Priority Substances List Assessment Report for Carbon Disulfide

Environment Canada
Health Canada
2000
ISBN: 0-662-28496-8
Cat. No.: En40-215/46E

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Canadian Environmental Protection Act, 1999

Table of Contents

• List of Acronyms and Abbreviations
• Synopsis
• 1.0 Introduction
• 2.0 Summary of Information Critical to Assessment of "Toxic" Under CEPA 1999
  • 2.1 Identity and physical/chemical properties
  • 2.2 Entry characterization
    • 2.2.1 Production, importation, exportation and use
    • 2.2.2 Sources and releases
      • 2.2.2.1 Natural sources
      • 2.2.2.2 Anthropogenic sources
  • 2.3 Exposure characterization
    • 2.3.1 Environmental fate
      • 2.3.1.1 Air
      • 2.3.1.2 Water
      • 2.3.1.3 Sediment
      • 2.3.1.4 Soils
      • 2.3.1.5 Biota
      • 2.3.1.6 Environmental distribution
    • 2.3.2 Environmental concentrations
      • 2.3.2.1 Ambient (outdoor) air
      • 2.3.2.2 Indoor air
      • 2.3.2.3 Surface water and groundwater
      • 2.3.2.4 Drinking water
      • 2.3.2.5 Soil and sediment
      • 2.3.2.6 Biota
      • 2.3.2.7 Food
      • 2.3.2.8 Consumer products
    • 2.3.3 Human tissues and fluids
  • 2.4 Effects characterization
    • 2.4.1 Ecotoxicology
      • 2.4.1.1 Terrestrial organisms
      • 2.4.1.2 Aquatic organisms
    • 2.4.2 Abiotic atmospheric effects
    • 2.4.3 Humans
      • 2.4.3.1 Acute effects
      • 2.4.3.2 Effects of long-term exposure
        • 2.4.3.2.1 Effects on the nervous system
        • 2.4.3.2.2 Mortality from cardiovascular disease
        • 2.4.3.2.3 Cardiovascular morbidity and risk factors for cardiovascular disease
        • 2.4.3.2.4 Effects on the eye
        • 2.4.3.2.5 Carcinogenicity
        • 2.4.3.2.6 Effects on reproduction and development
        • 2.4.3.2.7 Other effects
    • 2.4.4 Experimental animals and in vitro
      • 2.4.4.1 Acute toxicity
      • 2.4.4.2 Repeated exposure
        • 2.4.4.2.1 Inhalation
        • 2.4.4.2.2 Oral
        • 2.4.4.2.3 Carcinogenicity
        • 2.4.4.2.4 Genotoxicity
        • 2.4.4.2.5 Effects on reproduction and development
    • 2.4.5 Toxicokinetics and mode of action
• 3.0 ASSESSMENT OF "TOXIC" UNDER CEPA 1999
  • 3.1 CEPA 1999 64(a): Environment
    • 3.1.1 Assessment endpoints
      • 3.1.1.1 Terrestrial organisms
      • 3.1.1.2 Aquatic organisms
    • 3.1.2 Environmental risk characterization
      • 3.1.2.1 Terrestrial organisms
      • 3.1.2.2 Aquatic organisms
      • 3.1.2.3 Discussion of uncertainty
• 3.2 CEPA 1999 64(b): Environment on which life depends
• 3.3 CEPA 1999 64(c): Human health
  • 3.3.1 Estimated population exposure
  • 3.3.2 Hazard characterization
  • 3.3.3 Exposure-response analyses
  • 3.3.4 Human health risk characterization
  • 3.3.5 Uncertainties and degree of confidence in human health risk characterization
• 3.4 Conclusions
• 3.5 Considerations for follow-up (further action)
• 4.0 References
• Appendix A Search Strategies Employed for Identification of Relevant Data

List of Tables

• Table 1 Physical and chemical properties of carbon disulfide
• Table 2 Summary of major anthropogenic releases in Canada
• Table 3 Average maximum air concentrations derived from ISC 3 model predictions
• Table 4 Summary risk quotients for carbon disulfide for CEPA 1999 64(a)
• Table 5 Estimated mean intakes of carbon disulfide for the general population of Canada
• Table 6 Final BMC₀₅s and BMCL₀₅s for selected outcome variables