Guidance on Chloral Hydrate in Drinking Water

Part B - Supporting information

B.4 References and acronyms

B.4.1 References

• Abbas, R.R., Seckel, C.S., Kidney, J.K. and Fisher, J.W. (1996) Pharmacokinetic analysis of chloral hydrate and its metabolism in B6C3F1 mice. Drug Metab. Dispos., 24(12): 1340-1346.
• Allen, B.C. and Fisher, J.W. (1993) Pharmacokinetic modeling of trichloroethylene and trichloroacetic acid in humans. Risk Anal., 13: 71-86.
• Allen, J.W., Collins, B.W. and Evansky, P.A. (1994) Spermatid micronucleus analyses of trichloroethylene and chloral hydrate effects in mice. Mutat. Res., 323(1-2): 81-88.
• APHA (American Public Health Association), AWWA (American Water Works Association) and WEF (Water Environment Federation) (2005) Standard methods for the examination of water and wastewater. 21st edition. Washington, DC. p. 5.70.
• Beland, F.A. (1999) NTP technical report on the toxicity and metabolism studies of chloral hydrate (CAS No. 302-17-0) administered by gavage to F344/N rats and B6C3F1 mice. National Toxicology Program, National Institutes of Health, Research Triangle Park, NC. pp. 1-136 (NTP Toxicity Report Series No. 59).
• Beland, F.A., Schmitt, T.C., Fullerton, N.F. and Young, J.F. (1998) Metabolism of chloral hydrate in mice and rats after single and multiple doses. J. Toxicol. Environ. Health, 54: 209-226.
• Benoit, F.M., LeBel, G.L. and Jay, B. (2000) Evaluation of remedial actions to reduce the levels of chlorinated disinfection by-products in drinking water at the point of use. Proceedings of the 9th National Conference on Drinking Water, Regina, Saskatchewan, May 16-18, 2000.
• Bignami, M., Conti, G., Conti, L., Crebelli, R., Misuraca, F., Puglia, A.M., Randazzo, R., Sciandrello, G. and Carere, A. (1980) Mutagenicity of halogenated aliphatic hydrocarbons in Salmonella typhimurium, Streptomyces coelicolor and Aspergillus nidulans. Chem. Biol. Interact., 30: 9-23.
• Bruce, W.R. and Heddle, J.A. (1979) The mutagenic activity of 61 agents as determined by the micronucleus, Salmonella, and sperm abnormality assays. Can. J. Gen. Cytol., 21: 319-334.
• Budavari, S. (1996) The Merck index. An encyclopedia of chemicals, drugs, and biologicals. 12th edition. Merck and Co. Inc., Whitehouse Station, NJ.
• Butler, T.C. (1948) The metabolic fate of chloral hydrate. J. Pharmacol. Exp. Ther., 92: 49-58.
• Chang, L.W., Daniel, F.B. and DeAngelo, A.B. (1992) Analysis of DNA strand breaks induced in rodent liver in vivo, hepatocytes in primary culture, and a human cell line by chlorinated acetic acid and chlorinated acetaldehydes. Environ. Mol. Mutagen., 20(4): 277-288.
• Daniel, F.B., DeAngelo, A.B., Stober, J.A., Olson, G.R. and Page, N.P. (1992a) Hepatocarcinogenicity of chloral hydrate, 2-chloroacetaldehyde, and dichloroacetic acid in the male B6C3F1 mouse. Fundam. Appl. Toxicol., 19(2): 159-168.
• Daniel, F.B., Robinson, M., Stober, J.A., Page, N.P. and Olson, G.R. (1992b) Ninety-day toxicity study of chloral hydrate in the Sprague-Dawley rat. Drug Chem. Toxicol., 15: 217-232.
• Edsall, T.A. and Charlton, M.N. (1997) Nearshore waters of the Great Lakes. State of the Lakes Ecosystem Conference 1996. U.S. Environmental Protection Agency and Environment Canada (EPA 905-R-97-015A; Catalogue No. En40-11/35-1-1-1997E).
• Ellenhorn, M.J. and Barceloux, D.G. (1988) Medical toxicology. Diagnosis and treatment of human poisoning. Elsevier Science Publishing Co., Inc., New York, NY.
• Ellenhorn, M.J., Schonwald, S., Ordog, G. and Wasserberger, J. (1997) Ellenhorn's medical toxicology: Diagnosis and treatment of human poisoning. 2nd edition. Williams and Wilkins, Baltimore, MD.
• George, M., Moore, T., Kilburn, S., Olson, G.R. and DeAngelo, A.B. (2000) Carcinogenicity of chloral hydrate administered in drinking water to the male F344/N rat and male B6C3F1 mouse. Toxicol. Pathol., 28: 610-618.
• Gilman, A.G., Goodman, L.S. and Gilman, A. (1985) Chloral hydrate. In: Goodman and Gilman's the pharmacological basis of therapeutics. Macmillan, New York, NY. pp. 352, 370.
• Greenberg, S.B., Faerber, E.N. and Aspinall, C.L. (1991) High-dose chloral hydrate sedation for children undergoing CT. J. Comput. Assist. Tomogr., 15: 467-469.
• Gu, Z.W., Sele, B., Jalbert, P., Vincent, M., Vincent, F., Marka, C., Chmara, D. and Faure, J. (1981) [Induction of sister chromatid exchange by trichloroethylene and its metabolites.] Toxicol. Eur. Res., 3(2): 63-67 (in French).
• Hansch, C., Leo, A. and Hoekman, D. (1995) Exploring QSAR -- Hydrophobic, electronic, and steric constants. American Chemical Society, Washington, DC.
• Harrington-Brock, K., Doerr, C.L. and Moore, M.M. (1998) Mutagenicity of three disinfection by-products: di- and trichloroacetic acid and chloral hydrate in L5178Y/TK +/!(!)3.7.2C mouse lymphoma cells. Mutat. Res., 413(3): 265-276.
• Haseman, J.K., Hailey, J.R. and Morris, R.W. (1998) Spontaneous neoplasm incidences in Fischer 344 rats and B6C3F1 mice in two-year carcinogenicity studies: A National Toxicology Program update. Toxicol. Pathol., 26(3): 428-441.
• Health Canada (1994) Canadian Environmental Protection Act. Human health risk assessment for priority substances. Minister of Supply and Services Canada, Ottawa, Ontario (Catalogue No. En40-215/41E).
• Health Canada (1995) A national survey of chlorinated disinfection by-products in Canadian water. Environmental Health Directorate, Health Canada, Ottawa, Ontario (95-EHD-197).
• Henderson, G.N., Yan, Z., James, M.O., Davydova, N. and Stacpoole, P.W. (1997) Kinetics and metabolism of chloral hydrate in children: identification of dichloroacetate as a metabolite. Biochem. Biophys. Res. Commun., 235: 695-698.
• IARC (International Agency for Research on Cancer) (1995) Chloral and chloral hydrate. IARC Monogr. Eval. Carcinogen. Risks Hum., 63: 245-269.
• IPCS (International Programme on Chemical Safety) (2000) Chloral hydrate. World Health Organization, Geneva (Concise International Chemical Assessment Document No. 25).
• Johnson, P.D., Dawson, B.V. and Goldberg, S.J. (1998) Cardiac teratogenicity of trichloroethylene metabolites. J. Am. Coll. Cardiol., 32: 540-545.
• Kallman, M.J., Kaempf, G.L. and Balster, R.L. (1984) Behavioral toxicity of chloral in mice: an approach to evaluation. Neurobehav. Toxicol. Teratol., 6: 137-146.
• Kauffmann, B.M., White, K.L., Sanders, V.M., Douglas, K.A., Sain, L.E., Borzelleca, J.F. and Munson, A.E. (1982) Humoral and cell-mediated status in mice exposed to chloral hydrate. Environ. Health Perspect., 44: 147-151.
• Ketcha, M.M., Stevens, D.K., Warren, D.A., Bishop, C.T. and Brashear, W.T. (1996) Conversion of trichloroacetic acid to dichloroacetic acid in biological samples. J. Anal. Toxicol., 20: 236-241.
• Kirk-Othmer (1991) Kirk-Othmer encyclopedia of chemical technology. 4th edition. Wiley Interscience, New York, NY.
• Klinefelter, G.R., Suarez, J.D., Roberts, N.L. and DeAngelo, A.B. (1995) Preliminary screening for the potential of drinking water disinfection by-products to alter male reproduction. Reprod. Toxicol., 9: 571-578.
• Krasner, S.W., McGuire, M.J., Jacangelo, J.G., Patania, N.L., Reagan, K.M. and Aieta, E.M. (1989) The occurrence of disinfection by-products in US drinking water. J. Am. Water Works Assoc., 81(8): 41-52.
• LeBel, G.L., Jay, B. and Benoit, F.M. (2002) Evaluation of filtration devices to reduce levels of chlorinated disinfection by-products (CDBPs) in drinking water at the point of use. Proceedings of the 10th National Conference on Drinking Water, Halifax, Nova Scotia, April 27-30, 2002.
• Leuschner, J. and Beuscher, N. (1998) Studies on the mutagenic and carcinogenic potential of chloral hydrate. Arzneimittel-Forschung, 48: 961-968.
• Lipscomb, J.C., Mahle, D.A., Brashear, W.T. and Garrett, C.M. (1996) A species comparison of chloral hydrate metabolism in blood and liver. Biochem. Biophys. Res. Commun., 227: 340-350.
• Mailhes, J.B., Aardena, M.J. and Marchetti, F. (1993) Investigation of aneuploidy induction in mouse oocytes following exposure to vintablastine-sulfate, pyrimethamine, diethylstibestrol diphosphate, or chloral hydrate. Environ. Mol. Mutagen., 22: 107-114.
• Marshall, E.K. and Owens, A.H. (1954) Absorption, excretion and metabolic fate of chloral hydrate and trichloroethanol. Bull. Johns Hopkins Hosp., 95: 1-18.
• McEvoy, G.K. (1999) American Hospital Formulary Service Drug Information 99. American Society of Health-System Pharmacists, Inc., Bethesda, MD.
• Merdink, J.L., Stenner, R.D., Stevens, D.K., Parker, J.C. and Bull, R.J. (1999) Effect of enterohepatic circulation on the pharmacokinetics of chloral hydrate and its metabolites in F344 rats. J. Toxicol. Environ. Health, 57: 357-368.
• Moore, M.M. and Harrington-Brock, K. (2000) Mutagenicity of trichloroethylene and its metabolites: implications for the risk assessment of trichloroethylene. Environ. Health Perspect., 108: 215-223.
• Natarajan, A.T., Duivenvooden, W.C., Meijers, M. and Zwanenburg, T.S. (1993) Induction of mitotic aneuploidy using Chinese hamster primary embryonic cells: Test results of 10 chemicals. Mutat. Res., 287(1): 47-56.
• Newman, L.M. and Wackett, L.P. (1991) Fate of 2,2,2-trichloroacetaldehyde (chloral hydrate) produced during trichloroethylene oxidation by methanotrophs. Appl. Environ. Microbiol., 57: 2399-2402.
• Ni, Y.C., Wong, T.Y., Lloyd, R.V., Heinze, T.M., Shelton, S., Casciano, D., Kadlubar, F.F. and Fu, P.P. (1996) Mouse liver microsomal metabolism of chloral hydrate, trichloroacetic acid, and trichloroethanol leading to induction of lipid peroxidation via a free radical mechanism. Drug Metab. Dispos., 24(1): 81-90.
• NTP (National Toxicology Program) (2002a) Toxicology and carcinogenesis studies of chloral hydrate in B6C3F1 mice (gavage studies). National Institutes of Health, Research Triangle Park, NC. 197 pp. (NTP Technical Report Series 502).
• NTP (National Toxicology Program) (2002b) Toxicology and carcinogenesis studies of chloral hydrate (ad libitum and dietary controlled) in male B6C3F1 mice (gavage study). National Institutes of Health, Research Triangle Park, NC. 218 pp. (NTP Technical Report Series 503).
• Odum, J., Foster, J.-R. and Green, T. (1992) A mechanism for the development of Clara cell lesions in the mouse lung after exposure to trichloroethylene. Chem.-Biol. Interact., 83(2): 135-153.
• Ogino, K., Hobara, T., Kobayashi, H. and Iwamoto, S. (1990) Gastric mucosal injury by chloral hydrate. Toxicol. Lett., 52(2): 129-133.
• Poon, R., Nadeau, B. and Chu, I. (2000) Biochemical effects of chloral hydrate on male rats following 7-day drinking water exposure. J. Appl. Toxicol., 20: 455-461.
• Poon, R., Nakai, J., Yagminas, A., Benoit, F., Moir, D., Chu, I. and Valli, V.E. (2002) Subchronic toxicity of chloral hydrate on rats -- a drinking water study. J. Appl. Toxicol., 22: 227-236.
• Reid Crowther & Partners Ltd. (2000) Canadian water treatment study: water treatment and disinfection byproducts. Edmonton, Alberta. September.
• Reynolds, J.E.F. and Prasad, A.B. (1982) Martindale -- The extra pharmacopia. 28th edition. The Pharmaceutical Press, London.
• Rijhsinghani, K.S., Abrahams, C., Swerdlow, M.A., Rao, K.V.N. and Ghose, T. (1986) Induction of neoplastic lesions in the livers of C57BL × C3HF1 mice by chloral hydrate. Cancer Detect. Prev., 9(3-4): 279-288.
• Saillenfait, A.M., Langonne, I. and Sabate, J.P. (1995) Developmental toxicity of trichloroethylene, tetrachloroethylene and four of their metabolites in rat whole embryo cultures. Arch. Toxicol., 70: 71-78.
• Sanders, V.M., Kauffman, B.M., White, K.L., Douglas, K.A., Barnes, D.W., Sain, L.E., Bradshaw, T.J., Borzelleca, J.F. and Munson, A.E. (1982) Toxicology of chloral hydrate in the mouse. Environ. Health Perspect., 44: 137-146.
• Sbrana, I., Di Sibio, A., Lomi, A. and Scarcelli, V. (1993) C-mitosis and numerical chromosome aberration analyses in human lymphocytes: 10 known or suspected spindle poisons. Mutat. Res., 287(1): 57-70.
• Shapiro, S., Stone, D., Lewis, G.P. and Jick, H. (1969) Clinical effects of hypnotics. II. An epidemiological study. J. Am. Med. Assoc., 209: 2016-2020.
• Stenner, R.D., Merdink, J.L., Fisher, J.W. and Bull, R.J. (1998) Physiologically-based pharmacokinetic model for trichloroethylene considering enterohepatic recirculation of major metabolites. Risk Anal., 18(3): 261-269.
• U.S. EPA (United States Environmental Protection Agency) (1992) Technical Support Division Disinfection By-Products Field Study Database. Technical Support Division, Office of Ground Water and Drinking Water, U.S. EPA, Cincinnati, OH.
• U.S. EPA (United States Environmental Protection Agency) (1995) Methods for the determination of organic compounds in drinking water -- Supplement III. U.S. EPA, Washington, DC (EPA-600/R-95/131).
• U.S. EPA (United States Environmental Protection Agency) (1998a) National Primary Drinking Water Regulations; disinfectants and disinfection byproducts: Notice of data availability. 40 CFR Parts 141 and 142. Fed. Regist., 63(145): 15674-15692.
• U.S. EPA (United States Environmental Protection Agency) (1998b) National Primary Drinking Water Regulations: disinfectants and disinfection byproducts. 40 CFR Parts 9, 141, and 142. Fed. Regist., 63: 6904.
• U.S. EPA (United States Environmental Protection Agency) (1999) EPA guidance manual -- Alternative disinfectants and oxidants. U.S. EPA, Washington, DC, April (EPA-815-R-99-014).
• U.S. EPA (United States Environmental Protection Agency) (2000) Toxicological review of chloral hydrate. In support of summary information on the Integrated Risk Information System (IRIS). U.S. EPA, Washington, DC (EPA/635/R-00/006).
• Verschueren, K. (2001) Handbook of environmental data on organic chemicals. 3rd edition. Van Nostrand Reinhold Co., New York, NY.
• Warr, T.J., Parry, E.M. and Parry, J.M. (1993) A comparison of two in vivo mammalian cell cytogenetic assays for the detection of mitotic aneuploidy using 10 known or suspect aneugens. Mutat. Res., 287(1): 29-46.
• Waskell, L. (1978) A study of the mutagenicity of anesthetics and their metabolites. Mutat. Res., 57(2): 141-153.
• Williams, D.T., LeBel, G.L. and Benoit, F.M. (1997) Disinfection by-products in Canadian drinking water. Chemo-sphere, 34: 299-316.
• Xie, Y.F. (2004) Disinfection byproducts in drinking water: Formation, analysis, and control. Lewis Publishers, CRC Press, Boca Raton, FL.
• Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C. and Zimmering, S. (1985) Chemical mutagenesis testing in Drosophila. IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen., 7: 349-367.
• Zimmermann, T., Wehling, M. and Schulz, H.U. (1998) [The relative bioavailability and pharmacokinetics of chloral hydrate and its metabolites.] Arzneimittelforschung, 48: 5-12 (in German).