Health Canada
Symbol of the Government of Canada
Health Concerns

Aromatic Amines: Contribution to the Mutagenic Activity of Tobacco Smoke

The content on this page exceeds normal site dimensions due to the use of a larger table.

Table 1: Substance concentration in mainstream tobacco smoke and capacity to induce mutations
Chemical Substance concentration
(ng/cig)
Capacity to induce mutations TA98
(mutations/ng)
Capacity to induce mutations TA1537
(mutations/ng)
Capacity to induce mutations TA100
(mutations/ng)
Contribution to mutagenic activity TA98
(mutations/cig)
Contribution to mutagenic activity TA1537
(mutations/cig)
Contribution to mutagenic activity TA100
(mutations/cig)
Norharman 5,659 3 - - 16,977 - -
Harman  1,823 14 1 - 25,522 1,823 -
AαC 131 112 14 16 14,672 1,834 2,096
o-toluidine  104 197 27  -  20,488 2,808 -
1-aminonaphthalene 19 1,030 126 140 19,570 2,394 2,660
MeAαC 14 1,488 177 210 20,832 2,478 2,940
2-aminonaphthalene  12 1,475 183 194 17,700 2,196 2,328
o-anisidine 4 4,469 568 - 17,876 2,272 -
3-aminobiphenyl  3 6,021 778 861 18,063 2,334 2,583
4-aminobiphenyl 2 7,531 996 923 15,062 1,992 1,846

Back