Priority Substances List Assessment Report for Butylbenzylphthalate

Environment Canada
Health Canada
2000
ISBN: 0-662-28192-6
Cat. No.: En 40-215/44E

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Canadian Environmental Protection Act 1999

Table of Contents

• List of acronyms and abbreviations
• Synopsis
• 1.0 Introduction
• 2.0 Summary of information critical to assessment of "Toxic" under CEPA
  • 2.1 Identity and physical/chemical properties
  • 2.2 Entry characterization
    • 2.2.1 Production, importation and uses
    • 2.2.2 Sources and releases
      • 2.2.2.1 Natural sources
      • 2.2.2.2 Anthropogenic sources
  • 2.3 Exposure characterization
    • 2.3.1 Environmental fate
      • 2.3.1.1 Air
      • 2.3.1.2 Water
      • 2.3.1.3 Sediments
      • 2.3.1.4 Soils
      • 2.3.1.5 Biota
      • 2.3.1.6 Environmental partitioning
    • 2.3.2 Environmental concentrations
      • 2.3.2.1 Ambient air
      • 2.3.2.2 Surface water
      • 2.3.2.3 Sediments
      • 2.3.2.4 Soils
      • 2.3.2.5 Biota
      • 2.3.2.6 Food
      • 2.3.2.7 Drinking water
      • 2.3.2.8 Indoor air
      • 2.3.2.9 Consumer products
  • 2.4 Effects characterization
    • 2.4.1 Ecotoxicology
      • 2.4.1.1 Pelagic organisms
      • 2.4.1.2 Benthic organisms
      • 2.4.1.3 Soil organisms
      • 2.4.1.4 Terrestrial plants
      • 2.4.1.5 Wildlife
      • 2.4.1.6 Endocrine modulation
    • 2.4.2 Abiotic atmospheric effects
    • 2.4.3 Experimental animals and in vitro
      • 2.4.3.1 Acute toxicity
      • 2.4.3.2 Short-term toxicity
      • 2.4.3.3 Subchronic toxicity
      • 2.4.3.4 Chronic toxicity and carcinogenicity
      • 2.4.3.5 Genotoxicity
      • 2.4.3.6 Reproductive and developmental toxicity
      • 2.4.3.7 Irritation and sensitization
      • 2.4.3.8 Peroxisomal proliferation
      • 2.4.3.9 Neurological and immunological effects
      • 2.4.3.10 Toxicokinetics and mechanism of action
    • 2.4.4 Humans
• 3.0 Assessment of "Toxic" under CEPA
  • 3.1 CEPA 11(a): Environment
    • 3.1.1 Assessment endpoints
    • 3.1.2 Environmental risk characterization
      • 3.1.2.1 Pelagic organisms
      • 3.1.2.2 Benthic organisms
      • 3.1.2.3 Soil organisms
      • 3.1.2.4 Terrestrial plants
      • 3.1.2.5 Terrestrial wildlife
      • 3.1.2.6 Sources of uncertainty
  • 3.2 CEPA 11(b): Enviro nment upon which human life depends
  • 3.3 CEPA 11(c): Human health
    • 3.3.1 Estimated population exposure
    • 3.3.2 Hazard characterization
    • 3.3.3 Dose-response analyses
    • 3.3.4 Human health risk characterization
    • 3.3.5 Uncertainties and degree of confidence in human health risk characterization
  • 3.4 Conclusions
  • 3.5 Considerations for follow-up (further action)
• 4.0 References
• Appendix A search strategies employed for identification of relevant Data

List of Tables

• Table 1 - Sources and releases of BBP
• Table 2 - Benchmark doses for non-neoplastic effects of BBP
• Table 3 - Risk characterization summary for environmental effects of BBP
• Table 4 - Estimated average daily intake of BBP by the population of Canada
• Table 5 - Reasonable worst-case estimates of daily intake of BBP
• Table 6 - Benchmark doses for pancreatic hyperplasia and tumorigenic dose - NTP two-year bioassay

List of Figures

• Figure 1 - Structure of BBP
• Figure 2 - Benchmark dose (BMD) for incidence of pancreatic lesions in male Wistar rats exposed to BBP via the diet for three months
• Figure 3 - Benchmark dose (BMD) for incidence of renal proximal tubular regeneration in male F344 rats exposed to BBP via the diet for two weeks
• Figure 4 - Benchmark dose (BMD) for incidence of renal nephropathy in female F344/N rats exposed to BBP via the diet for two years