Alberta Environmental Protection. 1996. Data summary prepared for the Priority Substances Section, Environmental Protection Services, Municipal Water and Wastewater Branch, Air and Water Approval Division, Edmonton,
Alberta.
Anders, M.W. and I. Jakobson. 1985. Biotransformation of halogenated solvents. International Conference on Organic Solvent Toxicity, Stockholm, Sweden, October 15-17, 1984. Scand. J. Work Environ. Health 11(Suppl. 1): 23-32.
ATSDR (Agency for Toxic Substances and Disease Registry). 1994. Toxicological profile for hexachlorobutadiene. Public Health Service, U.S. Department of Health and Human Services (Publication No. TP-93/08).
Bedard, D. and S. Petro. 1997. Laboratory sediment bioassay report on Upper St. Clair River sediments in the vicinity of industrial point sources - 1994 & 1995. St. Clair River Remedial Action Plan, Toronto, Ontario. 76 pp.
Benoit, D.A., F.A. Puglisi and D.L. Olson. 1982. A fathead minnow (Pimephales promelas) early life stage toxicity test method evaluation and exposure to 4 organic chemicals. Environ. Pollut. Ser. A, Ecol. Biol. 28: 189-198.
Birner, G., M. Werner, M.M. Ott and W. Dekant. 1995. Sex differences in hexachlorobutadiene biotransformation and nephrotoxicity. Toxicol. Appl. Pharmacol. 132: 203-212.
Brown, S.L., F.Y. Chan, J.L. Jones, D.H. Liu, K.E. McCaleb, T. Mill, K.N. Sapios and D.E. Schendel. 1975. Research program on hazard priority ranking of manufactured chemicals (chemicals 1-20). Stanford Research Institute, Menlo Park, California (NSF/RA/E-75/190A.-PB263161).
Bunce, N. 1996. Atmospheric properties of substances on the Priority Substances List #2 (PSL2). Report to Environment Canada. University of Guelph, Guelph, Ontario. 13 pp.
Chan, C.H. 1993. St. Clair River head and mouth water quality monitoring, 1987-89. Water Pollut. Res. J. Can. 28(2): 451-471.
Chiou, C.T. 1985. Partition coefficients of organic compounds in lipid-water systems and correlations with fish bioconcentration factors. Environ. Sci. Technol. 19(1): 57-62.
Choudhary, G. 1995. Human health perspectives on environmental exposure to hexachlorobutadiene: a review. Environ. Carcinogen. Ecotoxicol. Rev. C13(2): 179-203.
Clark, J.R., D. DeVault, R.J. Bowden and J.A. Weishaar. 1984. Contaminant analysis of fillets from Great Lakes coho salmon, 1980. J. Great Lakes Res. 10(1): 38-47.
Class, T. and K. Ballschmiter. 1987. Global baseline pollution studies. X. Atmospheric halocarbons: global budget estimations for tetrachloroethene, 1,2-dichloroethane, 1,1,1,2-tetrachloroethane, hexachloroethane, hexachlorobutadiene. Estimation of the hydroxyl radical concentrations in the troposphere of the Northern and Southern Hemisphere. Fresenius Z. Anal. Chem. 327(2): 198-204.
Dann, T. 1997. Summary of hexachlorobutadiene concentrations at Canadian sites. Air Toxics Section, Environmental Technology Service, Environmental Protection Service, Environment Canada.
Dekant, W., S. Vamvakas, K. Berthold, S. Schmidt, D. Wild and D. Henschler. 1986. Bacterial b-lyase mediated cleavage and mutagenicity of cysteine conjugates derived from the nephrocarcinogenic alkenes, trichloroethylene, tetrachloroethylene, and hexachlorobutadiene. Chem. Biol. Interact. 60: 31-45.
Dekant, W., S. Vamvakas, M. Koob, A. Kochlin, W. Kanhai, D. Muller and D. Henschler. 1990. A mechanism of haloalkene-induced renal carcinogenesis. Environ. Health Perspect. 88: 107-110.
De Meester, C., M. Mercier and F. Poncelet. 1980. Mutagenic activity of butadiene, hexachlorobutadiene, and isoprene. Ind. Environ. Xenobiotics, Proc. Int. Conf. pp. 195-203 [cited in ATSDR, 1994].
Di Toro, D.M., C.S. Zarba, D.J. Hansen, W.J. Berry, R.C. Swartz, C.E. Cowan, S.P. Pavlou, H.E. Allen, N.A. Thomas and P.R. Paquin. 1991. Technical basis for establishing sediment quality criteria for nonionic organic chemicals using equilibrium partitioning. Environ. Toxicol. Chem. 10: 1541-1583.
DMER (Don Mackay Environmental Research) and AEL (Angus Environmental Limited). 1996. Pathways analysis of hexachlorobutadiene for the second Priority Substances List using fugacity modelling. Report prepared for the Chemicals Evaluation Division, Commercial Chemicals Evaluation Branch, Environment Canada, by DMER, Peterborough, Ontario, and AEL, Don Mills, Ontario, March 1996.
Dow Chemical Co. 1978. The acute fish toxicity of hexachlorobutadiene and hexachloroethane to the sheepshead minnow (Cyprinodon variegatus). The Dow Chemical Company, Midland, Michigan (TWC 103).
Driscoll, T.R., H.H. Hamdan, G. Wang, P.F.A. Wright and N.H. Stacey. 1992. Concentrations of individual serum or plasma bile acids in workers exposed to chlorinated aliphatic hydrocarbons. Br. J. Ind. Med. 49: 700-705.
Elwell, M.R. 1993. Personal communication with B. Mintz, U.S. Environmental Protection Agency. Letter dated April 21, 1993, from M.R. Elwell, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
Environment Canada. 1979. Substances in the list of priority chemicals - 1979. Commercial Chemicals Branch, Ottawa, Ontario (CCB-IN-3-80).
Environment Canada. 1983. Hexachlorobutadiene. In: Guidelines for surface water quality. Volume 2. Organic chemical substances. Water Quality Branch, Inland Waters Directorate, Ottawa, Ontario.
Environment Canada. 1997a. Environmental assessments of Priority Substances under the Canadian Environmental Protection Act. Guidance manual version 1.0 - March 1997. Chemicals Evaluation Division, Commercial Chemicals Evaluation Branch, Ottawa, Ontario (EPS 2/CC/3E).
Environment Canada. 1997b. CEPA Section 16 Notice to Industry respecting the second Priority Substances List and di(2-ethylhexyl)phthalate. Use Patterns Section, Commercial Chemicals Evaluation Branch, Hull, Quebec.
Environment Canada. 1997c. Results of the CEPA Section 16 Notice to Industry respecting the second Priority Substances List and di(2-ethylhexyl)phthalate. Use Patterns Section, Commercial Chemicals Evaluation Branch, Hull, Quebec.
Environment Canada. 1999. Canadian Environmental Protection Act - Priority Substances List supporting document for the environmental assessment of hexachlorobutadiene. Commercial Chemicals Evaluation Branch, Hull, Quebec.
Environment Canada and Health Canada. 2000. Publication after assessment of a substance -hexachlorobutadiene - specified on the Priority Substances List (Subsection 77(1) of the Canadian Environmental Protection Act, 1999). Canada Gazette, Part I, July 1, 2000. pp. 2015-2018.
Environment Canada, United States Environmental Protection Agency, Ontario Ministry of the Environment and New York Department of Environmental Conservation. 1995. Joint evaluation of upstream/downstream Niagara River monitoring data for the period April 1993 to March 1994. Report prepared by the River Monitoring Committee, Niagara River Data Interpretation Group.
Environment Ontario. 1987. Ottawa (Lemieux Island) Water Treatment Plant. Annual report 1987.
Farara, D.G. and A.J. Burt. 1997. Assessment of Upper St. Clair River sediments and benthic macroinvertebrate communities - 1994. Report prepared by Beak Consultants Ltd. for the Ontario Ministry of Environment and Energy, Toronto, Ontario.
Fox, M.E., J.H. Carey and B.G. Oliver. 1983. Compartmental distribution of organochlorine contaminants in the Niagara River and the western basin of Lake Ontario. J. Great Lakes Res. 9: 287-294.
Fragiadakis, A., W. Klein, F. Korte, P.N. Moza, I. Scheunert, D. Vockel and U. Weiss. 1979. [Behaviour of organohalogen compounds in the plant-soil systems.] Spez. Ber. Kernforschungsanlage Juelich 45: 144-155 (in German).
Gage, J.C. 1970. The subacute inhalation toxicity of 109 individual chemicals. Br. J. Ind. Med. 27: 1-8.
Galloway, S.M., M.J. Armstrong, C. Reuben, S. Colman, B. Brown, C. Cannon, A.D. Bloom, F. Nakamura, M. Ahmed, S. Duk, J. Rimpo, B.H. Margolin, M.A. Resnick, B. Anderson and E. Zeiger. 1987. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: Evaluation of 108 chemicals. Environ. Mol. Mutagen. 10 (Suppl. 10): 1-175.
Geiger, D.L., C.E. Northcott, D.J. Call and L.T. Brooke. 1985. Acute toxicities of organic chemicals to fathead minnows (Pimephales promelas). Volume II. Center for Lake Superior Environmental Studies, University of Wisconsin-Superior, Superior, Wisconsin. pp. 51-52.
German, I.V. 1986. [Level of chromosome aberrations in workers coming in contact with hexachlorobutadiene during production.] Gig. Tr. Prof. Zabol. 5: 57-59 (in Russian).
German, I.V. 1988. Mutagenic activity of the pesticide hexachlorobutadiene. Tsitol. Genet. 22: 40-42.
Goldbach, R.W., H. Van Genderen and P. Leeuwangh. 1976. Hexachlorobutadiene residues in aquatic fauna from surface water fed by the river Rhine. Sci. Total Environ. 6: 31-40.
Govind, R., P.A. Flaherty and R.A. Dobbs. 1991. Fate and effects of semivolatile organic pollutants during anaerobic digestion of sludge. Water Res. 25: 547-556.
Gradiski, D., P. Duprat, J.L. Magadur and E. Fayein. 1975. Étude toxicologique expérimentale de l'hexachlorobutadiène. Eur. J. Toxicol. 8: 180-187.
Graham, H. 1993. Personal communication, letter dated September 17, 1993. Water Resources Branch, Ontario Ministry of the Environment.
Gulko, A.G., N.I. Zimina and I.G. Shroit. 1964. Toxicological study of the insecticide hexachlorobutadiene. Vopr. Gig. Sanit. Ozdorovl. Vneshn. Sredy, Kishinev. Sb. [abstracted in Chem. Abstr. 62: 13757c (1965)].
Hardin, B., G.P. Bond, M.R. Sikov, F.D. Andrew, R.P. Beliles and R.W. Niemeier. 1981. Testing of selected workplace chemicals for teratogenic potential. Scand. J. Work. Environ. Health 7 (Suppl. 4): 66-75.
Harleman, J.H. and W. Seinen. 1979. Short-term toxicity and reproduction studies in rats with hexachloro-(1,3)-butadiene. Toxicol. Appl. Pharmacol. 47: 1-14.
Haworth, S., T. Lawlor, K. Mortelmans, W. Speck and E. Zeiger. 1983. Salmonella mutagenicity test results for 250 chemicals. Environ. Mutagen. 5 (Suppl. 1): 3-142.
Health Canada. 1994. Human health risk assessment for Priority Substances. Canadian Environmental Protection Act. Ottawa, Ontario.
Henschler, D. and W. Dekant. 1990. Nephrocarcinogenic xenobiotics. Toxicol. Lett. 53: 105-110.
Howard, P. 1991. Handbook of environmental fate and exposure data for organic chemicals. Lewis Publishers, London, U.K. pp. 360-369.
Howard, P., R. Boethling, W. Jarvis, W. Meylan and E. Michalenko. 1991. Handbook of environmental degradation rates. H. Lewis Publishers, Boca Raton, Florida.
IARC (International Agency for Research on Cancer). 1979. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Volume 20. Hexachlorobutadiene. World Health Organization, Lyon, France.
IPCS (International Programme on Chemical Safety). 1994. Environmental Health Criteria 156 - Hexachlorobutadiene. World Health Organization, Geneva, Switzerland. Jaffe, D.R., C.D. Hassal and K. Brendel. 1983.
In vivo and in vitro nephrotoxicity of the cysteine conjugate of hexachlorobutadiene. J. Toxicol. Environ. Health 11: 857-867.
Jobb, B., R. Hunsinger, O. Meresz and V. Taguchi. 1993. Removal of N-nitrosodimethylamine from the Ohsweken (Six Nations) water supply. Interim report, July 1993. Ontario Ministry of Environment and Energy.
Johnson, L.D. and J.C. Young. 1983. Inhibition of anaerobic digestion by organic priority pollutants. J. Water Pollut. Control Fed. 55(12): 1441-1449.
Jonker, D., R.A. Woutersen, P.J. van Bladeren, H.P. Til and V.J. Feron. 1993. Subacute (4-wk) toxicity of a combination of four nephrotoxicants in rats: compared with the toxicity of the individual compounds. Food Chem. Toxicol. 31: 125-136.
Juhnke, I. and D. Lüdemann. 1978. Results of the study of 200 chemical compounds on acute fish toxicity using the golden orfe test. Z. Wasser Abwasser Forsch. 11(5): 161-164.
Kauss, P.B. 1996. Personal communication, December 20, 1996. Ontario Ministry of Environment and Energy, Etobicoke, Ontario.
Kauss, P.B. 1997. Personal communication, May 5, 1997. Ontario Ministry of Environment and Energy, Etobicoke, Ontario.
Kauss, P.B. and Y.S. Hamdy. 1985. Biological monitoring of organochlorine contaminants in the St. Clair and Detroit rivers using introduced clams (Elliptio complanatus). J. Great Lakes Res. 11(3): 247-263.
Kendall, P.R.W. 1990. The quality of drinking water in Toronto: A review of tap water, bottled water and water treated by point-of-use device. Environmental Protection Office, Department of Public Health, City of Toronto.
Knie, J., A. Haelke, I. Juhnke and W. Schiller. 1983. Results of studies of chemical substances using four biotests. Dtsch. Gewaesserkd. Mitt. 27(3): 77-79.
Kociba, R.J., P.G. Gehring, C.G. Humniston and G.L. Sparschu. 1971. Toxicologic study of female rats administered hexachlorobutadiene or hexachlorobenzene for thirty days. The Dow Chemical Company, Midland, Michigan [cited in Kociba et al., 1977b; IPCS, 1994].
Kociba, R.J., D.G. Keyes, G.C. Jersey, J.J. Ballard, D.A. Dittenber, J.F. Quast, C.E. Wade, C.G. Humiston and B.A. Schwetz. 1977a. Results of a two year chronic toxicity study with hexachlorobutadiene in rats. Am. Ind. Hyg. Assoc. J. 38: 589-602.
Kociba, R.J., B.A. Schwetz, D.G. Keyes, G.C. Jersey, J.J. Ballard, D.A. Dittenber, J.F. Quast, C.E. Wade and C.G. Humiston. 1977b. Chronic and reproduction studies of hexachlorobutadiene in rats. Environ. Health Perspect. 21: 49-53.
Kotzias, D., W. Klein and F. Korte. 1975. [Analysis of residues of hexachlorobutadiene in foodstuff and poultry.] Chemosphere 4: 247-250 (in German).
Kusz, P., A. Andriysiak and Z. Pokorska. 1984. Gas chromatographic monitoring of the chlorolysis processes of some byproducts from vinyl chloride, allyl chloride and epichlorohydrin production. J. Chromatogr. 286: 287-291.
Laseter, J.L., C.K. Bartell, A.L. Laska, D.G. Holmquist and D.B. Condie. 1976. Ecological study of hexachlorobutadiene (HCBD). U.S. Environmental Protection Agency, Washington, D.C. (EPA-68-01-2689).
Laska, A.L., C.K. Bartell, D.B. Condie, J.W. Brown, R.L. Evans and J.L. Laseter. 1978. Acute and chronic effects of hexachlorobenzene and hexachlorobutadiene in red swamp crayfish (Procambarus clarki) and selected fish species. Toxicol. Appl. Pharmacol. 43(1): 1-12.
Leeuwangh, P., H. Bult and L. Schneiders. 1975. Toxicity of hexachlorobutadiene in aquatic organisms. Sublethal effects of toxic chemicals on aquatic animals. Proceedings of the Swedish-Netherlands Symposium, September 2-5, 1975. Elsevier, Amsterdam, The Netherlands. 167 pp.
L'Italien, S. 1996. Organic contaminants in Lake Ontario in 1992 and 1993: Protocols and data report. Ecosystem Health Division, Environmental Conservation Branch, Ontario Region, Environment Canada, Burlington, Ontario (EHD/ECD/-OR/96-01/I).
Lock, E.A. 1994. The role of mechanistic studies in understanding target organ toxicity. Arch. Toxicol. Suppl. 16: 151-160.
Lock, E.A. and J. Ishmael. 1979. Original investigations: the acute toxic effects of hexachloro-1:3-butadiene on the rat kidney. Arch. Toxicol. 43: 47-57.
Lock, E.A., J. Ishmael and J.B. Hook. 1984. Nephrotoxicity of hexachloro-1,3-butadiene in the mouse: The effect of age, sex, strain, monooxygenase modifiers, and the role of glutathione. Toxicol. Appl. Pharmacol. 72: 484-494.
Malins, D.C., M.M. Krahn, M.S. Nyers, L.D. Rhoses, D.W. Brown, C.A. Krone, B.B. McCain and S.I. Chan. 1985. Toxic chemicals in sediments and biota from a creosote-polluted harbor: relationships with hepatic neoplasms and other hepatic lesions in English sole (Parophrys vetulus). Carcinogenesis 6: 1463-1469 [cited in IPCS, 1994].
Manahan, S. 1992. Fundamentals of environmental chemistry. Lewis Publishers, Boca Raton, Florida.
Mayer, F.L. and M.R. Ellersieck. 1986. Manual of acute toxicity: Interpretation and data base for 410 chemicals and 66 species of freshwater animals. U.S. Fish Wildl. Serv. Resour. Publ. 160: 1-226.
McCarthy, R., G.M. Hawksworth and E.A. Lock. 1992. Subcellular localisation of C-S lyase activity in human renal cortex. 13th European Workshop on Drug Metabolism, September 21-25, 1992, Bergamo, Italy [cited in Lock, 1994].
McConnell, G., D.M. Ferguson and C.R. Pearson. 1975. Chlorinated hydrocarbons in the environment. Endeavor 34: 13-18.
Meek, M.E., R. Newhook, R.G. Liteplo and V.C. Armstrong. 1994. Approach to assessment of risk to human health for Priority Substances under the Canadian Environmental Protection Ac t. Environ. Carcinogen. Ecotoxicol. Rev. C12(2): 105-134.
Mes, J., D. Davis, D. Turton and W.F. Sun. 1986. Levels and trends of chlorinated hydrocarbon contaminants in the breast milk of Canadian women. Food Addit. Contam. 3: 313-322.
Ministers'Expert Advisory Panel. 1995. Report of the Ministers'Expert Advisory Panel on the second Priority Substances List under the Canadian Environmental Protection Act (CEPA). Government of Canada, Ottawa, Ontario. 26 pp.
Munro, S. 2000. Personal communication, Communication dated August 21, 2000. Sarnia-Lambton Environmental Association.
Mudroch,A., R.J. Allan and S.R. Joshi. 1992. Geochemistry and organic contaminants in the sediments of Great Slave Lake, Northwest Territories, Canada. Arctic 45(1): 10-19.
Murzakaev, F.G. 1963. Toxicity data for hexachlorobutadiene and its intermediates. Farmakol. Toksikol. 26: 750 [abstracted in Chem. Abstr. 60: 13776b (1964)].
Nash, J.A., L.J. King, E.A. Lock and T. Green. 1984. The metabolism and disposition of hexachloro-1:3-butadiene in the rat and its relevance to nephrotoxicity. Toxicol. Appl. Pharmacol. 73: 124-137.
NIOSH (National Institute for Occupational Safety and Health). 1981. Tier II mutagenic screening of 13 NIOSH priority compounds: Individual compound report hexachloro-1,3-butadiene. Cincinnati, Ohio (PB83-152397).
NPRI (National Pollutant Release Inventory). 1994. Summary report 1994 National Pollutant Release Inventory. Prepared by M. Nobert, Environment Canada (Cat. No. EN40-495\1-1994E; ISBN 0-662-24996-8).
NTP (National Toxicology Program). 1990. Final report on the peri-/postnatal evaluation of hexachloro-1,3-butadiene (HCBD) toxicity in CD rats. Research Triangle Park, North Carolina.
NTP (National Toxicology Program). 1991. Toxicity studies of hexachloro-1,3-butadiene in B6C3F1 mice (feed studies). Research Triangle Park, North Carolina (NTP TOX 1; NIH Publication No. 91-3120).
Oliver, B.G. and K.L.E. Kaiser. 1986. Chlorinated organics in nearshore waters and tributaries of the St. Clair River. Water Pollut. Res. J. Can. 21(3): 344-350.
Oliver, B.G. and K.D. Nicol. 1982. Gas chromatographic determination of chlorobenzenes and other chlorinated hydrocarbons in environmental samples using fused silica capillary columns. Chromatographia 16: 336-340.
Oliver, B.G. and A.J. Niimi. 1983. Bioconcentration of chlorobenzenes from water by rainbow trout: correlations with partition coefficients and environmental residues. Environ. Sci. Technol. 17(5): 287-291.
Oliver, B.G. and C.W. Pugsley. 1986. Chlorinated contaminants in St. Clair River sediments. Water Pollut. Res. J. Can. 21(3): 368-379.
OME (Ontario Ministry of the Environment). 1991. St. Clair River MISA pilot site investigation. Volume II, Part II - Detailed technical findings. Municipal/Industrial Strategy for Abatement (MISA).
OME (Ontario Ministry of the Environment). 1992. Twelve-month monitoring data report - Organic Chemical Manufacturing Sector (Period covered: October 1, 1989 to July 31, 1991). Prepared by T.M. Tuszynski, Municipal/Industrial Strategy for Abatement (MISA) Section, Water Resources Branch, Ontario Ministry of the Environment, September 1992 (PIBS 2112, Log 92-2310046).
OMEE (Ontario Ministry of Environment and Energy). 1996. Unpublished data from the Ontario Drinking Water Surveillance Program, provided by John McGrachan, Environmental Monitoring and Reporting Branch, Etobicoke, Ontario, May 2, 1996.
OME/MDNR (Ontario Ministry of the Environment/Michigan Department of Natural Resources). 1991. The St. Clair River Area of Concern. Environmental conditions and problem definitions: Remedial Action Plan Stage I. Submission to the International Joint Commission, December 20, 1991.
Pearson, C.R. and G. McConnell. 1975. Chlorinated C1 and C2 hydrocarbons in the marine environment. Proc. R. Soc. London 189(B): 305-332.
Reichert, D., T. Neudecker, U. Spengler and D. Henschler. 1983. Mutagenicity of dichloroacetylene and its degradation products trichloroacetyl chloride, trichloroacyloyl chloride and hexachlorobutadiene. Mutat. Res. 117: 21-29.
Reichert, D., T. Neudecker and S. Schutz. 1984. Mutagenicity of hexachlorobutadiene, perchlorobutenoic acid and perchlorobutenoic acid chloride. Mutat. Res. 137: 89-93.
Riopel, A. 1996. Personal communication, letter dated April 16, 1996. Unpublished data, Gouvernement du Québec, Ministère de l'Environnement et de la Faune, Direction des politiques du secteur municipal, Service de l'assainissement des eaux et du traitement des eaux de consommation.
Roederer, G., F. Brüggemann, H. Schäfer, K. Schöne, A. König and J. Steinhanses. 1989. Testung wassergefährdener stoffe als grundlage für wasser-qualitätsstandards. Testbericht, Fraunhofer-Institut für Umweltchemie und Ökotoxikologie, Schmallenberg, Switzerland. pp. 8-20.
Roldán-Arjona, T., M.D. García-Pedrajas, F.L. Luque-Romero, C. Hera and C. Pueyo. 1991. An association between mutagenicity of the Ara test of Salmonella typhimurium and carcinogenicity in rodents for 16 halogenated aliphatic hydrocarbons. Mutagenesis 6(3): 199-205.
Saillenfait, A.M., P. Bonnet, J.P. Guenier and J. de Ceaurriz. 1989. Inhalation teratology study on hexachloro-1,3-butadiene in rats. Toxicol. Lett. 47: 235-240.
Sarnia-Lambton Environmental Association. 2000. 1999 Annual Progress Report. Lambton Inudustrial Society. 16 pp.
Schrenk, D. and W. Dekant. 1989. Covalent binding of hexachlorobutadiene metabolites to renal and hepatic mitochondrial DNA. Carcinogenesis 10: 1139-1141.
Schwetz, B.A., F.A. Smith and C.G. Humiston. 1977. Results of a reproduction study in rats fed diets containing hexachlorobutadiene. Toxicol. Appl. Pharmacol. 42: 387-398.
Shen, T.T. 1982. Air quality assessment for land disposal of industrial wastes. Environ. Manage. 6: 297-305.
SIDS Manual. 1994. Screening Information Data Set (SIDS) Manual of the OECD Programme on the Co-operative Investigation of High Production Volume (HPV) Chemicals (MANUAL\9405.DOC/July 1994).
Slooff, W. 1979. Detection limits of a biological monitoring system based on fish respiration. Bull. Environ. Contam. Toxicol. 23(4-5): 517-523.
Stott, W.T., J.F. Quast and P.G. Watanabe. 1981. Differentiation of the mechanism of oncogenicity of 1,4-dioxane and 1,3-hexachlorobutadiene in the rat. Toxicol. Appl. Pharmacol. 60: 287-300.
Tabak, H.H., S.A. Quave, C.I. Mashni and E.F. Barth. 1981. Biodegradability studies with organic priority pollutant compounds. J. Water Pollut. Control Fed. 53(10): 1503-1518.
Theiss, J.C., G.D. Stoner, M.B. Shimkin and E.K. Weisburger. 1977. Test for carcinogenicity of organic contaminants of United States waters by pulmonary tumor response in strain A mice. Cancer Res. 37: 2717-2720.
Toxic Release Inventory. 1997. Toxic Chemical Release Inventory. National Toxicology Information Program, National Library of Medicine, Bethesda, Maryland.
U.S. EPA (United States Environmental Protection Agency). 1980. Ambient water quality criteria for hexachlorobutadiene (HCBD). Criteria and Standards Division, Washington, D.C. (EPA 440/5-80-053).
Vamvakas, S., F.J. Kordowich, W. Dekant, T. Neudecker and D. Henschler. 1988. Mutagenicity of hexachloro-1,3-butadiene and its S-conjugates in the Ames test - role of activation by the mercapturic acid pathway and its nephrocarcinogenicity. Carcinogenesis 9: 907-916.
Van Duuren, B.L., B.M. Goldschmid, G. Loewengart, A.C. Smith, S. Melchionne, I. Seldman and D. Roth. 1979. Carcinogenicity of halogenated olefinic and aliphatic hydrocarbons in mice. J. Natl. Cancer Inst. 63: 1433-1439.
Walbridge, C.T., J.T. Fiandt, G.L. Phipps and G.W. Holcombe. 1983. Acute toxicity of ten chlorinated aliphatic hydrocarbons to the fathead minnow (Pimephales promelas). Arch. Environ. Contam. Toxicol. 12(6): 661-666.
Webber, M.D. and C. Wang. 1995. Industrial organic compounds in selected Canadian soils. Can. J. Soil Sci. 75(4): 513-524.
Wild, D., S. Schutz and D. Reichert. 1986. Mutagenicity of the mercapturic acid and other S-containing derivatives of hexachloro-1,3-butadiene. Carcinogenesis 7: 431-434.
Yang, R.S.H. 1988. Hexachloro-1,3-butadiene: toxicology, metabolism, and mechanisms of toxicity. Rev. Environ. Contam. Toxicol. 101: 121-137.
Yang, R.S., K.M. Abdo and M.R. Elwell. 1989. Subchronic toxicity studies of hexachloro-1,3- butadiene (HCBD) in B6C3F 1 mice by dietary incorporation. J. Environ. Pathol. Toxicol. Oncol. 9: 323-332.
Yip, G. 1976. Survey of hexachloro-1,3-butadiene in fish, eggs, milk and vegetables. J. Assoc. Off. Anal. Chem. 59: 559-561.
Zanette, M. 1996. Personal commu nica tion. Unpublished data provided July 16, 1996, by Greater Victoria Water District.
Zhu, J. 1997. Hexachlorobutadiene levels in samples collected during multimedia exposure pilot study. Memo to R. Beauchamp, Priority Substances Section, Environmental Health Directorate, Health Canada, dated April 10, 1997.