riverside, California, March (Contract No. A732-107).
  
  
• Au, W.W., W.E. Bechtold, E.B. Whorton, Jr. and M.S. Legator. 1995. Chromosome aberrations and response to γ-ray challenge in lymphocytes of workers exposed to 1,3- butadiene. Mutat. Res. 334: 125-130.
  
  
• Autio, K., L. Renzi, J. Catalan, O.E. Albrecht and M. Sorsa. 1994. Induction of micronuclei in peripheral blood and bone marrow erythrocytes of rats and mice exposed to 1,3-butadiene by inhalation. Mutat. Res. 309: 315-320.
  
  
• Barrefors, G. 1996. Air pollutants in road tunnels. Sci. Total Environ. 189/190: 431-435.
  
  
• Batinka, I.B. 1966. Maximum permissible concentrations of divinyl vapors in the air of work areas. Gig. Sanit. 31: 18-22.
  
  
• Bayer Inc. 1997. Personal communication from H. Michelin, Bayer Inc., Sarnia, Ontario, to Commercial Chemicals Evaluation Branch, Environment Canada, Hull, Quebec.
  
  
• Bechtold, W.E., M.R. Strunk, I.-Y. Chang, J.B. Ward, Jr. and R.F. Henderson. 1994. Species differences in urinary butadiene metabolites: comparisons of metabolite ratios between mice, rats, and humans. Toxicol. Appl. Pharmacol. 127: 44-49.
  
  
• Bechtold, W.E., M.R. Strunk, J.R. Thornton- Manning and R.F. Henderson. 1995. Analysis of butadiene, butadiene monoxide, and butadiene dioxide in blood by gas chromatography/mass spectrometry. Chem. Res. Toxicol. 8: 182-187.
  
  
• Bell, R.W., R.E. Chapman, B.D. Kruschel, M.J. Spencer, K.V. Smith and M.A. Lusis. 1991. The 1990 Toronto personal exposure pilot (PEP) study. Prepared for Atmospheric Research and Special Programs Section, Air Resources Branch, Ontario Ministry of the Environment, Toronto, Ontario (ARB-207-90).
  
  
• Bell, R.W., R.E. Chapman, B.D. Kruschel and M.J. Spencer. 1993. Windsor Air Quality Study. Personal Exposure Survey results. Science and Technology Branch, Ontario Ministry of Environment and Energy, Toronto, Ontario.
  
  Top of Page
  
  
  
• Bernardini, S., K. Pelin, K. Peltonen, H. Jarventaus, A. Hirvonen, C. Neagu, M. Sorsa and H. Norppa. 1996. Induction of sister chromatid exchange by 3,4- epoxybutane-1,2-diol in cultured human lymphocytes of different GSST1 and GSTM1 genotype. Mutat. Res. 361: 121-127.
  
  
• Bernardini, S., A. Hirvonen, K. Pelin and H. Norppa. 1998. Induction of sister chromatid exchange by 1,2-epoxy-3-butene in cultured human lymphocytes: influence of GSTT1 genotype. Carcinogenesis 19(2): 377-380.
  
  
• Bevan, C., J.C. Stadler, G.S. Elliott, S.R. Frame, J.K. Baldwin, H.-W. Leung, E. Moran and A.S. Panepinto. 1996. Subchronic toxicity of 4-vinylcyclohexene in rats and mice by inhalation exposure. Fundam. Appl. Toxicol. 32: 1-10.
  
  
• BIBRA International. 1996a. The detection of dominant lethal mutations and foetal malformations and chromosome damage in the offspring of male mice treated subchronically with butadiene by inhalation — second study. Carshalton, Surrey, U.K. (Report No. 1542/1).
  
  
• BIBRA International. 1996b. The detection of dominant lethal mutations and foetal malformations in the offspring of male rats treated sub-chronically with 1,3-butadiene by inhalation. Carshalton, Surrey, U.K. (Report No. 1542/2).
  
  
• Bol, J., H.J.M. Verhaar, C.J. van Leeuwen and J.L.M. Hermens. 1993. Predictions of the aquatic toxicity of high production-volumechemicals. Part B: Predictions. Ministerie van Volkshuisvesting, Ruimtelijke Ordening en Milieubeheer, The Hague, Netherlands (Report No. SVS 1993/9B).
  
  
• Bond, G.G., K.M. Bodner, G.W. Olsen and R.R. Cook. 1992. Mortality among workers engaged in the development or manufacture of styrene-based products — an update. Scand. J. Work Environ. Health 18: 145-154.
  
  
• Bond, J.A., A.R. Dahl, R.F. Henderson, J.S. Dutcher, J.L. Mauderly and L.S. Birnbaum. 1986. Species differences in the disposition of inhaled butadiene. Toxicol. Appl. Pharmacol. 84: 617-627.
  
  
• Boogaard, P.J. and J.A. Bond. 1996. The role of hydrolysis in the detoxification of 1,2:3,4-diepoxybutane by human, rat and mouse liver and lung in vitro . Toxicol. Appl. Pharmacol. 141: 617-627.
  
  
• Boogaard, P.J., S.C.-J. Sumner, M.J. Turner and J.A. Bond. 1996a. Hepatic and pulmonary glutathione conjugation of 1,2:3,4-diepoxybutane in human, rat, and mouse in vitro . Toxicology 113: 297-299.
  
  
• Boogaard, P.J., S.C.-J. Sumner and J.A. Bond. 1996b. Glutathione conjugation of 1,2:3,4-diepoxybutane in human liver and rat and mouse liver and lung in vitro . Toxicol. Appl. Pharmacol. 136: 307-316.
  
  
• Brinkworth, M.H., D. Anderson, J.A. Hughes, L.I. Jackson, T.-W. Yu and E. Hieschlag. 1998. Genetic effects of 1,3-butadiene on the mouse testis. Mutat. Res. 397: 67-75.
  
  
• Brunnemann, K.D., M.R. Dagan, J.E. Cox and D. Hoffmann. 1989. Determination of benzene, toluene and 1,3-butadiene in cigarette smoke by GC-MSD. Exp. Pathol. 37: 108-113.
  
  
• Bucher, J.R., R.L. Melnick and P.K. Hildebrandt. 1993. Lack of carcinogenicity in mice exposed once to high concentrations of 1,3-butadiene. J. Natl. Cancer Inst. 85(22): 1866-1867.
  
  
• Bunce, N. 1996. Atmospheric properties of substances on the Priority Substances List #2 (PSL2). Report to Environment Canada. University of Guelph, Guelph, Ontario.
  
  
• Camford Information Services. 1995. CPI product profiles. Don Mills, Ontario.
  
  
• Cao, X.-L. 1997. Method detection limits for 24 hour air samples from multimedia exposure pilot study. Personal communication from X.-L. Cao dated December 24, 1997, Health Canada (File No. MDL.XLS).
  
  
• CARB (California Air Resources Board). 1992. Technical support document. Proposed identification of 1,3-butadiene as a toxic air contaminant. State of California, Air Resources Board, Stationary Source Division.
  
  
• Carpenter, C.P., C.B. Shaffer, C.S. Weil and H.F. Smyth, Jr. 1944. Studies on the inhalation of 1:3-butadiene; with a comparison of its narcotic effect with benzol, toluol, and styrene, and a note on the elimination of styrene by the human. J. Ind. Hyg. Toxicol. 26: 69-78.
  
  
• Carter, W.P.L. 1994. Development of ozone reactivity scales for volatile organic compounds. Air Waste 44: 881-899.
  
  
• CEU (Commission of the European Union). 1995. Technical guidance document on environmental risk assessment for existing substances in the context of Commission regulation XX/94 in accordance with Council Regulation (EEC) No. 793/93 on the evaluation and control of existing substances. Chap. 3. Prepared by Chemicals Group of Umweltbundesamt, Berlin, under Contract B4-3040-93-663/AO. 82 pp.
  
  
• CEH-SRI International. 1994. Butadiene. Chemical Economics Handbook-SRI International (CEH Marketing Research Report).
  
  
• Checkoway, H. and T.M. Williams. 1982. A hematology survey of workers at a styrenebutadiene synthetic rubber manufacturing plant. Am. Ind. Hyg. Assoc. J. 43: 164-169.
  
  
• Choy, W.N., D.A. Vlachos, M.J. Cunningham, G.T. Arce and A.M. Sarrif. 1986. Genotoxicity of 1,3-butadiene. Induction of bone marrow micronuclei in B6C3F₁ mice and Sprague-Dawley rats in vivo. Environ. Mutagen. 8 (Suppl. 6): 18.
  
  
• Cochrane, J.E. and T.R. Skopek. 1993. Mutagenicity of 1,3-butadiene and its epoxide metabolites in human TK6 cells and in splenic T cells isolated from exposed B6C3F₁ mice. In: M. Sorsa, K. Peltonen, H. Vainio and K. Hemminki (eds.), Butadiene and styrene: Assessment of health hazards. International Agency for Research on Cancer, Lyon. pp. 195-204 (IARC Scientific Publications No. 127).
  
  Top of Page
  
  
  
• Cochrane, J.E. and T.R. Skopek. 1994a. Mutagenicity of butadiene and its epoxide metabolites: I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts. Carcinogenesis 15: 713-717.
  
  
• Cochrane, J.E. and T.R. Skopek. 1994b. Mutagenicity of butadiene and its epoxide metabolites: II. Mutational spectra of butadiene, 1,2-epoxybutene and diepoxybutane at the hprt locus in splenic T cells from exposed B6C3F₁ mice. Carcinogenesis 15: 719-723.
  
  
• Conner, M.K., J.E. Luo and O. Gutierrez de Gotera. 1983. Induction and rapid repair of sister-chromatid exchanges in multiple murine tissues in vivo by diepoxybutane. Mutat. Res. 108: 251-263.
  
  
• Conor Pacific Environmental. 1998. A report on multimedia exposures to selected PSL2 substances. Prepared by Conor Pacific Environmental (formerly Bovar Environmental) and Maxxam Analytics Inc. for Health Canada, Ottawa, Ontario (Project No. 741-6705; Contract # DSS File No. 025SS.H4078-6-C574).
  
  
• Cooper, R. 1989. Personal communication. Department of Biomedical and Environmental Health, School of Public Health, University of California, Berkeley, California [cited in CARB, 1992].
  
  
• Cowles, S.R., S.P. Tsai, P.J. Snyder and C.E. Ross. 1994. Mortality, morbidity, and haematological results from a cohort of long term workers involved in 1,3-butadiene monomer production. Occup. Environ. Med. 51: 323-329.
  
  
• CPPI (Canadian Petroleum Products Institute). 1997. Technical dossier - 1,3-Butadiene. Ottawa, Ontario.
  
  
• Crouch, C.N., D.H. Pullinger and I.F. Gaunt. 1979. Inhalation toxicity studies with 1,3-butadiene - 2. 3 month toxicity study in rats. Am. Ind. Hyg. Assoc. J. 40: 796-802.
  
  
• Crouch, C.N., D.H. Pullinger and I.F. Gaunt. 1979. Inhalation toxicity studies with 1,3-butadiene - 2. 3 month toxicity study in rats. Am. Ind. Hyg. Assoc. J. 40: 796-802.
  
  
• Csanády, G.A., F.P. Guengerich and J.A. Bond. 1992. Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats, and mice. Carcinogenesis 13: 1143-1153.
  
  
• Csanády, G.A., P.E. Kreuzer, C. Baur and J.G. Filser. 1996. A physiological toxicokinetic model for 1,3-butadiene in rodents and man: blood concentrations of 1,3-butadiene, its metabolically formed epoxides, and of haemoglobin adducts - relevance of glutathione depletion. Toxicology 113: 300-305.
  
  
• Cunningham, M.J., W.N. Choy, G.T. Arce, L.B. Rickard, D.A. Vlachos, L.A. Kinney and A.M. Sarrif. 1986. in vivo sister chromatid exchange and micronucleus induction studies with 1,3-butadiene in B6C3F₁ mice and Sprague-Dawley rats. Mutagenesis 6: 449-452.
  
  
• Dann, T. 1997. Unpublished data on 1,3-butadiene levels in Canada from NAPS program, provided to Commercial Chemicals Evaluation Branch, Environment Canada, Hull, Quebec. Environment Canada, River Road Environmental Technology Centre, Ottawa, Ontario, April 1997.
  
  
• Dann, T. and P. Summers. 1997. Canadian 1996 NO_x/VOC science assessment - Groundlevel ozone and its precursors, 1980-1993. Report of the Data Analysis Working Group, Multi-stakeholder NO_x/VOC Science Program.
  
  
• Darnell, K.R., A.C. Lloyd, A.M. Winer and J.N. Pitts, Jr. 1976. Reactivity scale for atmospheric hydrocarbons based on reaction with hydroxyl radical. Environ. Sci. Technol. 10: 692-696.
  
  Top of Page
  
  
  
• Daugherty, F.M., Jr. and J.T. Garrett. 1951. Toxicity level of hydrocyanic acid and some industrial by-products. Tex. J. Sci. 3: 391-396.
  
  
• Davis, B. 1998. Personal communication. Electronic correspondence dated June 26, 1998. National Institute for Environmental Health and Safety, National Toxicology Program, Research Triangle Park, North Carolina.
  
  
• Delzell, E., N. Sathiakumar, M. Macaluso, M. Hovinga, R. Larson, F. Barone, C. Beall, P. Cole, J. Julian and D.C.F. Muir. 1995. A follow-up study of synthetic rubber workers. Prepared for the International Institute of Synthetic Rubber Workers, October 2, 1995.
  
  
• Delzell, E., M. Macaluso, C. Lally and P. Cole. 1996. Mortality study of synthetic rubber workers: additional analyses of data on monomer peaks and employment in certain work areas. Prepared for the International Institute of Synthetic Rubber Workers, October 16, 1996.
  
  
• de Meester, C., F. Poncelet, M. Roberfroid and M. Mercier. 1978. Mutagenicity of butadiene and butadiene monoxide. Biochem. Biophys. Res. Commun. 80: 298 [cited in de Meester et al., 1980].
  
  
• de Meester, C., F. Poncelet, M. Roberfroid and M. Mercier. 1980. The mutagenicity of butadiene towards Salmonella typhimurium. Toxicol. Lett. 6: 125-130.
  
  
• Deutschmann, S. and R.J. Laib. 1989. Concentration-dependent depletion of nonprotein sulfhydryl (NPSH) content in lung, heart and liver tissue of rats and mice after acute inhalation exposure to butadiene. Toxicol. Lett. 45: 175-183.
  
  
• Divine, B.J. and C.M. Hartman. 1996. Mortality update of butadiene production workers. Toxicology 113: 169-181.
  
  
• Divine, B.J., J.K. Wendt and C.M. Hartman. 1993. Cancer mortality among workers at a butadiene production facility. In: M. Sorsa, K. Peltonen, H. Vainio and K. Hemminki (eds.), Butadiene and styrene: Assessment of health hazards. International Agency for Research on Cancer, Lyon. pp. 345-362 (IARC Scientific Publications No. 127).
  
  
• Doerr, J.K., S.B. Hooser, B.J. Smith and I.G. Sipes. 1995. Ovarian toxicity of 4-vinylcyclohexene and related olefins in B6C3F₁ mice: role of diepoxides. Chem. Res. Toxicol. 8: 963-969.
  
  
• Doerr, J.K., E.A. Hollis and I.G. Sipes. 1996. Species difference in the ovarian toxicity of 1,3-butadiene epoxides in B6C3F₁ mice and Sprague-Dawley rats. Toxicology 113: 128-136.
  
  
• Downs, T., S. Pier, M. Crane, K. Yim and K. Kim. 1993. Cause-specific mortality in a cohort of 1000 ABS workers. In: International Symposium on Health Hazards of Butadiene and Styrene - Abstracts. April 18-21, 1993, Espoo, Finland. p. 72.
  
  
• Duescher, R.J. and A.A. Elfarra. 1992. 1,3- Butadiene oxidation by human myeloperoxidase. Role of chloride ion in catalysis of divergent pathways. J. Biol. Chem. 267(28): 19 859-19 865.
  
  
• Duescher, R.J. and A.A. Elfarra. 1994. Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: evidence for major roles by cytochromes P450 2A6 and 2E1. Arch. Biochem. Biophys. 311(2): 342-349.
  
  
• Duffy, B.L. and P.F. Nelson. 1996. Non-methane exhaust composition in the Sydney Harbour tunnel: a focus on benzene and 1,3-butadiene. Atmos. Environ. 30(15): 2759-2768.
  
  Top of Page
  
  
  
• Eisenreich, S.J., B.B. Looney and J.D. Thornton. 1981. Airborne organic contaminants in the Great Lakes ecosystem. Environ. Sci. Technol. 15: 30-38.
  
  
• Elfarra, A.A., R.J. Krause and R.R. Selzer. 1996. Biochemistry of 1,3-butadiene metabolism and its relevance to 1,3-butadiene-induced carcinogenicity. Toxicology 113: 23-30.
  
  
• Environment Canada. 1994. Underground garage air quality assessment program. Prepared by L. Graham, D. Rosenblatt and P. Barton, Technology Development Directorate, Environment Canada, for S. Lamy, Environmental Health Directorate, Health Canada, Ottawa (MSED Report #94-29).
  
  
• Environment Canada. 1996a. Personal communication from L.A. Graham, River Road Environmental Technology Centre, Environment Canada, Ottawa, Ontario, to Commercial Chemicals Evaluation Branch, Environment Canada, Hull, Quebec.
  
  
• Environment Canada. 1996b. Summary report - 1994. National Pollutant Release Inventory (NPRI), Pollution Data Branch, Hull, Quebec.
  
  
• Environment Canada. 1996c. National Analysis of Trends in Emergencies System (NATES) Database. Environmental Emergencies Branch, Hull, Quebec.
  
  
• Environment Canada. 1997a. Environmental assessments of Priority Substances under the Canadian Environmental Protection Act. Guidance manual version 1.0 - March 1997. Chemicals Evaluation Division, Commercial Chemicals Evaluation Branch, Hull, Quebec (Environmental Protection Series EPS/2/CC/3E).
  
  
• Environment Canada. 1997b. Notice respecting the second Priority Substances List and di(2-ethylhexyl) phthalate. Canada Gazette, Part I, February 15, 1997. pp. 366-368.
  
  
• Environment Canada. 1997c. Results of the CEPA Section 16 Notice respecting the second Priority Substances List and di(2-ethylhexyl) phthalate. Use Patterns Section, Commercial Chemicals Evaluation Branch, Hull, Quebec.
  
  
• Environment Canada. 1997d. Summary report - 1995. National Pollutant Release Inventory (NPRI), Pollution Data Branch, Hull, Quebec.
  
  
• Environment Canada. 1998. Canadian Environmental Protection Act - Priority Substances List - Supporting document for the environmental assessment of 1,3-butadiene. Commercial Chemicals Evaluation Branch, Hull, Quebec.
  
  
• Environment Canada and Health Canada. 1999. Notice concerning the assessment of the Priority Substance 1,3-butadiene. Canada Gazette, Part I, October 2, 1999. pp. 2821-2823.
  
  
• Epicure. 1993. Epicure: Risk regression and data analysis software. HiroSoft International Corporation, Seattle, Washington.
  
  
• Galassi, S. and M. Vighi. 1981. Testing toxicity of volatile substances with algae. Chemosphere 10: 1123-1126.
  
  
• Gerin, M. and J. Siemiatycki. 1998. An evaluation of the exposure assessment methods developed at the University of Alabama for the study of cancer among synthetic rubber workers. Prepared for Priority Substances Program, Health Canada, Ottawa, Ontario.
  
  Top of Page
  
  
  
• Hackett, P.L., M.R. Sikov, T.J. Mast, M.G. Brown, R.L. Buschbom, M.L. Clark, J.R. Decker, J.J. Evanoff, R.L. Rommereim, S.E. Rowe and R.B. Westerberg. 1987a. Inhalation developmental toxicology studies of 1,3-butadiene in the rat. Pacific Northwest Laboratory, Richland, Washington (Report No. PNL-6414/UC-48) [cited in Morrissey et al., 1990].
  
  
• Hackett, P.L., M.R. Sikov, T.J. Mast, M.G. Brown, R.L. Buschbom, M.L. Clark, J.R. Decker, J.J. Evanoff, R.L. Rommereim, S.E. Rowe and R.B. Westerberg. 1987b. Inhalation developmental toxicology studies: teratology study of 1,3-butadiene in mice. Pacific Northwest Laboratory, Richland, Washington (Report No. PNL-6412/UC-48) [cited in Morrissey et al., 1990].
  
  
• Hallberg, L.M., W.E. Bechtold, J. Grady, M.S. Legator and W.W. Au. 1997. Abnormal DNA repair activities in lymphocytes of workers exposed to 1,3-butadiene. Mutat. Res. 383: 213-221.
  
  
• Hamilton-Wentworth. 1997. Human health risk assessment for priority air pollutants. Hamilton-Wentworth Air Quality Initiative. December 1997.
  
  
• Hayes, R.B., L. Xi, W.E. Bechtold, N. Rothman, M. Yao, R. Henderson, L. Zhang, M.T. Smith, D. Zhang, J. Wiemels, M. Dosemeci, S. Yin and J.P. O'Neill. 1996. hprt mutation frequency among workers exposed to 1,3-butadiene in China. Toxicology 113: 100-105.
  
  
• Hazleton Laboratories Europe Ltd. 1981a. The toxicity and carcinogenicity of butadiene gas administered to rats by inhalation for approximately 24 months. Final report. Prepared by P.E. Owen (Report No. 2653-522/2).
  
  
• Hazleton Laboratories Europe Ltd. 1981b. 1,3-Butadiene: Inhalation teratogenicity study in the rat. Final report. Prepared by L.F.H. Irvine (Report No. 2788-522/3).
  
  
• Hazleton Laboratories Europe Ltd. 1982. 1,3-Butadiene: Inhalation teratogenicity study in the rat. Addendum to final report. Prepared by L.F.H. Irvine (Report No. 2788-522/3).
  
  
• Health Canada. 1994. Canadian Environmental Protection Act - Human health risk assessment for Priority Substances. Ottawa, Ontario.
  
  
• Heck, W.W. and G. Pires. 1962. Growth of plants fumigated with saturated and unsaturated gases and their derivatives. Tex. Agric. Exp. Stn. Misc. Publ. MP-603. 12 pp.
  
  
• Henderson, R.F., W.E. Bechtold, P.J. Sabourin, K.R. Maples and A.R. Dahl. 1993. Species differences in the metabolism of 1,3-butadiene in vivo. In: M. Sorsa, K. Peltonen, H. Vainio and K. Hemminki (eds.), Butadiene and styrene: Assessment of health hazards. International Agency for Research on Cancer, Lyon. pp. 57-64 (IARC Scientific Publications No. 127).
  
  
• Henderson, R.F., J.R. Thornton-Manning, W.E. Bechtold and A.R. Dahl. 1996. Metabolism of 1,3-butadiene: species differences. Toxicology 113: 17-22.
  
  
• Hermens, J., H. Canton, P. Janssen and R. de Jong. 1984. Quantitative structure- activity relationships and toxicity studies of mixtures of chemicals with an anaesthetic potency: acute lethal and sublethal toxicity to Daphnia magna. Aquat. Toxicol. 5: 143-154.
  
  
• Himmelstein, M.W., M.J. Turner, B. Asgharian and J.A. Bond. 1994. Comparison of blood concentrations of 1,3-butadiene and butadiene epoxides in mice and rats exposed to 1,3- butadiene by inhalation. Carcinogenesis 15(8): 1479-1486.
  
  
• Himmelstein, M.W., B. Asgharian and J.A. Bond. 1995. High concentrations of butadiene epoxides in livers and lungs of mice compared to rats exposed to 1,3-butadiene. Toxicol. Appl. Pharmacol. 132: 281-288.
  
  Top of Page
  
  
  
• Himmelstein, M.W., J.F. Acquavella, L. Recio, M.A. Medinsky and J.A. Bond. 1997. Toxicology and epidemiology of 1,3- butadiene. Crit. Rev. Toxicol. 27(1): 1-108.
  
  
• Howard, P.H. 1990. Handbook of environmental fate and exposure data for organic chemicals. Vol. 1. Lewis Publishers Inc., Chelsea, Michigan. pp. 101-106.
  
  
• Howard, P.H., R.S. Boethling, W.F. Jarvis, W.M. Meylan and E.M. Michalenko. 1991. Handbook of environmental degradation rates. Lewis Publishers Inc., Chelsea, Michigan.
  
  
• Howe, R.B. 1995a. THC: A computer program to compute a reference dose from continuous animal toxicity data using the benchmark dose method. ICF Kaiser Engineers, Inc., Ruston, Louisiana.
  
  
• Howe, R.B. 1995b. THRESH: A computer program to compute a reference dose from quantal animal toxicity data using the benchmark dose method. ICF Kaiser Engineers, Inc., Ruston, Louisiana.
  
  
• Howe R.B. and K.S. Crump. 1982. Global82: A computer program to extrapolate quantal animal toxicity data to low doses. Science Research Systems, Ruston, Louisiana.
  
  
• IARC (International Agency for Research on Cancer). 1992. Occupational exposures to mists and vapours from strong inorganic acids; and other industrial chemicals. International Agency for Research on Cancer, Lyon (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 54).
  
  
• Irons, R.D. 1998. Personal communication to Health Canada. Correspondence dated March 30, 1998. University of Colorado Health Sciences Center, Denver, Colorado.
  
  
• Irons, R.D. and D.W. Pyatt. 1998. Dithiocarbamates as potential confounders in butadiene epidemiology. Carcinogenesis 49(4): 539-542.
  
  
• Irons, R.D., C.N. Smith, W.S. Stillman, R.S. Shah, W.H. Steinhagen and L.J. Leiderman. 1986a. Macrocyticmegaloblastic anemia in male B6C3F₁ mice following chronic exposure to 1,3-butadiene. Toxicol. Appl. Pharmacol. 83: 95-100.
  
  
• Irons, R.D., C.N. Smith,W.S. Stillman, R.S. Shah, W.H. Steinhagen and L.J. Leiderman. 1986b. Macrocytic-megaloblastic anemia in male NIH Swiss mice following repeated exposure to 1,3-butadiene. Toxicol. Appl. Pharmacol. 85: 450-455.
  
  
• Irons, R.D., M. Oshimura and J.C. Barrett. 1987. Chromosome aberrations in mouse bone marrow cells following in vivo exposure to 1,3-butadiene. Carcinogenesis 8: 1711-1714.
  
  
• Irons, R.D., H.P. Cathro, W.S. Stillman, W.H. Steinhagen and R.S. Shah. 1989. Susceptibility to 1,3-butadiene-induced leukemogenesis correlates with endogenous ecotropic retroviral background in the mouse. Toxicol. Appl. Pharmacol. 101: 170-176.
  
  
• Irons, R.D., A.T. Le, D.B. Som and W.S. Stillman. 1995. 2'3'-Dideoxycytidine-induced thymic lymphoma correlates with species-specific suppression of a subpopulation of primitive hematopoietic progenitor cells in mouse but not rat or human bone marrow. J. Clin. Invest. 95: 2777-2782.
  
  
• Irons, R.D., D.B. Colagiovanni and W.S. Stillman. 1996. Murine thymic lymphoma is associated with a species-specific hematopoietic progenitor cell subpopulation. Toxicology 113: 59-67.
  
  Top of Page
  
  
  
• IUCLID. 1996. European Commission International Uniform Chemical Information Database.
  
  
• Jaber, H.M., W.R. Mabey, A.T. Liu, T.W. Chou and H.L. Johnson. 1984. Data acquisition for environmental transport and fate screening. SRI International, Menlo Park, California (EPA 600/6-84-009).
  
  
• Jauhar, P.P., P.R. Henika, J.T. MacGregor, C.M. Wehr, M.D. Shelby, S.A. Murphy and B.H. Margolin. 1988. 1,3-Butadiene: induction of micronucleated erythrocytes in the peripheral blood of B6C3F₁ mice exposed by inhalation for 13 weeks. Mutat. Res. 209: 171-176.
  
  
• Jelitto, B., R.R. Vangala and R.J. Laib. 1989. Species differences in DNA damage by butadiene: Role of diepoxybutane. Arch. Toxicol., Suppl. 13: 246-249.
  
  
• Kelsey, K.T., J.K. Wiencke, J. Ward, W. Bechtold and J. Fajen. 1995. Sister-chromatid exchanges, glutathione S-transferase è deletion and cytogenetic sensitivity to diepoxybutane in lymphocytes from butadiene monomer production workers. Mutat. Res. 335: 267-273.
  
  
• Kenaga, E.E. 1980. Predicted bioconcentration factors and soil sorption coefficients of pesticides and other chemicals. Ecotoxicol. Environ. Saf. 4: 26-38.
  
  
• Koivisto, P., M. Sorsa, F. Pacchierotti and K. Peltonen. 1997. ³²P-postlabelling/HPLC assay reveals an enantioselective adduct formation in N7 guanine residues in vivo after 1,3-butadiene inhalation exposure. Carcinogenesis 18(2): 439-443.
  
  
• Koivisto, P., I.-D. Adler, F. Pacchierotti and K. Peltonen. 1998. DNA adducts in mouse testes and lung after inhalation exposure to 1,3-butadiene. Mutat. Res. 397: 3-10.
  
  
• Krause R.J. and A.A. Elfarra. 1997. Oxidation of butadiene monoxide to meso- and (±)- diepoxybutane by cDNA-expressed human cytochrome P450s and by mouse, rat, and human liver microsomes: evidence for preferential hydration of meso-diepoxybutane in rat and human liver microsomes. Arch. Biochem. Biophys. 337(2): 176-184.
  
  
• Krause, R.J., J.E. Sharer and A.A. Elfarra. 1997. Epoxide hydrolase-dependent metabolism of butadiene monoxide to 3-butene-1,2-diol in mouse, rat, and human liver. Drug Metab. Dispos. 25(8): 1013-1015.
  
  
• Kreiling, R., R.J. Laib and H.M. Bolt. 1986b. Alkylation of nuclear proteins and DNA after exposure of rats and mice to [1,4-¹⁴C]1,3-butadiene. Toxicol. Lett. 30: 131-136.
  
  
• Kreuzer, P.E., W. Kessler, H.F. Welter, C. Baur and J.G. Filser. 1991. Enzyme specific kinetics of 1,2-epoxybutene-3 in microsomes and cytosol from livers of mouse, rat, and man. Arch. Toxicol. 65: 59-67.
  
  
• Labstat, Inc. 1995. An assessment of the chemical toxicity of the smoke from Canadian cigarettes: Method development and analytical results for ammonia, pyridine, 1-3 butadienne (sic) and vinyl chloride. Final report. November 30, 1995. Determined under contract with Health Canada (H1021-4-9127/02-SS).
  
  
• Lähdetie, J. and J. Grawé. 1997. Flow cytometric analysis of micronucleus induction in rat bone marrow polychromatic erythrocytes by 1,2:3,4-diepoxybutane, 3,4-epoxy-1-butene, and 1,2-epoxybutane-3,4-diol. Cytometry 28: 228-235.
  
  
• Lähdetie, J., K. Peltonen and T. Sjoblöm. 1997. Germ cell mutagenicity of three metabolites of 1,3-butadiene in the rat: induction of spermatid micronuclei by butadiene mono-, di-, and diolepoxides in vivo. Environ. Mol. Mutagen. 29: 230-239.
  
  Top of Page
  
  
  
• Landi, S., I. Ponzanelli, A. Hirvonen, H. Norppa and R. Barale. 1996. Repeated analysis of sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes: effect of glutathione S-transferase T1 and M1 genotype. Mutat. Res. 351: 79-85.
  
  
• Leavens, T.L., G.M. Farris, R.A. James, R. Shah, V.A. Wong, M.W. Marshall and J.A. Bond. 1997. Genotoxicity and cytotoxicity in male B6C3F₁ mice following exposure to mixtures of 1,3-butadiene and styrene. Environ. Mol. Mutagen. 29: 335-345.
  
  
• Legator, M.S., W.W. Au, M. Ammenheuser and J.B. Ward, Jr. 1993. Elevated somatic cell mutant frequencies and altered DNA repair responses in nonsmoking workers exposed to 1,3-butadiene. In: M. Sorsa, K. Peltonen, H. Vainio and K. Hemminki (eds.), Butadiene and styrene: Assessment of health hazards. International Agency for Research on Cancer, Lyon. pp. 253-263 (IARC Scientific Publications No. 127).
  
  
• Leiderman, L.J., W.S. Stillman, R.S. Shah, W.H. Steinhagen and R.D. Irons. 1986. Altered hematopoietic stem cell development in male B6C3F₁ mice following exposure to 1,3-butadiene. Exp. Mol. Pathol. 44: 50-56.
  
  
• Leo, A., P.Y.C. Jow, C. Silipo and C. Hansch. 1975. Calculation of hydrophobic constant (log P) from constants. J. Med. Chem. 18: 865-868.
  
  
• Ligocki, M.P., J.L. Fieber, J.C. Ball, S.A. Pezda, J.M. Heuss, R.T. Paul and H.J. Wimette. 1994. Sources, projected emission trends and exposure issues for 1,3-butadiene. Presentation at the 87th Annual Meeting and Exhibition of the Air and Waste Management Association, Cincinnati, Ohio, June.
  
  
• Linet, M.S., W. Stewart, M.L. Van Natta, L.D. McCaffrey and M. Szklo. 1987. Comparison of methods for determining occupational exposure in a case-control interview study of chronic lymphocytic leukemia. J. Occup. Med. 29(2): 136-141.
  
  
• Lyman, W.J., W.F. Reehl and D.H. Rosenblatt. 1982. Handbook of chemical property estimation methods. McGraw-Hill Book Co., New York, N.Y.
  
  
• Lynch, J. 1998. Personal communication with Health Canada. Correspondence dated March 20, 1998. Consultant, Rumson, New Jersey.
  
  
• Mabon, N., B. Moorthy, E. Randerath and K. Randerath. 1996. Monophosphate ³²P-postlabeling assay of DNA adducts from 1,2:3,4-diepoxybutane, the most genotoxic metabolite of 1,3-butadiene: in vitro methodological studies and in vivo dosimetry. Mutat. Res. 371: 87-104.
  
  
• Macaluso, M., E. Delzell, M. Sanders and R. Larson. 1997. Historical estimation of exposure to butadiene and styrene among synthetic rubber workers. Prepared for the International Institute of Synthetic Rubber Workers, August 22, 1997.
  
  
• Mackay, D. 1991. Multimedia environmental models: the fugacity approach. Lewis Publishers Inc., Chelsea, Michigan.
  
  
• Mackay, D. and S. Paterson. 1991. Evaluating the multimedia fate of organic chemicals: a Level III fugacity model. Environ. Sci. Technol. 25: 427.
  
  
• Mackay, D. and W.Y. Shiu. 1981. A critical review of Henry's law constants for chemicals of environmental interest. J. Phys. Chem. Ref. Data 10: 1175-1199.
  
  
• Mackay, D., W.Y. Shiu and K.C. Ma. 1993. Illustrated handbook of physical-chemical properties and environmental fate of organic compounds. Vol. III. Lewis Publishers Inc., Chelsea, Michigan.
  
  Top of Page
  
  
  
• Maniglier-Poulet, C., X. Cheng, J.A. Ruth and D. Ross. 1995. Metabolism of 1,3-butadiene monoxide in mouse and human bone marrow cells. Chem.-Biol. Interact. 97: 119-129.
  
  
• Matanoski, G.M., C. Santos-Burgoa and L. Schwartz. 1990. Mortality of a cohort or workers in the styrene-butadiene polymer manufacturing industry (1943-1982). Environ. Health Perspect. 86: 107-117.
  
  
• Matanoski, G., M. Francis, A. Correa-Villaseñor, E. Elliott, C. Santos-Burgoa and L. Schwartz. 1993. Cancer epidemiology among styrenebutadiene rubber workers. In: M. Sorsa, K. Peltonen, H. Vainio and K. Hemminki (eds.), Butadiene and styrene: Assessment of health hazards. International Agency for Research on Cancer, Lyon. pp. 363-374 (IARC Scientific Publications No. 127).
  
  
• Matanoski, G., E. Elliott, X. Tao, M. Francis, A. Correa-Villasenor and C. Santos-Burgoa. 1997. Lymphohematopoietic cancers and butadiene and styrene exposure in synthetic rubber manufacture. Ann. N.Y. Acad. Sci. 837: 157-169.
  
  
• McAuliffe, C. 1966. Solubility in water of paraffin, cycloparaffin, olefin, acetylene, cycloolefin and aromatic hydrocarbons. J. Phys. Chem. 76: 1267-1275.
  
  
• McCarty, L.S. 1997. Personal communication from L.S. McCarty, L.S. McCarty Scientific Research & Consulting, Oakville, Ontario, to Commercial Chemicals Evaluation Branch, Environment Canada, Hull, Quebec.
  
  
• McKone, T.E., J.I. Daniels, F.F. Chiao and D.P.H. Hsieh. 1993. Intermedia transfer factors of fifteen toxic pollutants released to air basins in California. Lawrence Livermore National Laboratory, Livermore, California (UCRL-CR-115620).
  
  
• McMichael, A.J., R. Spirtas and L.L. Kupper. 1974. An epidemiologic study of mortality within a cohort of rubber workers, 1964-72. J. Occup. Med. 16: 458-464.
  
  
• McMichael, A.J., R. Spirtas, J.F. Gamble and P.M. Tousey. 1976. Mortality among rubber workers: Relationship to specific jobs. J. Occup. Med. 18: 178-185.
  
  
• McNeal, T.P. and C.V. Breder. 1987. Headspace gas chromatographic determination of residual 1,3-butadiene in rubber-modified plastics and its migration from plastic containers into selected foods. J. Assoc. Off. Anal. Chem. 70(1): 18-21.
  
  
• Meek, M.E., R. Newhook, R. Liteplo and V. Armstrong. 1994. Approach to assessment of risk to human health for Priority Substances under the Canadian Environmental Protection Act. Environ. Carcinogen. Ecotoxicol. Rev. C12(2): 105-134.
  
  
• Meinhardt, T.J., R.A. Lemen, M.S. Crandall and R.J. Young. 1982. Environmental epidemiologic investigation of the styrenebutadiene rubber industry. Scand. J. Work Environ. Health 8: 250-259.
  
  
• Melnick, R.L. and J.E. Huff. 1992. 1,3-Butadiene: Toxicity and carcinogenicity in laboratory animals and in humans. Rev. Environ. Contam. Toxicol. 124: 111-144.
  
  
• Melnick, R.L., J.E. Huff, J.H. Roycroft, B.J. Chou and R.A. Miller. 1990. Inhalation toxicology and carcinogenicity of 1,3-butadiene in B6C3F₁ mice following 65 weeks of exposure. Environ. Health Perspect. 86: 27-36.
  
  
• Meng, Q., L. Recio, A.A. Reilly, B.A. Wong, M. Bauer and V.E. Walker. 1998. Comparison of the mutagenic potency of 1,3-butadiene at hprt locus of T-lymphocytes following inhalation exposure of female B6C3F₁ mice and F344 rats. Carcinogenesis 19(6): 1019-1027.
  
  Top of Page
  
  
  
• Meng, Q., R.F. Henderson, A.A. Reilly, M. Bauer and V.E. Walker. Submitted(a). Relative contribution of epoxybutene versus diepoxybutane to the mutagenicity of butadiene following inhalation exposures of mice and rats. Submitted to Cancer Res.
  
  
• Meng, Q., N. Singh and V.E. Walker. Submitted(b). Comparison of the mutations at hprt exon 3 of T-lymphocytes from B6C3F₁ mice and F344 rats exposed by inhalation to 1,3-butadiene or 1,2:3,4-diepoxybutane. Submitted to Mutat. Res.
  
  
• Ministers' Expert Advisory Panel. 1995. Report of the Ministers' Expert Advisory Panel on the second Priority Substances List, under the Canadian Environmental Protection Act (CEPA). Government of Canada, Ottawa, Ontario. 26 pp.
  
  
• MOEE (Ontario Ministry of Environment and Energy). 1995. Technical memorandum - 1995 results of the Mobile TAGA 6000: 1,3-butadiene levels in Sarnia and selected areas in Ontario.
  
  
• Morrissey, R.E., B.A. Schwetz, P.L. Hackett, M.R. Sikov, B.D. Hardin, B.J. McClanahan, J.R. Decker and T.J. Mast. 1990. Overview of reproductive and developmental toxicity studies of 1,3-butadiene in rodents. Environ. Health Perspect. 86: 79-84.
  
  
• Nauhaus, S.K., T.R. Fennell, B. Asgharian, J.A. Bond and S.C.J. Sumner. 1996. Characterization of urinary metabolites from Sprague-Dawley rats and B6C3F₁ mice exposed to [1,2,3,4-¹³C]butadiene. Chem. Res. Toxicol. 9: 764-773.
  
  
• Neumann, H.-G., O. Albrecht, C. Van Dorp and I. Zwirner-Baier. 1995. Macromolecular adducts caused by environmental chemicals. Clin. Chem. 41(12): 1835-1840.
  
  
• Nikiforova, A.A., G.K. Ripp and I.I. Taskayev. 1969. Action of 1,3-butadiene on the structural elements of kidneys and heart. Nauchn. Tr. Omsk. Med. Inst. 88: 166-169.
  
  
• Norppa, H., A. Hirvonen, H. Jarventaus, M. Uuskula, G. Tasa, A. Ojajarvi and M. Sorsa. 1995. Role of GSTT1 and GSTM1 genotypes in determining individual sensitivity to sister chromatid exchange induction by diepoxybutane in cultured human lymphocytes. Carcinogenesis 16(6): 1261-1264.
  
  
• NTP (National Toxicology Program). 1984. NTP technical report on the toxicology and carcinogenesis studies of 1,3-butadiene (CAS No. 106-99-0) in B6C3F₁ mice (inhalation studies). U.S. Department of Health and Human Services, Research Triangle Park, North Carolina (Technical Report No. 288).
  
  
• NTP (National Toxicology Program). 1993. NTP technical report on the toxicology and carcinogenesis studies of 1,3-butadiene (CAS No. 106-99-0) in B6C3F₁ mice (inhalation studies). U.S. Department of Health and Human Services, Research Triangle Park, North Carolina (Technical Report No. 434).
  
  
• OECD (Organisation for Economic Co-operation and Development). 1996. Draft risk assessment of butadiene. Paris, March.
  
  
• Osterman-Golkar, S.M., J.A. Bond, J.B. Ward and M.S. Legator. 1993. Use of haemoglobin adducts for biomonitoring exposure to 1,3-butadiene. In: M. Sorsa, K. Peltonen, H. Vainio and K. Hemminki (eds.), Butadiene and styrene: Assessment of health hazards. International Agency for Research on Cancer, Lyon. pp. 185-193 (IARC Scientific Publications No. 127).
  
  
• Osterman-Golkar, S., K. Peltonen, T. Anttinen- Klemetti, H. Hindsø Landin, V. Zorcec and M. Sorsa. 1996. Haemoglobin adducts as biomarkers of occupational exposure to 1,3-butadiene. Mutagenesis 11(2): 145-149.
  
  
• Owen, P.E. and J.R. Glaister. 1990. Inhalation toxicity and carcinogenicity of 1,3-butadiene in Sprague-Dawley rats. Environ. Health Perspect. 86: 19-25.
  
  Top of Page
  
  
  
• Owen, P.E., J.R. Glaister, I.F. Gaunt and D.H. Pullinger. 1987. Inhalation toxicity studies with 1,3-butadiene: 3. Two year toxicity/carcinogenicity study in rats. Am. Ind. Hyg. Assoc. J. 48: 407-413.
  
  
• Pacchierotti, F., C. Tiveron, R. Ranaldi, B. Bassani, E. Cordelli, G. Leter and M. Spanò. 1998a. Reproductive toxicity of 1,3-butadiene in the mouse: cytogenetic analysis of chromosome aberrations in firstcleavage embryos and flow cytometric evaluation of spermatogonial cell killing. Mutat. Res. 397: 55-66.
  
  
• Pacchierotti, F., I.-D. Adler, D. Anderson, M. Brinkworth, N.A. Demopoulos, J. Lähdetie, S. Osterman-Golkar, K. Peltonen, A. Russo, A. Tates and R. Waters. 1998b. Genetic effects of 1,3-butadiene and associated risk for heritable damage. Mutat. Res. 397: 93-115.
  
  
• Pakdel, H., G. Couture, C. Roy, A. Masson, J. Locat, P. Gelinas and S. Lesage. 1992. Developing methods for the analysis of toxic chemicals in soil and groundwater: the case of Ville Mercier, Quebec, Canada. In: S. Lesage and R. Jackson (eds.), Groundwater contamination and analysis at hazardous waste sites. Marcel Dekker, Inc., New York, N.Y. pp. 381-421 (Environmental Science and Pollution Control Series).
  
  
• Paraskevopoulos, G., D.L. Singleton and R. McLaren. 1995. Hydrocarbon reactivity scales: a critical review. Report No. ER-1344-955, National Research Council, Institute for Environmental Research and Technology, Ottawa.
  
  
• Pelin, K., A. Hirvonen and H. Norppa. 1996. Influence of erythrocyte glutathione S-transferase T1 on sister chromatid exchanges induced by diepoxybutane in cultured human lymphocytes. Mutagenesis 11(2): 213-215.
  
  
• Pellizzari, E.D., L.C. Michael, K.W. Thomas, P.G. Shields and C. Harris. 1995. Identification of 1,3-butadiene, benzene, and other volatile organics from wok oil emissions. J. Expos. Anal. Environ. Epidemiol. 5(1): 77-87.
  
  
• Peltonen, K., P. Koivisto, I. Neagu, R. Kostiainen, I. Kelpelainen and M. Sorsa. 1993. Estimating internal dose of 1,3-butadiene: preliminary data on use of modified purine bases as markers of exposure. In: M. Sorsa, K. Peltonen, H. Vainio and K. Hemminki (eds.), Butadiene and styrene: Assessment of health hazards. International Agency for Research on Cancer, Lyon. pp. 119-126 (IARC Scientific Publications No. 127).
  
  
• Pérez, H.L., J. Lähdetie,, H.L. Landin, I. Kilpeläinene, P. Koivisto, K. Peltonen and S. Osterman-Golkar. 1997. Haemoglobin adducts of epoxybutanediol from exposure to 1,3-butadiene or butadiene epoxides. Chem.- Biol. Interact. 105: 181-198.
  
  
• Peto, R., M.C. Pike, L. Berstein, L.S. Gold and B.N. Ames. 1984. The TD₅₀: A proposed general convention for the numerical description of the carcinogenic potency of chemicals in chronic-exposure animal experiments. Environ. Health Perspect. 58: 1-8. ¡
  
  
• Preston, D.L., H. Kato, K.J. Kopecky and S. Fujita. 1987. Studies of the mortality of a-bomb survivors: 8. Cancer mortality, 1950-1982. Radiat. Res. 111: 151-178.
  
  
• Przygoda, R.T., M.G. Bird, F.T. Whitman, N.C. Wojcik and R.H. McKee. 1993. Induction of micronuclei in mice and hamsters by 1,3-butadiene. Environ. Mol. Mutagen. 21 (Suppl. 22): 56.
  
  
• Ramanathan, V., R.J. Cicerone, H.B. Singh and J.T. Kiehl. 1985. Trace gas trends and their potential role in climate change. J. Geophys. Res. 90: 5547-5566.
  
  
• Recio, L. and K.G. Meyer. 1995. Increased frequency of mutations at A:T base pairs in the bone marrow of B6C3F₁ lacI transgenic mice exposed to 1,3-butadiene. Environ. Mol. Mutagen. 26: 1-8.
  
  
• Recio, L., S. Osterman-Golkar, G.A. Csanády, M.J. Turner, B. Myhr, O. Moss and J.A. Bond. 1992. Determination of mutagenicity in tissues of transgenic mice following exposure to 1,3-butadiene and N-ethyl-N-nitrosourea. Toxicol. Appl. Pharmacol. 117: 58-64.
  
  Top of Page
  
  
  
• Recio, L., J.A. Bond, L.J. Pluta and S.C. Sisk. 1993. Use of transgenic mice for assessing the mutagenicity of 1,3-butadiene in vivo. In: M. Sorsa, K. Peltonen, H. Vainio and K. Hemminki (eds.), Butadiene and styrene: Assessment of health hazards. International Agency for Research on Cancer, Lyon. pp. 235-243 (IARC Scientific Publications No. 127).
  
  
• Recio, L., K.G. Meyer, L.J. Pluta, O.R. Moss and C.J. Saranko. 1996. Assessment of 1,3-butadiene mutagenicity in the bone marrow of B6C3F₁ lacI transgenic mice (Big Blue®): a review of mutational spectrum and lacI mutant frequency after a 5-day 625 ppm 1,3-butadiene exposure. Environ. Mol. Mutagen. 28: 424-429.
  
  
• Recio, L., R.F. Henderson, L.J. Pluta, K. Meyer, C.J. Saranko and A.-M. Steen. 1998. Analysis of mutagenicity and determination of mutational spectrum in rodent and human cells to assess the roles of epoxybutene and diepoxybutane in mediating the in vivo genotoxicity of 1,3-butadiene. In: Proceedings of the 14th Health Effects Institute Annual Conference. p. 49 [cited in Meng et al., submitted(a)].
  
  
• Ripp, G.K. 1967. Hygiene basis for the permissible concentration of butadiene in the atmosphere. Biol. Deistvie Gig. Znach. Atmos. Zagryaz. 10: 33-54.
  
  
• Ristau, C., S. Deutschmann, R.J. Laib and H. Ottenwalder. 1990. Detection of diepoxybutane-induced DNA-DNA crosslinks by cesium trifluoracetate (CsTFA) densitygradient centrifugation. Arch. Toxicol. 64: 343-344.
  
  
• Ross, D., D. Siegel, D.G. Schattenberg, X.M. Sun and J.L. Moran. 1996b. Cellspecific activation and detoxification of benzene metabolites in mouse and human bone marrow: identification of target cells and a potential role for modulation of apoptosis in benzene toxicity. Environ. Health Perspect. 104 (Suppl. 6): 1177-1182.
  
  
• Russo, A., C. Nogara, L. Renzi and A.M. Tommasi. 1997. Micronucleus induction in germ and somatic cells of the mouse after exposure to the butadiene metabolites diepoxybutane and epoxybutene. Mutat. Res. 390: 129-139.
  
  
• Sabourin, P.J., L.T. Burka, W.E. Bechtold, A.R. Dahl, M.D. Hoover, I.Y. Chang and R.F. Henderson. 1992. Species differences in urinary butadiene metabolites; identification of 1,2-dihydroxy-4-(N-acetylcysteinyl)butane, a novel metabolite of butadiene. Carcinogenesis 13(9): 1633-1638.
  
  
• Santos-Burgoa, C., G.M. Matanoski, S. Zeger and L. Schwartz. 1992. Lympho-hematopoietic cancer in styrene-butadiene polymerization workers. Am. J. Epidemiol. 136: 843-854.
  
  
• Saranko, C.J. and L. Recio. 1998. The butadiene metabolite, 1,2:3,4-diepoxybutane, induces micronuclei but is only weakly mutagenic at lacI in the Big Blue® Rat2 lacI transgenic cell line. Environ. Mol. Mutagen. 31: 32-40.
  
  
• Saranko, C.J., L.J. Pluta, L. Recio and R.F. Henderson. 1998. in vivo and in vitro mutagenicity spectrum of the butadiene metabolite 1,2-epoxybutene. Proc. Am. Assoc. Cancer Res. 39: 330 (abstract only).
  
  
• Sasiadek, M., H. Järventaus and M. Sorsa. 1991a. Sister-chromatid exchanges induced by 1,3- butadiene and its epoxides in CHO cells. Mutat. Res. 263: 47-50.
  
  
• Sasiadek, M., H. Norppa and M. Sorsa. 1991b. 1,3-Butadiene and its epoxides induce sisterchromatid exchanges in human lymphocytes in vitro . Mutat. Res. 261: 117-121.
  
  
• Sathiakumar, N., E. Delzell, M. Hovinga, M. Macaluso, J.A. Julian, R. Larson, P. Cole and D.C.F. Muir. 1998. Mortality from cancer and other causes of death among synthetic rubber workers. Occup. Environ. Med. 55: 230-235.
  
  
• Schattenberg, D.G., W.S. Stillman, J.J. Gruntmeir, K.M. Helm, R.D. Irons and D. Ross. 1994. Peroxidase activity in murine and human hematopoietic progenitor cells: potential relevance to benzene-induced toxicity. Mol. Pharmacol. 46: 346-351.
  
  Top of Page
  
  
  
• Schuetzle, D., W.O. Siegl, T.E. Jensen, M.A. Dearth, E.W. Kaiser, R. Gorse, W. Kreucher and E. Kulik. 1994. The relationship between gasoline composition and vehicle hydrocarbon emissions: a review of current studies and future research needs. Environ. Health Perspect. 102 (Suppl. 4): 3-12.
  
  
• Sernau, R., J. Cavagnaro and P. Kehn. 1986. 1,3-Butadiene as an S9 activation-dependent gaseous positive control substance in L5178Y cell mutation assays. Environ. Mutagen. (Suppl. 8): 75 (Abstract 203).
  
  
• Sharer, J.E., R.J. Duescher and A.A. Elfarra. 1992. Species and tissue differences in the microsomal oxidation of 1,3-butadiene and the glutathione conjugation of butadiene monoxide in mice and rats. Drug Metab. Dispos. 20: 658-664.
  
  
• Sharief, Y., A.M. Brown, L.C. Backer, J.A. Campbell, B. Westbrook-Collins, A.G. Stead and J.W. Allen. 1986. Sister chromatid exchange and chromosome aberration analyses in mice after in vivo exposure to acrylonitrile, styrene, or butadiene monoxide. Environ. Mutagen. 8: 439-448.
  
  
• Shelby, M.D. 1990. Results of NTP-sponsored mouse cytogenetic studies on 1,3-butadiene, isoprene, and chloroprene. Environ. Health Perspect. 86: 71-73.
  
  
• Shields, P.G., G.X. Xu, W.J. Blot, J.F. Fraumeni, Jr., G.E. Trivers, E.D. Pellizzari, Y.H. Qu, Y.T. Gao and C.C. Harris. 1995. Mutagens from heated Chinese and U.S. cooking oils. J. Natl. Cancer Inst. 887(110): 836-841.
  
  
• Shugaev, B. 1969. Concentrations of hydrocarbons in tissues as a measure of toxicity. Arch. Environ. Health 18: 878-882.
  
  
• Siemiatycki, J. 1991. Risk factors for cancer in the workplace. CRC Press, Boca Raton, Florida.
  
  
• Sisk, S.C., L.J. Pluta, J.A. Bond and L. Recio. 1994. Molecular analysis of lacI mutants from bone marrow of B6C3F₁ transgenic mice following inhalation exposure to 1,3- butadiene. Carcinogenesis 15: 471-477.
  
  
• Sorsa, M., J. Autio, N.A. Demopoulos, H. Jarventaus, P. Rossner, R.J. Srám, G. Stephanou and D. Vlachodimitropoulos. 1994. Human cytogenetic biomonitoring of occupational exposure to 1,3-butadiene. Mutat. Res. 309: 321-326. ¡
  
  
• Sorsa, M., S. Osterman-Golkar, K. Peltonen, S.T. Saarikoski and R. Sram. 1996a. Assessment of exposure to butadiene in the process industry. Toxicology 113: 77-83.
  
  
• Sorsa, M., K. Peltonen, D. Anderson, N.A. Demopoulos, H.-G. Neumann and S. Osterman-Golkar. 1996b. Assessment of environmental and occupational exposures to butadiene as a model for risk estimation of petrochemical emissions. Mutagenesis 11(1): 9-17.
  
  
• Spano, M., C. Bartoleschi, E. Cordelli, G. Leter, L. Segre, A. Mantovani, P. Fazzi and F. Pacchierotti. 1996. Flow cytometric and histological assessment of 1,2:3,4- diepoxybutane toxicity on mouse spermatogenesis. J. Toxicol. Environ. Health 47: 423-441.
  
  
• Srám, R.J., P. Rössner, K. Peltonen, K. Podrazilová, G. Mracková, N.A. Demopoulos, G. Stephanou, D. Vladimiropoulos, F.J. van Dam and A.D. Tates 1998. Chromosomal aberrations, sister-chromatid exchanges, cells with high frequency of SCE, micronuclei and Comet assay parameters in 1,3-butadiene exposed workers. Mutat. Res. 419 (1-3): 145-154.
  
  
• Startin, J.R. and J. Gilbert. 1984. Single ion monitoring of butadiene in plastics and foods by coupled mass spectrometry-automatic headspace gas chromatography. J. Chromatogr. 294: 427-430.
  
  Top of Page
  
  
  
• Steer, P. 1996. Letter dated August 28, 1996, to J. Sealy, Health Canada, from P. Steer, Ontario Ministry of Environment and Energy, Science and Technology Branch, re. 1,3-butadiene and chloroform data (File No. 1E080149.MEM).
  
  
• Stephanou, G., C. Andrianopoulos, D. Vlastos, N.A. Demopoulos and A. Russo. 1997. Induction of micronuclei and sister chromatid exchange in mouse splenocytes after exposure to the butadiene metabolite 3,4-epoxy-1-butene. Mutagenesis 12(6): 425-429.
  
  
• Stephanou, G., A. Russo, D. Vlastos, C. Andrianopoulos and N.A. Demopoulos. 1998. Micronucleus induction in somatic cells of mice as evaluated after 1,3-butadiene inhalation. Mutat. Res. 397: 11-20.
  
  
• Swann, R.L., D.A. Laskowski, P.J. McCall, K. Vander Kuy and H.J. Dishburger. 1983. A rapid method for the estimation of the environmental parameters octanol/water partition coefficient, soil sorption constant, water to air ratio and water solubility. Residue Rev. 85: 17-28.
  
  
• Sweeney, L.M., P.M. Schlosser, M.A. Medinsky and J.A. Bond. 1997. Physiologically based pharmacokinetic modeling of 1,3-butadiene, 1,2-epoxy-3-butene, and 1,2:3,4-diepoxybutane toxicokinetics in mice and rats. Carcinogenesis 18(4): 611-625.
  
  
• Swenberg, J.A. 1998. Personal communication to Health Canada. Correspondence dated March 25, 1998. University of North Carolina, Chapel Hill, North Carolina.
  
  
• Tates, A.D., F.J. van Dam, F.A. de Zwart, C.M.M. van Teylingen and A.T. Natarajan. 1994. Development of a cloning assay with high cloning efficiency to detect induction of 6-thioguanine-resistant lymphocytes in spleen of adult mice following in vivo inhalation exposure to 1,3-butadiene. Mutat. Res. 309: 299-306.
  
  
• Tates, A.D., F.J. van Dam, F.A. de Zwart, F. Darroudi, A.T. Natarajan, P. Rössner, K. Peterková, K. Peltonen, N.A. Demopoulos, G. Stephanou, D. Vlachodimitropoulos and R.J. Srám. 1996. Biological effect monitoring in industrial workers from the Czech Republic exposed to low levels of butadiene. Toxicology 113: 91-99.
  
  
• Tates, A.D., F.J. van Dam, C.M.M. van Teylingen, F.A. de Zwart and A.H. Zwinderman. 1998. Comparison of induction of hprt mutations by 1,3-butadiene and/or its metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane in lymphocyes from spleen of adult male mice and rats in vivo. Mutat. Res. 397: 21-36.
  
  
• Thier, R., M. Persmark, S.E. Pemble, J.B. Taylor, B. Ketterer and F.P. Guengerich. 1994. Mutagenicity of 1,2,3,4-butadiene diepoxide is altered by mammalian è-class glutathione S-transferase. Arch. Pharmacol. 349 (Suppl.): R121.
  
  
• Thornton-Manning, J.R., A.R. Dahl, W.E. Bechtold, W.C. Griffith and R.F. Henderson. 1995a. Disposition of butadiene monoepoxide and butadiene diepoxide in various tissues of rats and mice following a low-level inhalation exposure to 1,3-butadiene. Carcinogenesis 16(8): 1723-1731.
  
  
• Thornton-Manning, J.R., A.R. Dahl, W.E. Bechtold, W.C. Griffith, L. Pei and R.F. Henderson. 1995b. Gender differences in the metabolism of 1,3-butadiene in Sprague- Dawley rats following a low level inhalation exposure. Carcinogenesis 16(11): 2875-2878.
  
  
• Thornton-Manning, J.R., A.R. Dahl, W.E. Bechtold, W.C. Griffith, Jr. and R.F. Henderson. 1997. Comparison of the disposition of butadiene epoxides in Sprague- Dawley rats and B6C3F₁ mice following a single and repeated exposures to 1,3- butadiene via inhalation. Toxicology 123: 125-134.
  
  
• Thornton-Manning, J.R., A.R. Dahl, M.L. Allen, W.E. Bechtold, W.C. Griffith, Jr. and R.F. Henderson. 1998. Disposition of butadiene epoxides in Sprague-Dawley rats following exposures to 8000 ppm 1,3-butadiene: comparisons with tissue epoxide concentrations following low level exposures. Toxicol. Sci. 41: 167-173.
  
  
• Thurmond, L.M., L.D. Lauer, R.V. House, W.S. Stillman, R.D. Irons, W.H. Steinhagen and J.H. Dean. 1986. Effect of short-term inhalation exposure to 1,3-butadiene on murine immune functions. Toxicol. Appl. Pharmacol. 86: 170-179.
  
  Top of Page
  
  
  
• Tice, R.R., R. Boucher, C.A. Luke and M.D. Shelby. 1987. Comparative cytogenetic analysis of bone marrow damage induced by male B6C3F₁ mice by multiple exposures to gaseous 1,3-butadiene. Environ. Mutagen. 9: 235-250.
  
  
• Tiveron, C., R. Ranaldi, B. Bassani and F. Pacchierotti. 1997. Induction and transmission of chromosome aberrations in mouse oocytes after treatment with butadiene epoxide. Environ. Mol. Mutagen. 30: 403-409.
  
  
• Tommasi, A.M., S. De Conti, M.M. Dobrzynska and A. Russo. 1998. Evaluation and characterization of micronuclei in early spermatids of mice exposed to 1,2-butadiene. Mutat. Res. 397: 45-54.
  
  
• Tretyakova, N.Y., Y.-P. Lin, P.B. Upton, R. Sangaiah and J.A. Swenberg. 1996. Macromolecular adducts of butadiene. Toxicology 113: 70-76.
  
  
• Tretyakova, N.Y., S.-Y. Chiang, V.E. Walker and J.A. Swenberg. 1998a. Quantitative analysis of 1,3-butadiene-induced DNA adducts in vivo and in vitro using liquid chromatography electrospray ionization tandem mass spectrometry. J. Mass Spectrom. 33: 363-376.
  
  
• Tretyakova, N.Y., V.E. Walker and J.A. Swenberg. 1998b. Formation and persistence of DNA adducts in liver of rats and mice exposed to 1,3-butadiene. In: Proceedings of Society of Toxicology 1998 Annual Meeting. p. 180 (Abstract No. 890).
  
  
• U.S. DHHS (Department of Health and Human Services). 1989. Reducing the health consequences of smoking. 25 years of progress. A report of the Surgeon General. Rockville, Maryland.
  
  
• U.S. EPA (United States Environmental Protection Agency). 1989. Locating and estimating air emissions from sources of 1,3-butadiene. Office of Air Quality Planning and Standards (EPA/450/2-89/021).
  
  
• U.S. EPA (United States Environmental Protection Agency). 1991. Fish chronic toxicity data base. Environmental Research Laboratory, Office of Research and Development, Duluth, Minnesota.
  
  
• U.S. EPA (United States Environmental Protection Agency). 1993. Motor vehiclerelated air toxics study. Office of Mobile Sources Emission Planning and Strategies Division, April (EPA 420-R-93-005).
  
  
• Uuskula, M., H. Jarventaus, A. Hirvonen, M. Sorsa and H. Norppa. 1995. Influence of GSTM1 genotype on sister chromatid exchange induction by styrene-7,8-oxide and 1,2-epoxy-3-butene in cultured human lymphocytes. Carcinogenesis 16(4): 947-950.
  
  
• Van Duuren, B.L., N. Nelson, L. Orris, E.D. Palmes and F.L. Schmitt. 1963. Carcinogenicity of epoxides, lactones, and peroxy compounds. J. Natl. Cancer Inst. 31: 41-55 [cited in IARC, 1992].
  
  
• Van Duuren, B.L., L. Orris and N. Nelson. 1965. Carcinogenicity of epoxides, lactones, and peroxy compounds. Part II. J. Natl. Cancer Inst. 35: 707-717 [cited in IARC, 1992].
  
  
• Van Duuren, B.L., L. Langseth, L. Orris, G. Teebor, N. Nelson and M. Kuschner. 1966. Carcinogenicity of epoxides, lactones, and peroxy compounds. IV. Tumor response in epithelial and connective tissue in mice and rats. J. Natl. Cancer Inst. 37: 825-838.
  
  
• Vangala, R.R., R.J. Laib and H.M. Bolt. 1993. Evaluation of DNA damage by alkaline elution technique after inhalation exposure of rats and mice to 1,3-butadiene. Arch. Toxicol. 67: 34-38.
  
  Top of Page
  
  
  
• Veith, G.D., D.J. Call and L.T. Brooke. 1983. Structure toxicity relationships for the fathead minnow, Pimephales promelas: narcotic industrial chemicals. Can. J. Fish. Aquat. Sci. 40: 473-748.
  
  
• Victorin, K. and M. Ståhlberg. 1988. A method for studying the mutagenicity of some gaseous compounds in Salmonella typhimurium. Environ. Mol. Mutagen. 11: 65-77.
  
  
• Victorin, K., L. Busk, H. Cederberg and J. Magnusson. 1990. Genotoxic activity of 1,3-butadiene and nitrogen dioxide and their photochemical reaction products in Drosophila and in the mouse bone marrow micronucleus assay. Mutat. Res. 228: 203-209.
  
  
• Vincent, D.R., G.T. Arce and A.M. Sarrif. 1986. Genotoxicity of 1,3-butadiene. Assessment by the unscheduled DNA synthesis assay in B6C3F₁ mice and Sprague-Dawley rats in vivo and in vitro . Environ. Mutagen., Suppl. 8: 88.
  
  
• Vlachodimitropoulos, D., H. Norppa, K. Autio, J. Catalán, A. Hirvonen, G. Tasa, M. Uusküla, N.A. Demopoulos and M. Sorsa. 1997. GSTT1-dependent induction of centromerenegative and -positive micronuclei by 1,2:3,4-diepoxybutane in cultured human lymphocytes. Mutagenesis 12(5): 397-403.
  
  
• Walk, R.-A., J. Jenderny, G. Röhrborn and U. Hackenberg. 1987. Chromosomal abnormalities and sister-chromatid exchange in bone marrow of mice and Chinese hamsters after inhalation and intraperitoneal administration: I. Diepoxybutane. Mutat. Res. 182: 333-342.
  
  
• Walles, S.A.S., K. Victorin and M. Lundborg. 1995. DNA damage in lung cells in vivo and in vitro by 1,3-butadiene and nitrogen dioxide and their photochemical reaction products. Mutat. Res. 328: 11-19.
  
  
• Wang, W.C., Y.L. Yung, A.A. Lacis, T. Mo and J.E. Hansen. 1976. Greenhouse effects due to man-made perturbations of trace gases. Science 194: 685-689.
  
  
• Ward, D.E. and W.M. Hao. 1992. Air toxic emissions from the burning of biomass globally - preliminary estimates. Presented at the 85th Annual Meeting of the Air and Waste Management Association, Kansas City, Missouri.
  
  
• Ward, E.M., J.M Fajen, A.M. Ruder, R.A. Rinsky, W.E. Halperin and C.A. Fessler-Flesch. 1995. Mortality study of workers in 1,3-butadiene production units identified from a chemical workers cohort. Environ. Health Perspect. 103(6): 598-603.
  
  
• Ward, E.M., J.M. Fajen, A.M. Ruder, R.A. Rinsky, W.E. Halperin and C.A. Fessler- Flesch. 1996. Mortality study of workers employed in 1,3-butadiene production units identified from a chemical workers cohort. Toxicology 113: 157-168.
  
  
• Ward, J.B., Jr. 1997a. Personal communication to Health Canada. Letter dated October 17, 1997. Division of Environmental Toxicology, Department of Preventative Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas.
  
  
• Ward, J.B., Jr. 1997b. Personal communication. Electronic correspondence dated November 15, 1997. Division of Environmental Toxicology, Department of Preventative Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas.
  
  
• Ward, J.B., Jr., M.M. Ammenheuser, W.E. Bechtold, E.B. Whorton, Jr. and M.S. Legator. 1994. hprt mutant lymphocyte frequencies in workers at a 1,3-butadiene production plant. Environ. Health Perspect. 102 (Suppl. 9): 79-85.
  
  
• Ward, J.B., Jr., M.M. Ammenheuser, E.B. Whorton, Jr., W.E. Bechtold, K.T. Kelsey and M.S. Legator. 1996. Biological monitoring for mutagenic effects of occupational exposure to butadiene. Toxicology 113: 84-90.
  
  Top of Page
  
  
  
• Weast, R.C. (ed.). 1984. Handbook of chemistry and physics. 65th ed. CRC Press, Boca Raton, Florida.
  
  
• Wiencke, J.K. and K.T. Kelsey. 1993. Susceptibility to induction of chromosomal damage by metabolites of 1,3-butadiene and its relationship to "spontaneous" sister chromatid exchange frequencies in human lymphocytes. In: M. Sorsa, K. Peltonen, H. Vainio and K. Hemminki (eds.), Butadiene and styrene: Assessment of health hazards. International Agency for Research on Cancer, Lyon. pp. 265-273 (IARC Scientific Publications No. 127).
  
  
• Wiencke, J.K., S. Pemble, B. Ketterer and K.T. Kelsey. 1995. Gene deletion of glutathione S-transferase Θ: correlation with induced genetic damage and potential role in endogenous mutagenesis. Cancer Epidemiol. Biomarkers Prev. 4: 253-259.
  
  
• Wilson, A.L., S.D. Colome and Y. Tian. 1991. Air toxics microenvironmental exposure and monitoring study. Final report. Prepared for South Coast Air Quality Management District, El Monte, California, and U.S. Environmental Protection Agency by Integrated Environmental Services, Irvine, California.
  
  
• Xi, L., L. Zhang, Y. Wang and M.T. Smith. 1997. Induction of chromosome-specific aneuploidy and micronuclei in human lymphocytes by metabolites of 1,3-butadiene. Carcinogenesis 18(9): 1687-1693.
  
  
• Xiao, Y. and A.D. Tates. 1995. Clastogenic effects of 1,3-butadiene and its metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane in splenocytes and germ cells of rats and mice in vivo. Environ. Mol. Mutagen. 26: 97-108.
  
  
• Zaroogian, G., J.F. Heltshe and M. Johnson. 1985. Estimation of toxicity to marine species with structure activity models developed to estimate toxicity to fresh water fish. Aquat. Toxicol. 6: 251-270.